Showing entry for Gamma-aminobutyric acid type B receptor subunit 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005161
Protein NameGamma-aminobutyric acid type B receptor subunit 2
Uniport IdO75899
GeneGABBR2
Gene Id9568
Domain7tm_3; ANF_receptor; GBR2_CC
Pfam PF00003   PF01094   PF18455  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
5. Organismal Systems 5.7 Sensory system hsa04742 Taste transduction
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0007214 gamma-aminobutyric acid signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007194 negative regulation of adenylate cyclase activity
Biological Process GO:0150099 neuron-glial cell signaling
molecular function GO:0004965 G protein-coupled GABA receptor activity
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0004888 transmembrane signaling receptor activity
cellular component GO:0005737 cytoplasm
cellular component GO:1902710 GABA receptor complex
cellular component GO:0038039 G protein-coupled receptor heterodimeric complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-1296059 G protein gated Potassium channels
R-HSA-1296065 Inwardly rectifying K+ channels
R-HSA-1296071 Potassium Channels
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-500792 GPCR ligand binding
R-HSA-977443 GABA receptor activation
R-HSA-977444 GABA B receptor activation
R-HSA-991365 Activation of GABAB receptors
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0006325 BXGD000393 Bruxism Stomatognathic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0013132 BXGD000799 Drooling Stomatognathic Diseases
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0020071 BXGD001356 Hereditary Sensory Autonomic Neuropathy, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020578 BXGD001434 Hyperventilation Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0024433 BXGD001771 Macrostomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0085271 BXGD003148 Self-Injurious Behavior Behavior and Behavior Mechanisms
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0155789 BXGD003822 Bleeding esophageal varices Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0202252 BXGD004089 VITAMIN B12 MEASUREMENT
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0265780 BXGD005574 Congenital absence of lung Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0392525 BXGD008052 Nephrolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0409348 BXGD008384 Flexion contracture of proximal interphalangeal joint
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0423867 BXGD008517 Fine hair
C0426421 BXGD008561 Wide nose
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0575802 BXGD009521 Small hand
C0576226 BXGD009527 Short foot
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0858600 BXGD011182 Taste sweet
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1834055 BXGD013953 Underdeveloped nasal alae
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836543 BXGD014130 Thick vermilion border
C1836830 BXGD014165 Developmental regression Mental Disorders
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1848673 BXGD014963 Hypoplastic feet
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1861063 BXGD016011 TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)
C1865014 BXGD016282 Long philtrum
C1963060 BXGD016679 Agitation, CTCAE 3.0
C2242817 BXGD017005 Homocysteine measurement
C2609266 BXGD017174 Gastroesophageal varices Digestive System Diseases
C2748910 BXGD017609 Rett Syndrome, Atypical Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3279222 BXGD018751 Aplasia/Hypoplasia of the cerebellum
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3894553 BXGD020038 response to simvastatin
C4021785 BXGD020778 Abnormality of the metacarpal bones Musculoskeletal Diseases
C4024167 BXGD021295 Abnormality of the antitragus
C4551583 BXGD023361 Cerebral cortical atrophy
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552855 BXGD023528 Agitation, CTCAE 5.0
C4553743 BXGD023548 Spasticity, CTCAE
C4693546 BXGD023604 NEURODEVELOPMENTAL DISORDER WITH POOR LANGUAGE AND LOSS OF HAND SKILLS
C4693550 BXGD023605 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 59
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004587 (E)-3-Phenyl-2-propenal 132.16
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0038316 Cholesterol 386.35
BXGC0039350 Gs-39783 337.16
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein