Showing entry for Beta-adrenergic receptor kinase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009015
Protein NameBeta-adrenergic receptor kinase 1
Uniport IdP25098
GeneGRK2
Gene Id156
DomainPH; Pkinase; RGS
Pfam PF00169   PF00069   PF00615  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
3. Environmental Information Processing 3.2 Signal transduction hsa04340 Hedgehog signaling pathway
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
5. Organismal Systems 5.7 Sensory system hsa04740 Olfactory transduction
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0002029 desensitization of G protein-coupled receptor signaling pathway
Biological Process GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007507 heart development
Biological Process GO:1901081 negative regulation of relaxation of smooth muscle
Biological Process GO:0045988 negative regulation of striated muscle contraction
Biological Process GO:0003108 negative regulation of the force of heart contraction by chemical signal
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0033605 positive regulation of catecholamine secretion
Biological Process GO:0031623 receptor internalization
Biological Process GO:0007217 tachykinin receptor signaling pathway
Biological Process GO:0046718 viral entry into host cell
Biological Process GO:0019079 viral genome replication
molecular function GO:0031694 alpha-2A adrenergic receptor binding
molecular function GO:0005524 ATP binding
molecular function GO:0047696 beta-adrenergic receptor kinase activity
molecular function GO:0031755 Edg-2 lysophosphatidic acid receptor binding
molecular function GO:0004703 G protein-coupled receptor kinase activity
molecular function GO:0004672 protein kinase activity
cellular component GO:0005929 cilium
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-111885 Opioid Signalling
R-HSA-111933 Calmodulin induced events
R-HSA-111996 Ca-dependent events
R-HSA-111997 CaM pathway
R-HSA-112040 G-protein mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-1489509 DAG and IP3 signaling
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-199991 Membrane Trafficking
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5635838 Activation of SMO
R-HSA-5635838 Activation of SMO
R-HSA-5653656 Vesicle-mediated transport
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9006925 Intracellular signaling by second messengers
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001206 BXGD000033 Acromegaly Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011616 BXGD000739 Contact Dermatitis Skin and Connective Tissue Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0012684 BXGD000781 Blastocyst Disintegration Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0013937 BXGD000871 Embryo Resorption Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0020428 BXGD001377 Hyperaldosteronism Endocrine System Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020541 BXGD001424 Portal Hypertension Digestive System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033141 BXGD002400 Cardiomyopathies, Primary Cardiovascular Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036529 BXGD002624 Myocardial Diseases, Secondary Cardiovascular Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040137 BXGD002846 Thyroid Nodule Neoplasms; Endocrine System Diseases
C0040411 BXGD002859 Tongue Neoplasms Neoplasms; Stomatognathic Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042769 BXGD002999 Virus Diseases Infections
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152021 BXGD003520 Congenital heart disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0158570 BXGD003892 Vascular anomaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0162770 BXGD003980 Right Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162820 BXGD003985 Dermatitis, Allergic Contact Skin and Connective Tissue Diseases; Immune System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0235782 BXGD004769 Gallbladder Carcinoma Digestive System Diseases; Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239849 BXGD005003 Harlequin Fetus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0264716 BXGD005417 Chronic heart failure Cardiovascular Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279530 BXGD006628 Malignant Bone Neoplasm Neoplasms; Musculoskeletal Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349782 BXGD007954 Ischemic cardiomyopathy Cardiovascular Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392164 BXGD008031 Pulmonary Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0392514 BXGD008051 Hereditary hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0393642 BXGD008111 Sepsis-Associated Encephalopathy Nervous System Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0496870 BXGD009044 Benign neoplasm of liver Digestive System Diseases; Neoplasms
C0520540 BXGD009088 Rebound hypertension Cardiovascular Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0563625 BXGD009484 Agnosia for Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0679309 BXGD009765 physical symptom
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751783 BXGD010592 Lafora Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751967 BXGD010657 Multiple Sclerosis, Relapsing-Remitting Immune System Diseases; Nervous System Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0752350 BXGD010722 Embryo Death Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0752351 BXGD010723 Embryo Loss Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0853897 BXGD010985 Diabetic Cardiomyopathies Endocrine System Diseases; Cardiovascular Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0856742 BXGD011111 Post MI Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1134719 BXGD011688 Invasive Ductal Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1135191 BXGD011692 Heart Failure, Systolic Cardiovascular Diseases
C1136082 BXGD011707 Embryo Disintegration Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1273070 BXGD012018 Left ventricular diastolic dysfunction Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1337013 BXGD012876 Differentiated Thyroid Gland Carcinoma
C1383860 BXGD012935 Cardiac Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1510885 BXGD013178 Angiogenic Switch
C1719788 BXGD013661 Episodic ataxia type 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1739395 BXGD013739 Takotsubo Cardiomyopathy Cardiovascular Diseases
C1840311 BXGD014445 Laryngeal cleft Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1849157 BXGD015018 Resistance to Insulin-Like Growth Factor I Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C1997092 BXGD016858 Hypertensive left ventricular hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2004489 BXGD016873 Regurgitation
C2062441 BXGD016897 Influenza A
C2118460 BXGD016927 Acute colitis Digestive System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2732618 BXGD017556 Sessile Serrated Adenoma/Polyp
C2747816 BXGD017577 Complicated malaria Infections
C2945695 BXGD018187 Limb ischemia
C3160909 BXGD018497 Autoimmune arthritis
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4525297 BXGD023131 Stage 0 Gallbladder Cancer AJCC v8
C4525300 BXGD023132 Stage IIA Gallbladder Cancer AJCC v8
C4525301 BXGD023133 Stage IIB Gallbladder Cancer AJCC v8
C4525302 BXGD023134 Stage III Gallbladder Cancer AJCC v8
C4525305 BXGD023135 Stage IV Gallbladder Cancer AJCC v8
C4529962 BXGD023178 Fatty Liver Disease
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0042339 Terbutaline 225.14
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
BXGC0052402 cyclic gmp 345.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein