Showing entry for Peptidyl-prolyl cis-trans isomerase FKBP4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012672
Protein NamePeptidyl-prolyl cis-trans isomerase FKBP4
Uniport IdQ02790
GeneFKBP4
Gene Id2288
DomainFKBP_C; TPR_1
Pfam PF00254   PF00515   PF07719  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030521 androgen receptor signaling pathway
Biological Process GO:0061077 chaperone-mediated protein folding
Biological Process GO:0006825 copper ion transport
Biological Process GO:0007566 embryo implantation
Biological Process GO:0046661 male sex differentiation
Biological Process GO:0031115 negative regulation of microtubule polymerization
Biological Process GO:0031111 negative regulation of microtubule polymerization or depolymerization
Biological Process GO:0010977 negative regulation of neuron projection development
Biological Process GO:0030850 prostate gland development
Biological Process GO:0031503 protein-containing complex localization
Biological Process GO:0006457 protein folding
Biological Process GO:0000413 protein peptidyl-prolyl isomerization
Biological Process GO:1900034 regulation of cellular response to heat
Biological Process GO:0006463 steroid hormone receptor complex assembly
molecular function GO:0005524 ATP binding
molecular function GO:0032767 copper-dependent protein binding
molecular function GO:0005528 FK506 binding
molecular function GO:0035259 glucocorticoid receptor binding
molecular function GO:0005525 GTP binding
molecular function GO:0031072 heat shock protein binding
molecular function GO:0003755 peptidyl-prolyl cis-trans isomerase activity
molecular function GO:0051219 phosphoprotein binding
molecular function GO:0030674 protein-macromolecule adaptor activity
molecular function GO:0003723 RNA binding
molecular function GO:0048156 tau protein binding
cellular component GO:0044295 axonal growth cone
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005874 microtubule
cellular component GO:0005739 mitochondrion
cellular component GO:0043025 neuronal cell body
cellular component GO:0005654 nucleoplasm
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-2262752 Cellular responses to stress
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-3371556 Cellular response to heat stress
R-HSA-3371568 Attenuation phase
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-5663205 Infectious disease
R-HSA-8939211 ESR-mediated signaling
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000833 BXGD000014 Abscess Pathological Conditions, Signs and Symptoms; Infections
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001815 BXGD000078 Primary Myelofibrosis Hemic and Lymphatic Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013364 BXGD000819 Dysautonomia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0016529 BXGD001068 Forced expiratory volume function
C0017152 BXGD001096 Gastritis Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019340 BXGD001321 Herpes NOS Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024530 BXGD001783 Malaria Infections
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026948 BXGD001952 Mycosis Fungoides Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028840 BXGD002089 Ocular Hypertension Eye Diseases
C0029001 BXGD002104 Onchocerciasis Infections; Skin and Connective Tissue Diseases
C0029401 BXGD002135 Osteitis Deformans Musculoskeletal Diseases
C0029454 BXGD002155 Osteopetrosis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036631 BXGD002626 Seminoma Neoplasms
C0038354 BXGD002746 Stomach Diseases Digestive System Diseases
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0039585 BXGD002821 Androgen-Insensitivity Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042834 BXGD003004 Vital capacity
C0042870 BXGD003008 Vitamin D Deficiency Nutritional and Metabolic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079773 BXGD003100 Lymphoma, T-Cell, Cutaneous Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079774 BXGD003101 Peripheral T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0151514 BXGD003429 Atrophic condition of skin Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205682 BXGD004105 Waist-Hip Ratio
C0206180 BXGD004170 Ki-1+ Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0206650 BXGD004214 Fibroadenoma Neoplasms
C0220597 BXGD004292 Adult Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0220644 BXGD004306 Childhood Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0235889 BXGD004784 Arthritis aggravated Musculoskeletal Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238421 BXGD004928 Selenium deficiency
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0263912 BXGD005354 Rotator cuff syndrome Wounds and Injuries
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0338106 BXGD007167 Adenocarcinoma of colon Digestive System Diseases; Neoplasms
C0341106 BXGD007389 Eosinophilic esophagitis Digestive System Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0678356 BXGD009755 alcohol effect
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0747845 BXGD010184 early pregnancy
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0936016 BXGD011475 Testicular Feminization Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1153706 BXGD011769 Endometrial adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1262020 BXGD011864 Diffuse alveolar damage
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1275122 BXGD012060 Familial multiple trichoepitheliomata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C1292753 BXGD012226 Primary Effusion Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306759 BXGD012374 Eosinophilic disorder Hemic and Lymphatic Diseases
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1691215 BXGD013491 Penile hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1841972 BXGD014484 Glucocorticoid Receptor Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1849699 BXGD015078 Progesterone Resistance Female Urogenital Diseases and Pregnancy Complications
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2986665 BXGD018237 Early-Stage Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4048329 BXGD021904 Immunosuppression
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721773 BXGD023768 Postoperative cognitive dysfunction
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0033776 Cycloheximide 281.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein