Showing entry for Pulmonary surfactant-associated protein D


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009804
Protein NamePulmonary surfactant-associated protein D
Uniport IdP35247
GeneSFTPD
Gene Id6441
DomainCollagen; Lectin_C; Surfac_D-trimer
Pfam PF01391   PF00059   PF09006  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0043152 induction of bacterial agglutination
Biological Process GO:0045087 innate immune response
Biological Process GO:0048286 lung alveolus development
Biological Process GO:0048246 macrophage chemotaxis
Biological Process GO:0052405 negative regulation by host of symbiont molecular function
Biological Process GO:0032703 negative regulation of interleukin-2 production
Biological Process GO:0042130 negative regulation of T cell proliferation
Biological Process GO:0050766 positive regulation of phagocytosis
Biological Process GO:0072593 reactive oxygen species metabolic process
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:1905226 regulation of adhesion of symbiont to host epithelial cell
Biological Process GO:0001817 regulation of cytokine production
Biological Process GO:0050776 regulation of immune response
Biological Process GO:0007585 respiratory gaseous exchange by respiratory system
Biological Process GO:0043129 surfactant homeostasis
Biological Process GO:0002224 toll-like receptor signaling pathway
molecular function GO:0030246 carbohydrate binding
molecular function GO:0042802 identical protein binding
cellular component GO:0045334 clathrin-coated endocytic vesicle
cellular component GO:0005581 collagen trimer
cellular component GO:0030139 endocytic vesicle
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005764 lysosome
cellular component GO:0005771 multivesicular body
cellular component GO:0005791 rough endoplasmic reticulum
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-1500931 Cell-Cell communication
R-HSA-1643685 Disease
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-392499 Metabolism of proteins
R-HSA-5668914 Diseases of metabolism
R-HSA-5683826 Surfactant metabolism
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-5687613 Diseases associated with surfactant metabolism
R-HSA-5688849 Defective CSF2RB causes SMDP5
R-HSA-5688890 Defective CSF2RA causes SMDP4
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001175 BXGD000029 Acquired Immunodeficiency Syndrome Infections; Immune System Diseases
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0003949 BXGD000242 Asbestosis Respiratory Tract Diseases; Occupational Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004626 BXGD000283 Pneumonia, Bacterial Infections; Respiratory Tract Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006267 BXGD000383 Bronchiectasis Respiratory Tract Diseases
C0006271 BXGD000384 Bronchiolitis Infections; Respiratory Tract Diseases
C0006272 BXGD000385 Bronchiolitis Obliterans Respiratory Tract Diseases
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0008677 BXGD000560 Bronchitis, Chronic Infections; Respiratory Tract Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010043 BXGD000644 Corneal Ulcer Infections; Eye Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013238 BXGD000806 Dry Eye Syndromes Eye Diseases
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019357 BXGD001326 Keratitis, Herpetic Infections; Eye Diseases
C0020192 BXGD001364 Hyaline Membrane Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020517 BXGD001415 Hypersensitivity Immune System Diseases
C0021313 BXGD001495 Infection of kidney Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022283 BXGD001533 Incontinentia Pigmenti Achromians Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0022408 BXGD001544 Arthropathy Musculoskeletal Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023529 BXGD001682 Leukomalacia, Periventricular Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023794 BXGD001700 Lipoidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0025303 BXGD001858 Meningococcal Infections Infections
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026272 BXGD001898 Mixed Connective Tissue Disease Skin and Connective Tissue Diseases
C0026918 BXGD001948 Mycobacterium Infections Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030409 BXGD002217 Paracoccidioidomycosis Infections
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033770 BXGD002417 Prune Belly Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034050 BXGD002452 Pulmonary Alveolar Proteinosis Respiratory Tract Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0034186 BXGD002469 Pyelonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035204 BXGD002511 Respiration Disorders Respiratory Tract Diseases
C0035220 BXGD002512 Respiratory Distress Syndrome, Newborn Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035235 BXGD002519 Respiratory Syncytial Virus Infections Infections
C0035242 BXGD002521 Respiratory Tract Diseases Respiratory Tract Diseases
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037090 BXGD002665 Signs and Symptoms, Respiratory Pathological Conditions, Signs and Symptoms
C0037116 BXGD002666 Silicosis Respiratory Tract Diseases; Occupational Diseases
C0038644 BXGD002776 Sudden infant death syndrome Pathological Conditions, Signs and Symptoms
C0041296 BXGD002903 Tuberculosis Infections
C0042029 BXGD002951 Urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085129 BXGD003128 Bronchial Hyperreactivity Respiratory Tract Diseases
C0085581 BXGD003192 Restrictive lung disease Respiratory Tract Diseases
C0149516 BXGD003324 Chronic sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0149825 BXGD003369 Hypertrophy of adenoids Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151449 BXGD003419 Primary Sjögren's syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0206061 BXGD004147 Pneumonia, Interstitial Respiratory Tract Diseases
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0206750 BXGD004287 Coronavirus Infections Infections
C0221019 BXGD004367 Sickle cell-beta-thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0234119 BXGD004622 Neuromuscular inhibition
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238013 BXGD004855 Invasive aspergillosis Infections
C0242231 BXGD005144 Coronary Stenosis Cardiovascular Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242488 BXGD005170 Acute Lung Injury Respiratory Tract Diseases
C0242706 BXGD005191 Hyperoxia Pathological Conditions, Signs and Symptoms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0262655 BXGD005264 Recurrent urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0264220 BXGD005375 Chronic disease of respiratory system Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0264490 BXGD005394 Acute respiratory failure Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Respiratory Tract Diseases
C0266929 BXGD005722 Chronic Periodontitis Stomatognathic Diseases
C0276653 BXGD006438 Invasive Pulmonary Aspergillosis Infections; Respiratory Tract Diseases
C0276655 BXGD006439 Infection by Aspergillus fumigatus Infections
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0282687 BXGD006826 Hemorrhagic Fever, Ebola Infections
C0314719 BXGD006890 Dryness of eye Eye Diseases
C0340044 BXGD007300 Acute exacerbation of chronic obstructive airways disease Respiratory Tract Diseases
C0342788 BXGD007552 Renal carnitine transport defect Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0476227 BXGD008981 pricking of skin
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0521585 BXGD009145 Gastrointestinal mucositis Digestive System Diseases; Stomatognathic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0600260 BXGD009701 Lung Diseases, Obstructive Respiratory Tract Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0694549 BXGD009851 Community acquired pneumonia Infections; Respiratory Tract Diseases
C0699949 BXGD009872 airway disease Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0741796 BXGD010041 Recurrent bronchitis Infections; Respiratory Tract Diseases
C0746102 BXGD010136 Chronic lung disease Respiratory Tract Diseases
C0748355 BXGD010195 Acute respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0751674 BXGD010547 Lymphangioleiomyomatosis Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0850666 BXGD010901 Infection caused by Helicobacter pylori Infections
C0852283 BXGD010939 Respiratory Distress Syndrome
C0857841 BXGD011160 Vaccinia virus infection
C0876973 BXGD011322 Infectious Lung Disorder Infections; Respiratory Tract Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C1112324 BXGD011662 Multifocal micronodular pneumocyte hyperplasia
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1262005 BXGD011860 Ischaemic cerebral infarction
C1262006 BXGD011861 Bacterial sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C1262020 BXGD011864 Diffuse alveolar damage
C1262091 BXGD011867 Lymphocytic infiltration
C1269955 BXGD012005 Tumor Cell Invasion
C1301700 BXGD012296 Cardiovascular morbidity
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306759 BXGD012374 Eosinophilic disorder Hemic and Lymphatic Diseases
C1320214 BXGD012421 Invasive Streptococcus pneumoniae disease Infections
C1527303 BXGD013265 Chronic Airflow Obstruction Respiratory Tract Diseases
C1535939 BXGD013323 Pneumocystis jiroveci pneumonia Infections; Respiratory Tract Diseases
C1701940 BXGD013526 Pneumonia, Ventilator-Associated Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1720830 BXGD013687 Painful Bladder Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1827192 BXGD013766 Allergic fungal sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C1855179 BXGD015468 CATARACT, ANTERIOR POLAR Eye Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2062441 BXGD016897 Influenza A
C2350236 BXGD017074 Idiopathic Interstitial Pneumonias Respiratory Tract Diseases
C2350344 BXGD017077 Chronic Lung Injury Respiratory Tract Diseases; Wounds and Injuries
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3203547 BXGD018566 Axial spondyloarthritis Musculoskeletal Diseases
C3536958 BXGD019077 Surfactant protein D measurement
C3539781 BXGD019086 Progressive cGVHD
C3665444 BXGD019288 Neutrophilia (disorder) Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C3711368 BXGD019378 Surfactant Dysfunction Respiratory Tract Diseases
C3714514 BXGD019409 Infection Infections
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3853540 BXGD019820 Aspirin exacerbated respiratory disease Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases; Immune System Diseases; Chemically-Induced Disorders; Otorhinolaryngologic Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3873302 BXGD019852 Secondary pulmonary alveolar proteinosis Respiratory Tract Diseases
C3899278 BXGD020078 Early Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C4025272 BXGD021615 Peripheral arterial stenosis
C4048329 BXGD021904 Immunosuppression
C4290046 BXGD022507 trachomatis
C4524268 BXGD023104 Advanced lung cancer
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0004738 Myo-Inositol 180.16
BXGC0005620 beta-D-Glucopyranose 180.16
BXGC0005625 alpha-D-Glucopyranose 180.16
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0037697 Methyl Alpha-D-Mannoside 194.08
BXGC0038164 D-Mannose 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein