Showing entry for Progonadoliberin-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005739
Protein NameProgonadoliberin-1
Uniport IdP01148
GeneGNRH1
Gene Id2796
DomainGnRH
Pfam PF00446  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.2 Endocrine system hsa04912 GnRH signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0044849 estrous cycle
Biological Process GO:0007565 female pregnancy
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0030238 male sex determination
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0033087 negative regulation of immature T cell proliferation
Biological Process GO:2001223 negative regulation of neuron migration
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:2000354 regulation of ovarian follicle development
Biological Process GO:0000003 reproduction
Biological Process GO:0031960 response to corticosteroid
Biological Process GO:0045471 response to ethanol
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0035864 response to potassium ion
Biological Process GO:1990637 response to prolactin
Biological Process GO:0034695 response to prostaglandin E
Biological Process GO:0033574 response to testosterone
Biological Process GO:0007165 signal transduction
molecular function GO:0005183 gonadotropin hormone-releasing hormone activity
molecular function GO:0031530 gonadotropin-releasing hormone receptor binding
molecular function GO:0005179 hormone activity
cellular component GO:0043679 axon terminus
cellular component GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
cellular component GO:0030425 dendrite
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005798 Golgi-associated vesicle
cellular component GO:0005739 mitochondrion
cellular component GO:1990008 neurosecretory vesicle
cellular component GO:0043204 perikaryon
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375281 Hormone ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-500792 GPCR ligand binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001624 BXGD000067 Adrenal Gland Neoplasms Neoplasms; Endocrine System Diseases
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0003126 BXGD000180 Anosmia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013338 BXGD000816 Pituitary dwarfism Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0014173 BXGD000903 Endometrial Hyperplasia Female Urogenital Diseases and Pregnancy Complications
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018418 BXGD001192 Gynecomastia Skin and Connective Tissue Diseases
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018995 BXGD001265 Hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020514 BXGD001414 Hyperprolactinemia Nervous System Diseases; Endocrine System Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0020635 BXGD001455 Hypopituitarism Nervous System Diseases; Endocrine System Diseases
C0020672 BXGD001461 Hypothermia, natural Pathological Conditions, Signs and Symptoms
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022650 BXGD001568 Kidney Calculi Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022735 BXGD001581 Klinefelter Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024003 BXGD001726 Lordosis Musculoskeletal Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0025319 BXGD001862 Menopausal syndrome Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028838 BXGD002088 Ocular Headache Pathological Conditions, Signs and Symptoms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0032002 BXGD002320 Pituitary Diseases Nervous System Diseases; Endocrine System Diseases
C0034012 BXGD002449 Delayed Puberty Endocrine System Diseases
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0039231 BXGD002799 Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0080203 BXGD003108 Tachyarrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151449 BXGD003419 Primary Sjögren's syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0151721 BXGD003465 Testicular hypogonadism Endocrine System Diseases
C0162809 BXGD003981 Kallmann Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0162830 BXGD003987 Dermatitis, Phototoxic Skin and Connective Tissue Diseases
C0206141 BXGD004160 Idiopathic Hypereosinophilic Syndrome Hemic and Lymphatic Diseases
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0220748 BXGD004336 Cartilage-hair hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Musculoskeletal Diseases; Immune System Diseases
C0221369 BXGD004453 Acquired Camptodactyly
C0221405 BXGD004458 Pituitary cachexia Nervous System Diseases; Endocrine System Diseases
C0232939 BXGD004568 Primary physiologic amenorrhea Pathological Conditions, Signs and Symptoms
C0232940 BXGD004569 Secondary physiologic amenorrhea Pathological Conditions, Signs and Symptoms
C0241011 BXGD005073 Low serum estradiol levels
C0241355 BXGD005092 Small testicle
C0242342 BXGD005152 Sheehan Syndrome Nervous System Diseases; Endocrine System Diseases
C0242343 BXGD005153 Panhypopituitarism Nervous System Diseases; Endocrine System Diseases
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0262444 BXGD005244 Abnormality of the dentition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0266013 BXGD005606 Congenital hypoplasia of breast Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266399 BXGD005663 Infantile uterus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0268287 BXGD005884 Deficiency of steroid 21-monooxygenase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0270749 BXGD006098 Marie Cerebellar Ataxia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0271527 BXGD006208 Cryptogenic sexual precocity Endocrine System Diseases
C0271577 BXGD006215 Isolated gonadotropin deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0271578 BXGD006216 Female hypogonadism syndrome Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases; Endocrine System Diseases
C0271582 BXGD006217 Isolated lutropin deficiency (disorder) Endocrine System Diseases
C0271623 BXGD006222 Hypogonadotropic hypogonadism Endocrine System Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0342381 BXGD007469 Idiopathic growth hormone deficiency
C0342384 BXGD007470 Idiopathic hypogonadotropic hypogonadism Endocrine System Diseases
C0342543 BXGD007500 Central Precocious Puberty Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392514 BXGD008051 Hereditary hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0392525 BXGD008052 Nephrolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0423618 BXGD008490 Throbbing Headache Pathological Conditions, Signs and Symptoms
C0423623 BXGD008491 Bilateral Headache Pathological Conditions, Signs and Symptoms
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0425957 BXGD008555 Secondary amenorrhea Pathological Conditions, Signs and Symptoms
C0428977 BXGD008644 Bradycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0474366 BXGD008949 Generalized Headache Pathological Conditions, Signs and Symptoms
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0541764 BXGD009259 Delayed bone age
C0574785 BXGD009506 Lower Urinary Tract Symptoms Pathological Conditions, Signs and Symptoms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0685409 BXGD009810 Congenital Camptodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0685840 BXGD009821 Congenital hypoplasia of ovary Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0747102 BXGD010159 Ovarian failure Endocrine System Diseases
C0750887 BXGD010240 Adrenal Cancer Neoplasms; Endocrine System Diseases
C0751186 BXGD010339 Orthostatic Headache Pathological Conditions, Signs and Symptoms
C0751187 BXGD010340 Periorbital Headache Pathological Conditions, Signs and Symptoms
C0751189 BXGD010341 Retro-Ocular Headache Pathological Conditions, Signs and Symptoms
C0751190 BXGD010342 Sharp Headache Pathological Conditions, Signs and Symptoms
C0751192 BXGD010343 Vertex Headache Pathological Conditions, Signs and Symptoms
C0751230 BXGD010360 Hypothalamic Dysfunction Syndromes Nervous System Diseases
C0848255 BXGD010876 female puberty
C0848332 BXGD010879 Spots on skin Skin and Connective Tissue Diseases
C0848676 BXGD010883 Subfertility, Male Male Urogenital Diseases
C0852654 BXGD010947 21-hydroxylase deficiency
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0877781 BXGD011358 Hemicrania Pathological Conditions, Signs and Symptoms
C0917731 BXGD011407 Male sterility Male Urogenital Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C0948896 BXGD011563 Primary hypogonadism Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1301700 BXGD012296 Cardiovascular morbidity
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1384514 BXGD012940 Conn Syndrome Endocrine System Diseases
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1504412 BXGD013143 Testotoxicosis Endocrine System Diseases
C1514428 BXGD013203 Primary peritoneal carcinoma Digestive System Diseases; Neoplasms
C1527358 BXGD013279 Phototoxicity Skin and Connective Tissue Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1629609 BXGD013479 Age at menopause
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1739363 BXGD013734 Prostatic Hypertrophy Male Urogenital Diseases
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C1827524 BXGD013773 Wide spaced nipples
C1836308 BXGD014107 Generalized joint laxity
C1836542 BXGD014129 Depressed nasal bridge
C1840311 BXGD014445 Laryngeal cleft Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1846228 BXGD014793 Absence of pubertal development
C1853926 BXGD015365 NONAKA MYOPATHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1856897 BXGD015653 Eunuchoidism, familial hypogonadotropic Endocrine System Diseases
C1858573 BXGD015809 Sparse pubic hair
C1858574 BXGD015810 Sparse axillary hair
C1859305 BXGD015870 Cerebellar Ataxia and Hypogonadotropic Hypogonadism Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Endocrine System Diseases
C1859391 BXGD015884 Absent pubic hair
C1862863 BXGD016138 Sparse body hair
C1865866 BXGD016345 Congenital sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C2364082 BXGD017123 Sense of smell impaired Nervous System Diseases
C2874188 BXGD017826 Isolated deficiency of pituitary hormone
C2874189 BXGD017827 Necrosis of pituitary gland (postpartum)
C2874190 BXGD017828 Pituitary short stature
C2936858 BXGD018147 Congenital adrenal hyperplasia due to 21 hydroxylase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3469186 BXGD018909 HEMOCHROMATOSIS, TYPE 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3489396 BXGD018929 Hypogonadism, Isolated Hypogonadotropic Endocrine System Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714796 BXGD019434 Isolated somatotropin deficiency
C3899503 BXGD020084 Congenital hypogonadotropic hypogonadism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C4021107 BXGD020557 Non-obstructive azoospermia Male Urogenital Diseases
C4021551 BXGD020667 Absence of secondary sex characteristics
C4021776 BXGD020772 Abnormality of the voice
C4022675 BXGD020952 Increased female libido
C4025569 BXGD021668 Eunuchoid habitus Pathological Conditions, Signs and Symptoms
C4025886 BXGD021846 Severe periodontitis Stomatognathic Diseases
C4025901 BXGD021856 Abnormality of body height
C4072887 BXGD022011 Decreased circulating gonadotropin level
C4073137 BXGD022045 Decreased serum testosterone level
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4552011 BXGD023477 Gonadotropin deficiency
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0019091 D-Tryptophan 204.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein