Showing entry for Protein crumbs homolog 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011972
Protein NameProtein crumbs homolog 1
Uniport IdP82279
GeneCRB1
Gene Id23418
DomainEGF; hEGF; Laminin_G_2
Pfam PF00008   PF12661   PF02210  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001974 blood vessel remodeling
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0007163 establishment or maintenance of cell polarity
Biological Process GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
Biological Process GO:0042462 eye photoreceptor cell development
Biological Process GO:0010001 glial cell differentiation
Biological Process GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Process GO:0045494 photoreceptor cell maintenance
Biological Process GO:0035845 photoreceptor cell outer segment organization
Biological Process GO:0007009 plasma membrane organization
Biological Process GO:0060060 post-embryonic retina morphogenesis in camera-type eye
Biological Process GO:0007601 visual perception
molecular function GO:0005509 calcium ion binding
cellular component GO:0005912 adherens junction
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005576 extracellular region
cellular component GO:0016021 integral component of membrane
cellular component GO:0005902 microvillus
cellular component GO:0001917 photoreceptor inner segment
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009447 BXGD000613 Common Variable Immunodeficiency Immune System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014065 BXGD000884 Congenital cerebral hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014877 BXGD000967 Esotropia Eye Diseases; Nervous System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020490 BXGD001403 Hyperopia Eye Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024440 BXGD001774 Macular Edema, Cystoid Eye Diseases
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035305 BXGD002529 Retinal Detachment Eye Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0149745 BXGD003356 Oral Ulcer Stomatognathic Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152200 BXGD003557 Achromatopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0154832 BXGD003747 Exudative retinopathy Eye Diseases; Cardiovascular Diseases
C0154835 BXGD003748 Retinal telangiectasia Cardiovascular Diseases
C0154860 BXGD003752 Hereditary retinal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0202123 BXGD004075 Luteinizing hormone measurement
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0271091 BXGD006160 Retinoschisis, Juvenile, X-Linked Eye Diseases
C0271093 BXGD006162 Stargardt's disease
C0271388 BXGD006196 Pendular Nystagmus Eye Diseases; Nervous System Diseases
C0339508 BXGD007256 Hereditary macular dystrophy
C0339526 BXGD007259 Autosomal recessive retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0339527 BXGD007260 Leber Congenital Amaurosis Eye Diseases
C0339546 BXGD007268 Retinal Pigment Epithelial Detachment Eye Diseases
C0344290 BXGD007662 Vitreoretinal degeneration
C0375206 BXGD007973 Hemiplegia/hemiparesis
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0523688 BXGD009216 Hemopexin measurement
C0557874 BXGD009444 Global developmental delay
C0730292 BXGD009947 Macular dystrophy Eye Diseases
C0730362 BXGD009961 Disorder of macula of retina Eye Diseases
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C0871470 BXGD011316 Systolic Pressure
C0920350 BXGD011466 Autoimmune thyroiditis Immune System Diseases; Endocrine System Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1285162 BXGD012167 Degenerative disorder Pathological Conditions, Signs and Symptoms
C1301509 BXGD012294 Severe visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C1305855 BXGD012348 Body mass index
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1836926 BXGD014179 Bone spicule pigmentation of the retina
C1837249 BXGD014210 Malformations of Cortical Development, Group II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1837352 BXGD014223 Childhood onset
C1838647 BXGD014329 RETINITIS PIGMENTOSA 12 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1840077 BXGD014434 Anteverted nostril
C1848172 BXGD014908 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1849367 BXGD015046 Nasal bridge wide
C1849394 BXGD015048 Enhanced S-Cone Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1849397 BXGD015049 Retinoschisis of Fovea Eye Diseases
C1849792 BXGD015085 Achromatopsia 3 Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C1855465 BXGD015498 STARGARDT DISEASE 1 (disorder)
C1855676 BXGD015528 Aplasia/Hypoplasia of the cerebellar vermis
C1855685 BXGD015531 Undetectable electroretinogram
C1855925 BXGD015561 Hyperopia, High Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1858080 BXGD015768 Retinal Dystrophy, Early Onset Severe Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1868310 BXGD016496 Pigmented Paravenous Chorioretinal Atrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1998028 BXGD016865 Photoreceptor degeneration Eye Diseases
C2239219 BXGD016966 von Willebrand's factor (lab test)
C2931258 BXGD017991 Amaurosis congenita of Leber, type 1 Eye Diseases
C2932677 BXGD018097 Idiopathic Juxtafoveal Retinal Telangiectasia Eye Diseases; Cardiovascular Diseases
C3150797 BXGD018337 AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
C3151202 BXGD018406 LEBER CONGENITAL AMAUROSIS 8
C3275758 BXGD018675 Choriocapillaris atrophy
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3540662 BXGD019091 Congenital Amaurosis of Retinal Origin Eye Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3808249 BXGD019541 Abnormality of the optic disc
C3888198 BXGD019958 BESTROPHINOPATHY, AUTOSOMAL RECESSIVE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4014795 BXGD020166 AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
C4021786 BXGD020779 Atypical scarring of skin Pathological Conditions, Signs and Symptoms
C4024818 BXGD021428 Progressive night blindness Eye Diseases
C4072868 BXGD022007 Paravenous chorioretinal atrophy
C4085590 BXGD022119 Cone-Rod Dystrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4310768 BXGD022658 AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein