Showing entry for Neutrophil cytosol factor 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008024
Protein NameNeutrophil cytosol factor 1
Uniport IdP14598
GeneNCF1
Gene Id653361
DomainNECFESHC; p47_phox_C; PX; SH3_1
Pfam PF16621   PF08944   PF00787   PF00018  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
5. Organismal Systems 5.8 Development hsa04380 Osteoclast differentiation
5. Organismal Systems 5.1 Immune system hsa04666 Fc gamma R-mediated phagocytosis
5. Organismal Systems 5.1 Immune system hsa04670 Leukocyte transendothelial migration
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05140 Leishmaniasis
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
Biological Process GO:0006915 apoptotic process
Biological Process GO:0045454 cell redox homeostasis
Biological Process GO:0006968 cellular defense response
Biological Process GO:0071276 cellular response to cadmium ion
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0045087 innate immune response
Biological Process GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:1900745 positive regulation of p38MAPK cascade
Biological Process GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0006612 protein targeting to membrane
Biological Process GO:0045730 respiratory burst
Biological Process GO:0042554 superoxide anion generation
Biological Process GO:0006801 superoxide metabolic process
Biological Process GO:0048010 vascular endothelial growth factor receptor signaling pathway
molecular function GO:0009055 electron transfer activity
molecular function GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
molecular function GO:0032266 phosphatidylinositol-3-phosphate binding
molecular function GO:0035091 phosphatidylinositol binding
molecular function GO:0017124 SH3 domain binding
molecular function GO:0016176 superoxide-generating NADPH oxidase activator activity
molecular function GO:0016175 superoxide-generating NADPH oxidase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0019898 extrinsic component of membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016020 membrane
cellular component GO:0043020 NADPH oxidase complex
cellular component GO:0043025 neuronal cell body
cellular component GO:0032010 phagolysosome
cellular component GO:0005886 plasma membrane
cellular component GO:0005791 rough endoplasmic reticulum
Reactome
Pathway Id Pathway Name
R-HSA-1222556 ROS and RNS production in phagocytes
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-194138 Signaling by VEGF
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-2262752 Cellular responses to stress
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002152 BXGD000104 Alloxan Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002893 BXGD000150 Refractory anemias Hemic and Lymphatic Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005136 BXGD000305 Berry Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0005699 BXGD000325 Blast Phase Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0005859 BXGD000342 Bloom Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007621 BXGD000468 Neoplastic Cell Transformation Pathological Conditions, Signs and Symptoms; Neoplasms
C0007642 BXGD000469 Cellulitis Pathological Conditions, Signs and Symptoms; Infections; Skin and Connective Tissue Diseases
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011311 BXGD000714 Dengue Fever Infections
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013575 BXGD000854 Ectodermal Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014836 BXGD000954 Escherichia coli Infections Infections
C0015302 BXGD000974 External exotoses Musculoskeletal Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017574 BXGD001122 Gingivitis Infections; Stomatognathic Diseases
C0018203 BXGD001184 Chronic granulomatous disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020672 BXGD001461 Hypothermia, natural Pathological Conditions, Signs and Symptoms
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022650 BXGD001568 Kidney Calculi Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023479 BXGD001663 Acute myelomonocytic leukemia Neoplasms
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023885 BXGD001711 Liver Abscess Digestive System Diseases; Infections
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024205 BXGD001744 Lymphadenitis Hemic and Lymphatic Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0024530 BXGD001783 Malaria Infections
C0024535 BXGD001785 Malaria, Falciparum Infections
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029443 BXGD002152 Osteomyelitis Infections; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029458 BXGD002158 Osteoporosis, Postmenopausal Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029882 BXGD002177 Otitis Media Otorhinolaryngologic Diseases
C0030499 BXGD002232 Parasitic Diseases Infections
C0031485 BXGD002303 Phenylketonurias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0034194 BXGD002472 Pyloric Stenosis Digestive System Diseases
C0035435 BXGD002549 Rheumatism Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037199 BXGD002671 Sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0037299 BXGD002685 Skin Ulcer Skin and Connective Tissue Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038433 BXGD002754 Streptozotocin Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0040588 BXGD002879 Tracheoesophageal Fistula Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Respiratory Tract Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0086981 BXGD003317 Sicca Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0149770 BXGD003359 Rectal abscess Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Infections
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0175697 BXGD004004 Van der Woude syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases; Stomatognathic Diseases
C0175702 BXGD004008 Williams Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0221026 BXGD004371 X-linked agammaglobulinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242380 BXGD005158 Libman-Sacks Disease Skin and Connective Tissue Diseases; Immune System Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0276447 BXGD006425 Rhinovirus infection Infections
C0349506 BXGD007912 Photosensitivity of skin Skin and Connective Tissue Diseases
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392525 BXGD008052 Nephrolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0398689 BXGD008216 Hyper-IgM Immunodeficiency Syndrome, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0427515 BXGD008619 Neutrophil abnormality
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0520743 BXGD009107 Mediastinal lymphadenopathy Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0521173 BXGD009132 Granulomatosis
C0549463 BXGD009382 X-Linked Lymphoproliferative Disorder Immune System Diseases; Hemic and Lymphatic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0694550 BXGD009852 Recurrent pneumonia Infections; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0740385 BXGD009984 Aneurysm, Middle Cerebral Artery Nervous System Diseases; Cardiovascular Diseases
C0740386 BXGD009985 Aneurysm, Anterior Communicating Artery Nervous System Diseases; Cardiovascular Diseases
C0740387 BXGD009986 Aneurysm, Posterior Cerebral Artery Nervous System Diseases; Cardiovascular Diseases
C0747256 BXGD010168 Parasitic infection Pathological Conditions, Signs and Symptoms; Infections
C0751000 BXGD010281 Aneurysm, Anterior Cerebral Artery Nervous System Diseases; Cardiovascular Diseases
C0751001 BXGD010282 Aneurysm, Basilar Artery Nervous System Diseases; Cardiovascular Diseases
C0751002 BXGD010283 Aneurysm, Posterior Communicating Artery Nervous System Diseases; Cardiovascular Diseases
C0751003 BXGD010284 Brain Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0751004 BXGD010285 Giant Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0751005 BXGD010286 Mycotic Aneurysm, Intracranial Nervous System Diseases; Cardiovascular Diseases
C0852949 BXGD010957 Arteriopathic disease Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0860564 BXGD011231 Retinoic acid syndrome Pathological Conditions, Signs and Symptoms
C0917996 BXGD011425 Cerebral Aneurysm Nervous System Diseases; Cardiovascular Diseases
C1282952 BXGD012153 Enthesitis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Wounds and Injuries
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1333064 BXGD012587 Classical Hodgkin's Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1835686 BXGD014043 Recurrent bacterial skin infections
C1842774 BXGD014536 Hypermelanotic macule
C1844376 BXGD014627 Granulomatous Disease, Chronic, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C1844385 BXGD014630 Absence of bactericidal oxidative respiratory burst in phagocytes
C1844394 BXGD014632 Decreased activity of NADPH oxidase
C1846006 BXGD014771 Ectodermal dysplasia, hypohidrotic, with immune deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C1856251 BXGD015588 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C1861862 BXGD016084 Familial Hypertrophic Cardiomyopathy Type 4 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1862382 BXGD016125 SVEINSSON CHORIORETINAL ATROPHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1863999 BXGD016208 Peroxisome Biogenesis Disorder, Complementation Group D Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1879321 BXGD016572 Acute Myeloid Leukemia (AML-M2) Neoplasms
C1956089 BXGD016615 Osteophyte Musculoskeletal Diseases
C1960458 BXGD016662 Differentiation syndrome due to and following chemotherapy co-occurrent with acute promyelocytic leukemia Neoplasms
C1963165 BXGD016685 Malabsorption, CTCAE
C2242826 BXGD017006 Myeloblastic leukemia
C2347747 BXGD017040 Adult Classical Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2673462 BXGD017205 Recurrent Staphylococcus aureus infections
C2717865 BXGD017513 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Immune System Diseases; Cardiovascular Diseases
C2875014 BXGD017834 Acute disseminated encephalitis and encephalomyelitis (ADEM)
C2931299 BXGD018000 ZAP70 deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C3151409 BXGD018425 GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-POSITIVE, TYPE III
C3661525 BXGD019266 Autosomal Recessive Chronic Granulomatous Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C3714745 BXGD019427 Malabsorption Digestive System Diseases
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C4020969 BXGD020517 Inflammatory abnormality of the eye
C4021751 BXGD020756 Recurrent Klebsiella infections
C4021752 BXGD020757 Recurrent Aspergillus infections
C4025673 BXGD021724 Recurrent Burkholderia cepacia infections
C4025682 BXGD021731 Recurrent Serratia marcescens infections
C4049006 BXGD021912 Selective immunoglobulin A deficiency
C4049446 BXGD021933 Neointimal hyperplasia
C4529962 BXGD023178 Fatty Liver Disease
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0004275 Acetaldehyde 44.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein