Showing entry for Lysine--tRNA ligase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013527
Protein NameLysine--tRNA ligase
Uniport IdQ15046
GeneKARS1
Gene Id3735
DomaintRNA-synt_2; tRNA_anti-codon
Pfam PF00152   PF01336  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa00970 Aminoacyl-tRNA biosynthesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0002276 basophil activation involved in immune response
Biological Process GO:0015966 diadenosine tetraphosphate biosynthetic process
Biological Process GO:0070371 ERK1 and ERK2 cascade
Biological Process GO:0006430 lysyl-tRNA aminoacylation
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0002720 positive regulation of cytokine production involved in immune response
Biological Process GO:1900017 positive regulation of cytokine production involved in inflammatory response
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0043032 positive regulation of macrophage activation
Biological Process GO:0010759 positive regulation of macrophage chemotaxis
Biological Process GO:1905050 positive regulation of metallopeptidase activity
Biological Process GO:1900745 positive regulation of p38MAPK cascade
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0010165 response to X-ray
Biological Process GO:0006418 tRNA aminoacylation for protein translation
Biological Process GO:0008033 tRNA processing
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
Biological Process GO:0016032 viral process
molecular function GO:0016597 amino acid binding
molecular function GO:0003877 ATP adenylyltransferase activity
molecular function GO:0005524 ATP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0004824 lysine-tRNA ligase activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0000049 tRNA binding
cellular component GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
cellular component GO:0005829 cytosol
cellular component GO:0005615 extracellular space
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2408522 Selenoamino acid metabolism
R-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-379724 tRNA Aminoacylation
R-HSA-379726 Mitochondrial tRNA aminoacylation
R-HSA-392499 Metabolism of proteins
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-72766 Translation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001125 BXGD000024 Acidosis, Lactic Nutritional and Metabolic Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0010418 BXGD000671 Cryptosporidiosis Digestive System Diseases; Infections; Animal Diseases
C0011633 BXGD000742 Dermatomyositis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0024198 BXGD001743 Lyme Disease Infections
C0024530 BXGD001783 Malaria Infections
C0025202 BXGD001832 melanoma Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027859 BXGD002052 Acoustic Neuroma Neoplasms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0029132 BXGD002117 Disorder of the optic nerve Eye Diseases; Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0042798 BXGD003003 Low Vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0085655 BXGD003226 Polymyositis Musculoskeletal Diseases; Nervous System Diseases
C0149940 BXGD003391 Sciatic Neuropathy Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152025 BXGD003521 Polyneuropathy Nervous System Diseases
C0162534 BXGD003953 Prion Diseases Infections; Nervous System Diseases
C0221056 BXGD004383 Adult type dermatomyositis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0393525 BXGD008081 Progressive cerebellar ataxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0427149 BXGD008608 Gait, Drop Foot Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C0752100 BXGD010661 Autosomal Recessive Parkinsonism Nervous System Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0948163 BXGD011511 Leukoaraiosis Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1847640 BXGD014879 KUFOR-RAKEB SYNDROME Nervous System Diseases
C1865866 BXGD016345 Congenital sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1866141 BXGD016379 Foot dorsiflexor weakness
C2363741 BXGD017100 HIV-1 infection
C3150897 BXGD018349 CHARCOT-MARIE-TOOTH DISEASE, RECESSIVE INTERMEDIATE B
C3151351 BXGD018418 DEAFNESS, AUTOSOMAL RECESSIVE 89
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3711374 BXGD019382 Nonsyndromic Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887709 BXGD019918 Optic Neuropathy Eye Diseases; Nervous System Diseases
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000218 L-Lysine 146.19
BXGC0000279 L-Alanine 89.09
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0014055 18-Oxoferruginol 300.21
BXGC0014116 Lysine 147.11
BXGC0016254 Dehydroabietic Acid 300.21
BXGC0029198 Pomiferin A 286.23
BXGC0053231 15-hydroxydehydroabietic acid 316.2
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein