Showing entry for Calcium/calmodulin-dependent protein kinase type II subunit gamma



                       
General Target Information
BXGT IdBXGT013375
Protein NameCalcium/calmodulin-dependent protein kinase type II subunit gamma
Uniport IdQ13555
GeneCAMK2G
Gene Id818
DomainCaMKII_AD; Pkinase
Pfam PF08332   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04012 ErbB signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04066 HIF-1 signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04114 Oocyte meiosis
4. Cellular Processes 4.2 Cell growth and death hsa04217 Necroptosis
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
3. Environmental Information Processing 3.2 Signal transduction hsa04310 Wnt signaling pathway
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.6 Nervous system hsa04720 Long-term potentiation
5. Organismal Systems 5.6 Nervous system hsa04722 Neurotrophin signaling pathway
5. Organismal Systems 5.6 Nervous system hsa04725 Cholinergic synapse
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
5. Organismal Systems 5.7 Sensory system hsa04740 Olfactory transduction
5. Organismal Systems 5.7 Sensory system hsa04750 Inflammatory mediator regulation of TRP channels
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.2 Endocrine system hsa04912 GnRH signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04916 Melanogenesis
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04922 Glucagon signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
6. Human Diseases 6.5 Substance dependence hsa05031 Amphetamine addiction
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05152 Tuberculosis
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05214 Glioma
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030073 insulin secretion
Biological Process GO:0060333 interferon-gamma-mediated signaling pathway
Biological Process GO:0051924 regulation of calcium ion transport
Biological Process GO:1900034 regulation of cellular response to heat
Biological Process GO:0010975 regulation of neuron projection development
Biological Process GO:0014733 regulation of skeletal muscle adaptation
molecular function GO:0005524 ATP binding
molecular function GO:0004723 calcium-dependent protein serine/threonine phosphatase activity
molecular function GO:0005516 calmodulin binding
molecular function GO:0004683 calmodulin-dependent protein kinase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0005954 calcium- and calmodulin-dependent protein kinase complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030666 endocytic vesicle membrane
cellular component GO:0016020 membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005654 nucleoplasm
cellular component GO:0033017 sarcoplasmic reticulum membrane
Reactome
Pathway Id Pathway Name
R-HSA-111885 Opioid Signalling
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB
R-HSA-111933 Calmodulin induced events
R-HSA-111996 Ca-dependent events
R-HSA-111997 CaM pathway
R-HSA-112040 G-protein mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1489509 DAG and IP3 signaling
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-212436 Generic Transcription Pathway
R-HSA-2262752 Cellular responses to stress
R-HSA-3371556 Cellular response to heat stress
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-372790 Signaling by GPCR
R-HSA-382551 Transport of small molecules
R-HSA-388396 GPCR downstream signalling
R-HSA-397014 Muscle contraction
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
R-HSA-418594 G alpha (i) signalling events
R-HSA-438064 Post NMDA receptor activation events
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5576891 Cardiac conduction
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5578775 Ion homeostasis
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5673000 RAF activation
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-877300 Interferon gamma signaling
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-8986944 Transcriptional Regulation by MECP2
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9022692 Regulation of MECP2 expression and activity
R-HSA-913531 Interferon Signaling
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-9607240 FLT3 Signaling
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission
R-HSA-9620244 Long-term potentiation
R-HSA-9649948 Signaling downstream of RAS mutants
R-HSA-9656223 Signaling by RAF1 mutants
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0016529 BXGD001068 Forced expiratory volume function
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0027092 BXGD001971 Myopia Eye Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0042834 BXGD003004 Vital capacity
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0239234 BXGD004974 Low set ears
C0239676 BXGD004989 High forehead
C0263361 BXGD005292 Psoriasis vulgaris Skin and Connective Tissue Diseases
C0280785 BXGD006760 Diffuse Astrocytoma Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0576226 BXGD009527 Short foot
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1275122 BXGD012060 Familial multiple trichoepitheliomata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1518922 BXGD013229 peak expiratory flow (procedure)
C1839758 BXGD014402 Narrow forehead
C1843108 BXGD014556 Short palm
C1845251 BXGD014734 Facial hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848673 BXGD014963 Hypoplastic feet
C1849340 BXGD015039 Long palpebral fissure
C1853241 BXGD015321 Flat face
C1855285 BXGD015483 Protruding ear
C1857485 BXGD015709 Flat forehead
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1865014 BXGD016282 Long philtrum
C1868571 BXGD016508 Highly arched eyebrow
C3150077 BXGD018291 Mild short stature
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4551854 BXGD023422 HYPOPLASTIC LEFT HEART SYNDROME 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4552072 BXGD023482 X-linked infantile spasms Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0000933 (-)-Arctigenin 372.41
BXGC0001940 Daphnetin 178.14
BXGC0002071 Apigenin 270.24
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0007052 Olomoucine 298.34
BXGC0012352 Chelerythrine 348.12
BXGC0012706 4-hydroxy-5-nitrophenyl acetic acid 197.03
BXGC0013582 Curcumin 368.13
BXGC0020911 Debromohymenialdisine 245.09
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0042870 Piceatannol 244.07
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
BXGC0051995 Wedelolactone 314.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein