protein

Showing entry for U4/U6 small nuclear ribonucleoprotein Prp31

General Target Information
BXGT Id	BXGT019006
Protein Name	U4/U6 small nuclear ribonucleoprotein Prp31
Uniport Id	Q8WWY3
Gene	PRPF31
Gene Id	26121
Domain	Nop; Prp31_C
Pfam	PF01798 PF09785
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
2. Genetic Information Processing	2.1 Transcription	hsa03040	Spliceosome

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0000398	mRNA splicing, via spliceosome
Biological Process	GO:0071166	ribonucleoprotein complex localization
Biological Process	GO:0000244	spliceosomal tri-snRNP complex assembly
molecular function	GO:0042802	identical protein binding
molecular function	GO:0043021	ribonucleoprotein complex binding
molecular function	GO:0003723	RNA binding
molecular function	GO:0070990	snRNP binding
molecular function	GO:0030622	U4atac snRNA binding
molecular function	GO:0030621	U4 snRNA binding
cellular component	GO:0015030	Cajal body
cellular component	GO:0071339	MLL1 complex
cellular component	GO:0016607	nuclear speck
cellular component	GO:0005654	nucleoplasm
cellular component	GO:0005634	nucleus
cellular component	GO:0071011	precatalytic spliceosome
cellular component	GO:0097526	spliceosomal tri-snRNP complex
cellular component	GO:0071005	U2-type precatalytic spliceosome
cellular component	GO:0005684	U2-type spliceosomal complex
cellular component	GO:0046540	U4/U6 x U5 tri-snRNP complex
cellular component	GO:0005690	U4atac snRNP
cellular component	GO:0005687	U4 snRNP

Reactome

Pathway Id	Pathway Name
R-HSA-72163	mRNA Splicing - Major Pathway
R-HSA-72172	mRNA Splicing
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854	Metabolism of RNA

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0003486	BXGD000197	Aortic Aneurysm	Cardiovascular Diseases
C0004238	BXGD000262	Atrial Fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005684	BXGD000319	Malignant neoplasm of urinary bladder	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695	BXGD000323	Bladder Neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007107	BXGD000428	Malignant neoplasm of larynx	Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0007134	BXGD000443	Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137	BXGD000445	Squamous cell carcinoma	Neoplasms
C0007847	BXGD000492	Malignant tumor of cervix	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013170	BXGD000802	Drug habituation	Chemically-Induced Disorders; Mental Disorders
C0015397	BXGD000983	Disorder of eye	Eye Diseases
C0017601	BXGD001125	Glaucoma	Eye Diseases
C0017638	BXGD001132	Glioma	Neoplasms
C0018777	BXGD001217	Conductive hearing loss	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784	BXGD001220	Sensorineural Hearing Loss (disorder)	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018818	BXGD001236	Ventricular Septal Defects	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019189	BXGD001298	Hepatitis, Chronic	Digestive System Diseases
C0020459	BXGD001394	Hyperinsulinism	Nutritional and Metabolic Diseases
C0020619	BXGD001447	Hypogonadism	Endocrine System Diseases
C0022578	BXGD001557	Keratoconus	Eye Diseases
C0023452	BXGD001651	Childhood Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467	BXGD001658	Leukemia, Myelocytic, Acute	Neoplasms
C0024437	BXGD001772	Macular degeneration	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0027022	BXGD001962	Myeloproliferative disease	Hemic and Lymphatic Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027819	BXGD002043	Neuroblastoma	Neoplasms
C0027831	BXGD002047	Neurofibromatosis 1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0028077	BXGD002069	Nyctalopia	Eye Diseases
C0028738	BXGD002081	Nystagmus	Eye Diseases; Nervous System Diseases
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028960	BXGD002101	Oligospermia	Male Urogenital Diseases
C0029089	BXGD002107	Ophthalmoplegia	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029124	BXGD002113	Optic Atrophy	Eye Diseases; Nervous System Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0029463	BXGD002160	Osteosarcoma	Neoplasms
C0030193	BXGD002191	Pain	Pathological Conditions, Signs and Symptoms
C0032460	BXGD002355	Polycystic Ovary Syndrome	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0035309	BXGD002530	Retinal Diseases	Eye Diseases
C0035333	BXGD002538	Retinitis	Eye Diseases
C0035334	BXGD002539	Retinitis Pigmentosa	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036421	BXGD002613	Systemic Scleroderma	Skin and Connective Tissue Diseases
C0037284	BXGD002679	Skin lesion	Skin and Connective Tissue Diseases
C0038013	BXGD002725	Ankylosing spondylitis	Musculoskeletal Diseases
C0040034	BXGD002836	Thrombocytopenia	Hemic and Lymphatic Diseases
C0040100	BXGD002840	Thymoma	Neoplasms; Hemic and Lymphatic Diseases
C0041296	BXGD002903	Tuberculosis	Infections
C0085207	BXGD003140	Gestational Diabetes	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085636	BXGD003218	Photophobia	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0086543	BXGD003294	Cataract	Eye Diseases
C0149782	BXGD003365	Squamous cell carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0151889	BXGD003498	Hyperreflexia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0153398	BXGD003631	Hypopharyngeal Cancer	Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0153676	BXGD003679	Secondary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0154860	BXGD003752	Hereditary retinal dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0158252	BXGD003877	Intervertebral disc disorder	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0175702	BXGD004008	Williams Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0175754	BXGD004015	Agenesis of corpus callosum	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0206062	BXGD004148	Lung Diseases, Interstitial	Respiratory Tract Diseases
C0206630	BXGD004195	Endometrial Stromal Sarcoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0220630	BXGD004302	Adult Liver Carcinoma	Digestive System Diseases; Neoplasms
C0220701	BXGD004325	RETINITIS PIGMENTOSA 1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0221023	BXGD004369	Cyclic neutropenia	Hemic and Lymphatic Diseases
C0221357	BXGD004449	Brachydactyly	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0234632	BXGD004691	Reduced visual acuity	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0235095	BXGD004723	Visual field constriction	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0235974	BXGD004796	Pancreatic carcinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238198	BXGD004893	Gastrointestinal Stromal Tumors	Digestive System Diseases; Neoplasms
C0238463	BXGD004938	Papillary thyroid carcinoma	Neoplasms; Endocrine System Diseases
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0242383	BXGD005160	Age related macular degeneration	Eye Diseases
C0266435	BXGD005668	Congenital hypoplasia of penis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0271051	BXGD006153	Macular retinal edema	Eye Diseases
C0278701	BXGD006566	Gastric Adenocarcinoma	Digestive System Diseases; Neoplasms
C0279000	BXGD006622	Liver and Intrahepatic Biliary Tract Carcinoma	Digestive System Diseases; Neoplasms
C0279068	BXGD006624	Childhood Solid Neoplasm
C0279702	BXGD006685	Conventional (Clear Cell) Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280099	BXGD006712	Adult Solid Neoplasm
C0280100	BXGD006713	Solid Neoplasm	Neoplasms
C0280321	BXGD006739	Squamous cell carcinoma of the hypopharynx
C0280324	BXGD006740	Laryngeal Squamous Cell Carcinoma	Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0302592	BXGD006851	Cervix carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0339525	BXGD007258	Autosomal dominant retinitis pigmentosa	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0345904	BXGD007745	Malignant neoplasm of liver	Digestive System Diseases; Neoplasms
C0346647	BXGD007832	Malignant neoplasm of pancreas	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0400966	BXGD008266	Non-alcoholic Fatty Liver Disease	Digestive System Diseases
C0456909	BXGD008883	Blindness	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397	BXGD008991	Electroretinogram abnormal
C0494165	BXGD009022	Secondary malignant neoplasm of liver	Digestive System Diseases; Neoplasms
C0585442	BXGD009593	Osteosarcoma of bone	Neoplasms
C0595989	BXGD009632	Carcinoma of larynx	Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0597645	BXGD009653	Viral Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0677886	BXGD009734	Epithelial ovarian cancer	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0686619	BXGD009835	Secondary malignant neoplasm of lymph node	Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0699885	BXGD009869	Carcinoma of bladder	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095	BXGD009875	Central neuroblastoma	Neoplasms; Nervous System Diseases
C0701807	BXGD009901	Acute anterior uveitis	Eye Diseases
C0795864	BXGD010754	Smith-Magenis syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0854723	BXGD011026	Retinal Dystrophies	Eye Diseases
C0919267	BXGD011426	ovarian neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680	BXGD011718	Malignant neoplasm of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955	BXGD012005	Tumor Cell Invasion
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1332986	BXGD012574	Childhood Osteosarcoma	Neoplasms
C1368404	BXGD012899	Hypopharyngeal Carcinoma	Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C1519176	BXGD013232	Salivary Gland Pleomorphic Adenoma	Neoplasms; Stomatognathic Diseases
C1519670	BXGD013241	Tumor Angiogenesis	Pathological Conditions, Signs and Symptoms
C1832378	BXGD013833	Retinitis Pigmentosa 18	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1832661	BXGD013866	ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1833929	BXGD013947	THYROID CARCINOMA, SPORADIC MEDULLARY
C1836926	BXGD014179	Bone spicule pigmentation of the retina
C1838601	BXGD014324	Retinitis Pigmentosa 11	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1838702	BXGD014339	Retinitis Pigmentosa 13	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1840077	BXGD014434	Anteverted nostril
C1842475	BXGD014520	Retinitis Pigmentosa 7	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1849367	BXGD015046	Nasal bridge wide
C1862475	BXGD016132	Abnormality of retinal pigmentation
C1867300	BXGD016446	RETINITIS PIGMENTOSA 9	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1963184	BXGD016688	Nystagmus, CTCAE 3.0
C1998028	BXGD016865	Photoreceptor degeneration	Eye Diseases
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2732473	BXGD017555	Ductal Carcinoma In Situ with Microinvasion
C3642347	BXGD019246	Basal-Like Breast Carcinoma
C3714756	BXGD019429	Intellectual Disability	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021786	BXGD020779	Atypical scarring of skin	Pathological Conditions, Signs and Symptoms
C4024818	BXGD021428	Progressive night blindness	Eye Diseases
C4048328	BXGD021903	cervical cancer	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4048329	BXGD021904	Immunosuppression
C4073099	BXGD022037	Perifoveal ring of hyperautofluorescence
C4086165	BXGD022126	Childhood Neuroblastoma	Neoplasms
C4551714	BXGD023398	Rod-Cone Dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036	BXGD023557	Nystagmus, CTCAE 5.0
C4721610	BXGD023760	Carcinoma, Ovarian Epithelial	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0002586	Calcium		40.08

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}