Showing entry for Fibrinogen alpha chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005914
Protein NameFibrinogen alpha chain
Uniport IdP02671
GeneFGA
Gene Id2243
DomainFibrinogen_aC; Fibrinogen_C; Fib_alpha
Pfam PF08702   PF12160   PF00147  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0007596 blood coagulation
Biological Process GO:0072377 blood coagulation, common pathway
Biological Process GO:0072378 blood coagulation, fibrin clot formation
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0034622 cellular protein-containing complex assembly
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0042730 fibrinolysis
Biological Process GO:0043152 induction of bacterial agglutination
Biological Process GO:0045087 innate immune response
Biological Process GO:2000261 negative regulation of blood coagulation, common pathway
Biological Process GO:2000352 negative regulation of endothelial cell apoptotic process
Biological Process GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:0031639 plasminogen activation
Biological Process GO:0070527 platelet aggregation
Biological Process GO:0002576 platelet degranulation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0045921 positive regulation of exocytosis
Biological Process GO:0034116 positive regulation of heterotypic cell-cell adhesion
Biological Process GO:0090277 positive regulation of peptide hormone secretion
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0045907 positive regulation of vasoconstriction
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0051258 protein polymerization
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0002224 toll-like receptor signaling pathway
molecular function GO:0005201 extracellular matrix structural constituent
molecular function GO:0046872 metal ion binding
molecular function GO:0005102 signaling receptor binding
molecular function GO:0005198 structural molecule activity
cellular component GO:0072562 blood microparticle
cellular component GO:0005938 cell cortex
cellular component GO:0009986 cell surface
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:1903561 extracellular vesicle
cellular component GO:0005577 fibrinogen complex
cellular component GO:0005886 plasma membrane
cellular component GO:0031091 platelet alpha granule
cellular component GO:0031093 platelet alpha granule lumen
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114608 Platelet degranulation
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade)
R-HSA-1474244 Extracellular matrix organization
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-216083 Integrin cell surface interactions
R-HSA-354192 Integrin signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-392499 Metabolism of proteins
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-597592 Post-translational protein modification
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-9607240 FLT3 Signaling
R-HSA-9649948 Signaling downstream of RAS mutants
R-HSA-9656223 Signaling by RAF1 mutants
R-HSA-977225 Amyloid fiber formation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000786 BXGD000010 Spontaneous abortion Female Urogenital Diseases and Pregnancy Complications
C0001733 BXGD000073 Afibrinogenemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0001787 BXGD000076 Osteoporosis, Age-Related Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012739 BXGD000786 Disseminated Intravascular Coagulation Hemic and Lymphatic Diseases
C0013221 BXGD000804 Drug toxicity Chemically-Induced Disorders
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0015499 BXGD000997 Hereditary Factor V Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0017181 BXGD001103 Gastrointestinal Hemorrhage Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0017565 BXGD001118 Gingival Hemorrhage Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0020625 BXGD001451 Hyponatremia Nutritional and Metabolic Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026640 BXGD001912 Mouth Neoplasms Neoplasms; Stomatognathic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029459 BXGD002159 Osteoporosis, Senile Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029607 BXGD002168 Other emphysema Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0032326 BXGD002351 Pneumothorax Respiratory Tract Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0034065 BXGD002454 Pulmonary Embolism Respiratory Tract Diseases; Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0041755 BXGD002933 Adverse reaction to drug Chemically-Induced Disorders
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042487 BXGD002986 Venous Thrombosis Cardiovascular Diseases
C0085278 BXGD003150 Antiphospholipid Syndrome Immune System Diseases
C0087086 BXGD003320 Thrombus Cardiovascular Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152031 BXGD003524 Joint swelling Pathological Conditions, Signs and Symptoms
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0155502 BXGD003796 Benign Paroxysmal Positional Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0232943 BXGD004570 Intermenstrual heavy bleeding Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242488 BXGD005170 Acute Lung Injury Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0268380 BXGD005921 Systemic amyloidosis Nutritional and Metabolic Diseases
C0268381 BXGD005922 Primary amyloidosis Neoplasms; Nutritional and Metabolic Diseases; Immune System Diseases
C0268382 BXGD005923 Amyloid nephropathy Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0268389 BXGD005928 Amyloidosis, familial visceral Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0272350 BXGD006354 Dysfibrinogenemia, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0281479 BXGD006776 Primary Systemic Amyloidosis Neoplasms; Nutritional and Metabolic Diseases; Immune System Diseases
C0337428 BXGD007155 Fibrinogen assay
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0398623 BXGD008202 Thrombophilia Hemic and Lymphatic Diseases
C0472803 BXGD008925 Hypodysfibrinogenemia
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0524702 BXGD009242 Pulmonary Thromboembolisms Respiratory Tract Diseases; Cardiovascular Diseases
C0553681 BXGD009406 Hypofibrinogenemia
C0585362 BXGD009592 Squamous cell carcinoma of mouth Digestive System Diseases; Neoplasms; Stomatognathic Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740340 BXGD009978 Amyloidosis, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751406 BXGD010428 Post-Traumatic Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C0857501 BXGD011152 Acute schizophrenia
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1260903 BXGD011842 Dysfibrinogenemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1325327 BXGD012455 fibrinogen activity
C1458140 BXGD013134 Bleeding tendency Hemic and Lymphatic Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1561955 BXGD013367 Fibrinogen, CTCAE
C1859970 BXGD015944 Hypodysfibrinogenemia, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1862968 BXGD016146 Generalized amyloid deposition Nutritional and Metabolic Diseases
C2584774 BXGD017130 Congenital hypofibrinogenemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2937358 BXGD018159 Cerebral Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C3463916 BXGD018901 Complement Factor I (C3 inactivator) deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4016070 BXGD020269 Fibrinogen dusart phenotype
C4081731 BXGD022080 Hereditary systemic amyloidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4316812 BXGD022704 Fibrinogen Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002682 Zinc 65.41
BXGC0004275 Acetaldehyde 44.05
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein