Showing entry for Acyl-CoA (8-3)-desaturase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004875
Protein NameAcyl-CoA (8-3)-desaturase
Uniport IdO60427
GeneFADS1
Gene Id3992
DomainCyt-b5; FA_desaturase
Pfam PF00173   PF00487  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa01040 Biosynthesis of unsaturated fatty acids
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01212 Fatty acid metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0036109 alpha-linolenic acid metabolic process
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0046456 icosanoid biosynthetic process
Biological Process GO:0043651 linoleic acid metabolic process
Biological Process GO:0042759 long-chain fatty acid biosynthetic process
Biological Process GO:0008654 phospholipid biosynthetic process
Biological Process GO:0045595 regulation of cell differentiation
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0006636 unsaturated fatty acid biosynthetic process
molecular function GO:0062076 acyl-CoA delta5-desaturase activity
molecular function GO:0000248 C-5 sterol desaturase activity
molecular function GO:0016213 linoleoyl-CoA desaturase activity
molecular function GO:0045485 omega-6 fatty acid desaturase activity
molecular function GO:0016491 oxidoreductase activity
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0016020 membrane
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1989781 PPARA activates gene expression
R-HSA-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
R-HSA-2046105 Linoleic acid (LA) metabolism
R-HSA-2046106 alpha-linolenic acid (ALA) metabolism
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0006012 BXGD000360 Borderline Personality Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018810 BXGD001231 heart rate
C0018935 BXGD001252 Hematocrit procedure
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032181 BXGD002332 Platelet Count measurement
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0043094 BXGD003026 Weight Gain Pathological Conditions, Signs and Symptoms
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0200633 BXGD004040 Neutrophil count (procedure)
C0200638 BXGD004043 Eosinophil count procedure
C0200641 BXGD004044 Blood basophil count (lab test)
C0200665 BXGD004045 Platelet mean volume determination (procedure)
C0201657 BXGD004051 C-reactive protein measurement
C0201836 BXGD004052 Alanine aminotransferase measurement
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202171 BXGD004077 Phosphatidylinositol measurement
C0202177 BXGD004079 Phospholipid measurement
C0202236 BXGD004086 Triglycerides measurement
C0220641 BXGD004305 Lip and Oral Cavity Carcinoma Neoplasms; Stomatognathic Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236773 BXGD004827 Depressed bipolar I disorder Mental Disorders
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242216 BXGD005141 Biliary calculi Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0337438 BXGD007159 Glucose measurement
C0339528 BXGD007261 X-linked retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0424574 BXGD008534 Duration of sleep
C0427460 BXGD008616 Red cell distribution width determination
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0428568 BXGD008633 Fasting blood glucose measurement
C0428883 BXGD008639 Diastolic blood pressure
C0429028 BXGD008646 QT interval feature (observable entity)
C0432215 BXGD008739 Progressive pseudorheumatoid dysplasia Musculoskeletal Diseases
C0495706 BXGD009038 elevated blood glucose level
C0523465 BXGD009209 Serum albumin measurement
C0523744 BXGD009217 Lipids measurement
C0523829 BXGD009221 Phosphatidylcholine measurement
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0857490 BXGD011150 Granulocyte count
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0871470 BXGD011316 Systolic Pressure
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1261430 BXGD011853 Fasting blood sugar result
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1281901 BXGD012133 Fatty acid measurement
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1821417 BXGD013764 RESTING HEART RATE
C1832200 BXGD013810 Peroxisome biogenesis disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1883008 BXGD016593 Serum Alanine Aminotransferase Measurement
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316832 BXGD017031 Arachidonic acid measurement
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3662483 BXGD019270 Allergic sensitization
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4529962 BXGD023178 Fatty Liver Disease
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006107 alpha-Linolenic acid 278.43
BXGC0014782 Icosapent 302.22
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein