Showing entry for Carbamoyl-phosphate synthase [ammonia], mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009523
Protein NameCarbamoyl-phosphate synthase [ammonia], mitochondrial
Uniport IdP31327
GeneCPS1
Gene Id1373
DomainCPSase_C; CPSase_L_D2; CPSase_L_D3; CPSase_sm_chain; GATase; MGS
Pfam PF18302   PF02786   PF02787   PF00988   PF00117   PF02142  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00220 Arginine biosynthesis
1. Metabolism 1.5 Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism
1. Metabolism 1.2 Energy metabolism hsa00910 Nitrogen metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
1. Metabolism 1.0 Global and overview maps hsa01230 Biosynthesis of amino acids
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
Biological Process GO:0055081 anion homeostasis
Biological Process GO:0070409 carbamoyl phosphate biosynthetic process
Biological Process GO:1903718 cellular response to ammonia
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0044344 cellular response to fibroblast growth factor stimulus
Biological Process GO:0071377 cellular response to glucagon stimulus
Biological Process GO:0071400 cellular response to oleic acid
Biological Process GO:0019240 citrulline biosynthetic process
Biological Process GO:0006541 glutamine metabolic process
Biological Process GO:0070365 hepatocyte differentiation
Biological Process GO:0050667 homocysteine metabolic process
Biological Process GO:0007494 midgut development
Biological Process GO:0046209 nitric oxide metabolic process
Biological Process GO:0006807 nitrogen compound metabolic process
Biological Process GO:0014075 response to amine
Biological Process GO:0043200 response to amino acid
Biological Process GO:0071548 response to dexamethasone
Biological Process GO:0042493 response to drug
Biological Process GO:0032094 response to food
Biological Process GO:0060416 response to growth hormone
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0042594 response to starvation
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0010043 response to zinc ion
Biological Process GO:0019433 triglyceride catabolic process
Biological Process GO:0000050 urea cycle
Biological Process GO:0042311 vasodilation
molecular function GO:0005524 ATP binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0004087 carbamoyl-phosphate synthase (ammonia) activity
molecular function GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
molecular function GO:0004175 endopeptidase activity
molecular function GO:0016595 glutamate binding
molecular function GO:0072341 modified amino acid binding
molecular function GO:0005543 phospholipid binding
molecular function GO:0044877 protein-containing complex binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0042645 mitochondrial nucleoid
cellular component GO:0005730 nucleolus
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-70635 Urea cycle
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001122 BXGD000023 Acidosis Nutritional and Metabolic Diseases
C0001925 BXGD000090 Albuminuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0002064 BXGD000100 Alkalosis, Respiratory Nutritional and Metabolic Diseases; Respiratory Tract Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005845 BXGD000341 Blood urea nitrogen measurement
C0005890 BXGD000345 Body Height
C0006114 BXGD000371 Cerebral Edema Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009421 BXGD000608 Comatose Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010414 BXGD000669 Infection by Cryptococcus neoformans Infections
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015696 BXGD001014 Fatty Liver, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017654 BXGD001136 Glomerular Filtration Rate
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019188 BXGD001297 Hepatitis, Animal Digestive System Diseases; Infections; Animal Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0019360 BXGD001327 Herpes zoster disease Infections
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023380 BXGD001640 Lethargy Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0023508 BXGD001675 White Blood Cell Count procedure
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023904 BXGD001721 Liver Neoplasms, Experimental Digestive System Diseases; Neoplasms
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0031190 BXGD002293 Persistent Fetal Circulation Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0032181 BXGD002332 Platelet Count measurement
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032768 BXGD002370 Postherpetic neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0154246 BXGD003709 Urea Cycle Disorders, Inborn Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200638 BXGD004043 Eosinophil count procedure
C0200665 BXGD004045 Platelet mean volume determination (procedure)
C0201836 BXGD004052 Alanine aminotransferase measurement
C0201874 BXGD004054 Amino acids measurement
C0201976 BXGD004063 Creatinine measurement, serum (procedure)
C0202202 BXGD004082 Protein measurement
C0202239 BXGD004087 Uric acid measurement (procedure)
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220994 BXGD004357 Hyperammonemia Pathological Conditions, Signs and Symptoms
C0238621 BXGD004947 Aminoaciduria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0268130 BXGD005829 Hereditary orotic aciduria, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0268540 BXGD005976 HHH syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268542 BXGD005977 Ornithine carbamoyltransferase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0282313 BXGD006803 Condition, Preneoplastic Neoplasms
C0337428 BXGD007155 Fibrinogen assay
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0392885 BXGD008071 High density lipoprotein measurement
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0424678 BXGD008537 Lean body mass
C0427460 BXGD008616 Red cell distribution width determination
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0520459 BXGD009084 Necrotizing Enterocolitis Digestive System Diseases
C0523465 BXGD009209 Serum albumin measurement
C0523677 BXGD009215 Glycine measurement
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740380 BXGD009983 Varicella zoster
C0751753 BXGD010576 Carbamoyl-Phosphate Synthase I Deficiency Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0860634 BXGD011239 Psychogenic coma Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0871470 BXGD011316 Systolic Pressure
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1325327 BXGD012455 fibrinogen activity
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1561955 BXGD013367 Fibrinogen, CTCAE
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1839531 BXGD014381 Protein avoidance
C1839532 BXGD014382 Low plasma citrulline
C1839541 BXGD014384 Episodic ammonia intoxication
C1883008 BXGD016593 Serum Alanine Aminotransferase Measurement
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2242817 BXGD017005 Homocysteine measurement
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3714958 BXGD019441 PULMONARY HYPERTENSION, NEONATAL, SUSCEPTIBILITY TO
C4025095 BXGD021556 Hypoargininemia
C4049919 BXGD021955 Insulin Sensitivity Measurement
C4082171 BXGD022085 Hyperammonemia Due to Carbamoyl Phosphate Synthetase 1 Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C4082937 BXGD022095 Necrotizing enterocolitis in fetus OR newborn Digestive System Diseases
C4085580 BXGD022117 Carbamoyl Phosphate Synthase 1 Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4284013 BXGD022428 Primary cholangiocarcinoma of intrahepatic biliary tract Neoplasms
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4552810 BXGD023525 Irritability, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000968 Glutaric acid 132.11
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
BXGC0003705 Chloride 35.45
BXGC0004284 Hexanedioic acid 146.14
BXGC0004560 Benzoic acid 122.12
BXGC0019951 (S)-(-)-Methylsuccinic acid 132.04
BXGC0035046 Acetylglutamic Acid 189.06
BXGC0048978 (R)-(+)-Methylsuccinic acid 132.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein