Showing entry for Vacuolar protein sorting-associated protein 35


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019720
Protein NameVacuolar protein sorting-associated protein 35
Uniport IdQ96QK1
GeneVPS35
Gene Id55737
DomainVps35
Pfam PF03635  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0007040 lysosome organization
Biological Process GO:0043653 mitochondrial fragmentation involved in apoptotic process
Biological Process GO:0099074 mitochondrion to lysosome transport
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:1903828 negative regulation of cellular protein localization
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:1902823 negative regulation of late endosome to lysosome transport
Biological Process GO:1905166 negative regulation of lysosomal protein catabolic process
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:0032463 negative regulation of protein homooligomerization
Biological Process GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane
Biological Process GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:1903364 positive regulation of cellular protein catabolic process
Biological Process GO:1903181 positive regulation of dopamine biosynthetic process
Biological Process GO:0060161 positive regulation of dopamine receptor signaling pathway
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0090326 positive regulation of locomotion involved in locomotory behavior
Biological Process GO:0090141 positive regulation of mitochondrial fission
Biological Process GO:0061357 positive regulation of Wnt protein secretion
Biological Process GO:0031648 protein destabilization
Biological Process GO:0036010 protein localization to endosome
Biological Process GO:0032268 regulation of cellular protein metabolic process
Biological Process GO:1902950 regulation of dendritic spine maintenance
Biological Process GO:0016241 regulation of macroautophagy
Biological Process GO:0010821 regulation of mitochondrion organization
Biological Process GO:1905606 regulation of presynapse assembly
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:2000331 regulation of terminal button organization
Biological Process GO:0042147 retrograde transport, endosome to Golgi
Biological Process GO:1990126 retrograde transport, endosome to plasma membrane
Biological Process GO:0045056 transcytosis
Biological Process GO:0099003 vesicle-mediated transport in synapse
Biological Process GO:0016032 viral process
Biological Process GO:0050882 voluntary musculoskeletal movement
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0031748 D1 dopamine receptor binding
cellular component GO:0005829 cytosol
cellular component GO:0005769 early endosome
cellular component GO:0005768 endosome
cellular component GO:0010008 endosome membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005770 late endosome
cellular component GO:0005765 lysosomal membrane
cellular component GO:0005764 lysosome
cellular component GO:0099073 mitochondrion-derived vesicle
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0014069 postsynaptic density
cellular component GO:0098793 presynapse
cellular component GO:0030906 retromer, cargo-selective complex
cellular component GO:0030904 retromer complex
cellular component GO:0097422 tubular endosome
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-195721 Signaling by WNT
R-HSA-3238698 WNT ligand biogenesis and trafficking
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010036 BXGD000642 Corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012569 BXGD000777 Diplopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0043194 BXGD003036 Wiskott-Aldrich Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0085623 BXGD003210 Akinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085632 BXGD003215 Apathy Behavior and Behavior Mechanisms
C0231688 BXGD004510 Gait, Shuffling Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233401 BXGD004575 Psychiatric symptom
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233763 BXGD004611 Hallucinations, Visual Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234379 BXGD004662 Resting Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0270736 BXGD006096 Essential Tremor Nervous System Diseases
C0401149 BXGD008273 Chronic constipation Pathological Conditions, Signs and Symptoms
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0548883 BXGD009356 Low frustration tolerance Behavior and Behavior Mechanisms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0813217 BXGD010854 Expressionless face Nervous System Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1285162 BXGD012167 Degenerative disorder Pathological Conditions, Signs and Symptoms
C1611743 BXGD013456 Familial (FPAH)
C1836904 BXGD014176 Spastic/hyperactive bladder
C1843921 BXGD014620 Postural instability Nervous System Diseases
C1846868 BXGD014846 Parkinsonism with favorable response to dopaminergic medication Nervous System Diseases
C1868528 BXGD016503 Orthostatic hypotension due to autonomic dysfunction Nervous System Diseases; Cardiovascular Diseases
C1868596 BXGD016513 Atypical Parkinson Disease Nervous System Diseases
C1963060 BXGD016679 Agitation, CTCAE 3.0
C2364082 BXGD017123 Sense of smell impaired Nervous System Diseases
C3160718 BXGD018468 PARKINSON DISEASE, LATE-ONSET
C3280133 BXGD018808 PARKINSON DISEASE 17
C3489791 BXGD018949 Parkinson Disease, Familial, Type 1 Nervous System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4274355 BXGD022352 Autosomal dominant late onset Parkinson disease Nervous System Diseases
C4302185 BXGD022525 Atypical Parkinsonism Nervous System Diseases
C4511452 BXGD023002 Sporadic Parkinson disease Nervous System Diseases
C4531121 BXGD023189 Monotonic speech
C4551583 BXGD023361 Cerebral cortical atrophy
C4552855 BXGD023528 Agitation, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein