Showing entry for Insulin receptor-related protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008026
Protein NameInsulin receptor-related protein
Uniport IdP14616
GeneINSRR
Gene Id3645
DomainFurin-like; Pkinase_Tyr; Recep_L_domain
Pfam PF00757   PF07714   PF01030  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
6. Human Diseases 6.2 Cancers: Specific types hsa05215 Prostate cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031532 actin cytoskeleton reorganization
Biological Process GO:0048856 anatomical structure development
Biological Process GO:0071469 cellular response to alkaline pH
Biological Process GO:0030238 male sex determination
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0033674 positive regulation of kinase activity
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0005009 insulin-activated receptor activity
molecular function GO:0043560 insulin receptor substrate binding
molecular function GO:0043548 phosphatidylinositol 3-kinase binding
molecular function GO:0004714 transmembrane receptor protein tyrosine kinase activity
cellular component GO:0030424 axon
cellular component GO:0005899 insulin receptor complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001175 BXGD000029 Acquired Immunodeficiency Syndrome Infections; Immune System Diseases
C0001883 BXGD000086 Airway Obstruction Respiratory Tract Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003615 BXGD000212 Appendicitis Digestive System Diseases; Infections
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004610 BXGD000281 Bacteremia Pathological Conditions, Signs and Symptoms; Infections
C0004623 BXGD000282 Bacterial Infections Infections
C0004763 BXGD000289 Barrett Esophagus Digestive System Diseases; Neoplasms
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0008060 BXGD000516 child abuse behavior
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011311 BXGD000714 Dengue Fever Infections
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0014121 BXGD000895 Bacterial Endocarditis Infections; Cardiovascular Diseases
C0014236 BXGD000906 Endophthalmitis Infections; Eye Diseases
C0014583 BXGD000936 Episcleritis Eye Diseases
C0014743 BXGD000946 Erythema Nodosum Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0018081 BXGD001171 Gonorrhea Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0018378 BXGD001190 Guillain-Barre Syndrome Immune System Diseases; Nervous System Diseases
C0018572 BXGD001206 Hand, Foot and Mouth Disease Infections
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019045 BXGD001269 Hemoglobinopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019151 BXGD001290 Hepatic Encephalopathy Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022408 BXGD001544 Arthropathy Musculoskeletal Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023269 BXGD001627 leiomyosarcoma Neoplasms
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023891 BXGD001714 Liver Cirrhosis, Alcoholic Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Chemically-Induced Disorders
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024530 BXGD001783 Malaria Infections
C0024535 BXGD001785 Malaria, Falciparum Infections
C0024809 BXGD001808 Marijuana Abuse Chemically-Induced Disorders; Mental Disorders
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027497 BXGD001993 Nausea Pathological Conditions, Signs and Symptoms
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027609 BXGD002002 Neonatal Abstinence Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Chemically-Induced Disorders; Mental Disorders
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028756 BXGD002083 Obesity, Morbid Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030499 BXGD002232 Parasitic Diseases Infections
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033802 BXGD002425 Pseudogout Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0036117 BXGD002577 Salmonella infections Infections
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036416 BXGD002611 Scleritis Eye Diseases
C0038041 BXGD002732 Spotted Fever Group Rickettsiosis Infections
C0038363 BXGD002750 Aphthous Stomatitis Stomatognathic Diseases
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038586 BXGD002772 Substance Use Disorders Chemically-Induced Disorders; Mental Disorders
C0039147 BXGD002797 Syrinx formation
C0041296 BXGD002903 Tuberculosis Infections
C0042029 BXGD002951 Urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0043144 BXGD003032 Wheezing Pathological Conditions, Signs and Symptoms
C0085652 BXGD003224 Pyoderma Gangrenosum Skin and Connective Tissue Diseases
C0086103 BXGD003263 Decayed, Missing, and Filled Teeth
C0086692 BXGD003306 Benign Neoplasm Neoplasms
C0151332 BXGD003415 Active tuberculosis Infections
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0154084 BXGD003699 Stage 0 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0202239 BXGD004087 Uric acid measurement (procedure)
C0206729 BXGD004274 Neurofibrosarcoma Neoplasms; Nervous System Diseases
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220983 BXGD004350 Metabolic alkalosis Nutritional and Metabolic Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0238644 BXGD004949 Anemia, severe Hemic and Lymphatic Diseases
C0239981 BXGD005011 Hypoalbuminemia Hemic and Lymphatic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242510 BXGD005173 Drug usage Chemically-Induced Disorders; Mental Disorders
C0262655 BXGD005264 Recurrent urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0276289 BXGD006418 Zika Virus Infection Infections
C0278607 BXGD006548 Adult Leiomyosarcoma Neoplasms
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279986 BXGD006705 Childhood Leiomyosarcoma Neoplasms
C0339901 BXGD007289 Acute respiratory infections Infections; Respiratory Tract Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349534 BXGD007919 Carcinoma of anal margin Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392171 BXGD008033 Influenza-like symptoms
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0409651 BXGD008389 Seropositive rheumatoid arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0451641 BXGD008821 Urolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0520680 BXGD009102 Sleep Apnea, Central Respiratory Tract Diseases; Nervous System Diseases
C0521839 BXGD009183 Influenza-like illness Infections
C0524662 BXGD009238 Opiate Addiction Chemically-Induced Disorders; Mental Disorders
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0553730 BXGD009417 Calcium pyrophosphate deposition disease Musculoskeletal Diseases
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0585213 BXGD009587 Minor oral aphthous ulceration Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0687720 BXGD009844 Central Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740858 BXGD010012 Substance abuse problem Chemically-Induced Disorders; Mental Disorders
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0751783 BXGD010592 Lafora Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0872084 BXGD011319 Sarcopenia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0878773 BXGD011391 Overactive Bladder Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1135120 BXGD011689 Breakthrough Pain Pathological Conditions, Signs and Symptoms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1320214 BXGD012421 Invasive Streptococcus pneumoniae disease Infections
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1412036 BXGD013053 Anal squamous cell carcinoma Digestive System Diseases; Neoplasms
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1536220 BXGD013341 ST segment elevation myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1536221 BXGD013342 Non ST segment elevation myocardial infarction
C1541923 BXGD013355 Infective endocarditis Cardiovascular Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1561826 BXGD013364 Overweight and obesity
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1848934 BXGD014988 SPONDYLOCARPOTARSAL SYNOSTOSIS SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1855179 BXGD015468 CATARACT, ANTERIOR POLAR Eye Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2363741 BXGD017100 HIV-1 infection
C2936179 BXGD018103 Obesity, Visceral Nutritional and Metabolic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4316909 BXGD022713 Marijuana Use Mental Disorders; Behavior and Behavior Mechanisms
C4520821 BXGD023039 Stage 0 Breast Cancer AJCC v6 and v7 Neoplasms; Skin and Connective Tissue Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0012352 Chelerythrine 348.12
BXGC0024554 D-luciferin 280
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein