Showing entry for Tyrosine-protein kinase ITK/TSK


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013012
Protein NameTyrosine-protein kinase ITK/TSK
Uniport IdQ08881
GeneITK
Gene Id3702
DomainBTK; PH; Pkinase_Tyr; SH2; SH3_1
Pfam PF00779   PF00169   PF07714   PF00017   PF00018  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04670 Leukocyte transendothelial migration
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007202 activation of phospholipase C activity
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0050853 B cell receptor signaling pathway
Biological Process GO:0006968 cellular defense response
Biological Process GO:0001816 cytokine production
Biological Process GO:0038095 Fc-epsilon receptor signaling pathway
Biological Process GO:0046629 gamma-delta T cell activation
Biological Process GO:0032609 interferon-gamma production
Biological Process GO:0032633 interleukin-4 production
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0001865 NK T cell differentiation
Biological Process GO:0038083 peptidyl-tyrosine autophosphorylation
Biological Process GO:0007165 signal transduction
Biological Process GO:0042110 T cell activation
Biological Process GO:0050852 T cell receptor signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004715 non-membrane spanning protein tyrosine kinase activity
cellular component GO:0005911 cell-cell junction
cellular component GO:0005829 cytosol
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168249 Innate Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-202403 TCR signaling
R-HSA-202433 Generation of second messenger molecules
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871809 FCERI mediated Ca+2 mobilization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004368 BXGD000271 Autoimmune state
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009447 BXGD000613 Common Variable Immunodeficiency Immune System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014522 BXGD000922 Epidermodysplasia Verruciformis Infections; Skin and Connective Tissue Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0020981 BXGD001474 Angioimmunoblastic Lymphadenopathy Immune System Diseases; Hemic and Lymphatic Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0023443 BXGD001648 Hairy Cell Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024291 BXGD001757 Lymphohistiocytosis, Hemophagocytic Hemic and Lymphatic Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024307 BXGD001765 Lymphomatoid Granulomatosis Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024314 BXGD001767 Lymphoproliferative Disorders Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027059 BXGD001965 Myocarditis Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033626 BXGD002412 Protein Deficiency Nutritional and Metabolic Diseases
C0035204 BXGD002511 Respiration Disorders Respiratory Tract Diseases
C0035242 BXGD002521 Respiratory Tract Diseases Respiratory Tract Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038362 BXGD002749 Stomatitis Stomatognathic Diseases
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079774 BXGD003101 Peripheral T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0086438 BXGD003283 Hypogammaglobulinemia Immune System Diseases; Hemic and Lymphatic Diseases
C0149630 BXGD003334 Bicuspid aortic valve Cardiovascular Diseases
C0149678 BXGD003346 Epstein-Barr Virus Infections Infections
C0151632 BXGD003450 ESR raised
C0155490 BXGD003795 Middle Ear Cholesteatoma Skin and Connective Tissue Diseases; Otorhinolaryngologic Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0206180 BXGD004170 Ki-1+ Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220644 BXGD004306 Childhood Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0221026 BXGD004371 X-linked agammaglobulinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0233849 BXGD004621 Personality Traits Behavior and Behavior Mechanisms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239998 BXGD005012 Recurrent infections Pathological Conditions, Signs and Symptoms; Infections; Musculoskeletal Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0334619 BXGD007142 HODGKIN'S AND NON-HODGKIN'S LYMPHOMA
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0395886 BXGD008171 Cholesteatoma, Congenital Skin and Connective Tissue Diseases
C0472817 BXGD008928 WHIM syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infections; Skin and Connective Tissue Diseases; Immune System Diseases
C0494261 BXGD009023 Combined immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0549463 BXGD009382 X-Linked Lymphoproliferative Disorder Immune System Diseases; Hemic and Lymphatic Diseases
C0549523 BXGD009386 Oropharynx (excludes nasopharynx)
C0585362 BXGD009592 Squamous cell carcinoma of mouth Digestive System Diseases; Neoplasms; Stomatognathic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0730328 BXGD009959 Central Serous Chorioretinopathy Eye Diseases
C0796074 BXGD010793 MOHR-TRANEBJAERG SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Mental Disorders; Otorhinolaryngologic Diseases; Behavior and Behavior Mechanisms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1275122 BXGD012060 Familial multiple trichoepitheliomata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332078 BXGD012485 Anaplastic large cell lymphoma, ALK negative Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1333064 BXGD012587 Classical Hodgkin's Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1654637 BXGD013484 androgen independent prostate cancer
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1842981 BXGD014547 NEUROTICISM Behavior and Behavior Mechanisms
C2347747 BXGD017040 Adult Classical Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2751686 BXGD017734 Lymphoproliferative Syndrome, Ebv-Associated, Autosomal, 1 Immune System Diseases; Hemic and Lymphatic Diseases
C2936664 BXGD018125 Acquired Hypogammaglobulinemia Immune System Diseases
C2937365 BXGD018161 Recurrent aphthous ulcer Stomatognathic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3495949 BXGD019016 Locally advanced breast cancer
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3552634 BXGD019158 LYMPHOPROLIFERATIVE SYNDROME 1
C3642347 BXGD019246 Basal-Like Breast Carcinoma
C3887558 BXGD019899 Hemophagocytic Syndrome Hemic and Lymphatic Diseases
C4283841 BXGD022425 ITK Deficiency Immune System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0004580 Carbanilide 212.25
BXGC0004705 Diphenylamine 169.22
BXGC0012352 Chelerythrine 348.12
BXGC0017933 Sulfuretin 270.05
BXGC0023872 Adenine 135.05
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein