Showing entry for Integrin alpha-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008299
Protein NameIntegrin alpha-2
Uniport IdP17301
GeneITGA2
Gene Id3673
DomainFG-GAP; Integrin_alpha2; VWA
Pfam PF01839   PF08441   PF00092  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04512 ECM-receptor interaction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.1 Immune system hsa04640 Hematopoietic cell lineage
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05222 Small cell lung cancer
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009887 animal organ morphogenesis
Biological Process GO:0007596 blood coagulation
Biological Process GO:0007155 cell adhesion
Biological Process GO:0033627 cell adhesion mediated by integrin
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0031589 cell-substrate adhesion
Biological Process GO:0071392 cellular response to estradiol stimulus
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0038065 collagen-activated signaling pathway
Biological Process GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
Biological Process GO:0045184 establishment of protein localization
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0007565 female pregnancy
Biological Process GO:0048041 focal adhesion assembly
Biological Process GO:0070365 hepatocyte differentiation
Biological Process GO:0006971 hypotonic response
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0030879 mammary gland development
Biological Process GO:0048333 mesodermal cell differentiation
Biological Process GO:0010694 positive regulation of alkaline phosphatase activity
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:0031346 positive regulation of cell projection organization
Biological Process GO:0033343 positive regulation of collagen binding
Biological Process GO:0032967 positive regulation of collagen biosynthetic process
Biological Process GO:0043388 positive regulation of DNA binding
Biological Process GO:0010634 positive regulation of epithelial cell migration
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0002687 positive regulation of leukocyte migration
Biological Process GO:0060100 positive regulation of phagocytosis, engulfment
Biological Process GO:0050927 positive regulation of positive chemotaxis
Biological Process GO:0014911 positive regulation of smooth muscle cell migration
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:0045987 positive regulation of smooth muscle contraction
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:0051971 positive regulation of transmission of nerve impulse
Biological Process GO:0014075 response to amine
Biological Process GO:0042493 response to drug
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0033591 response to L-ascorbic acid
Biological Process GO:0014850 response to muscle activity
Biological Process GO:0071107 response to parathyroid hormone
Biological Process GO:0043589 skin morphogenesis
Biological Process GO:0006929 substrate-dependent cell migration
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0005518 collagen binding
molecular function GO:0098639 collagen binding involved in cell-matrix adhesion
molecular function GO:0038064 collagen receptor activity
molecular function GO:0043395 heparan sulfate proteoglycan binding
molecular function GO:0005178 integrin binding
molecular function GO:0043236 laminin binding
molecular function GO:0046872 metal ion binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0001618 virus receptor activity
cellular component GO:0043679 axon terminus
cellular component GO:0045178 basal part of cell
cellular component GO:0009986 cell surface
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005925 focal adhesion
cellular component GO:0034666 integrin alpha2-beta1 complex
cellular component GO:0008305 integrin complex
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1266738 Developmental Biology
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474244 Extracellular matrix organization
R-HSA-162582 Signal Transduction
R-HSA-216083 Integrin cell surface interactions
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000157 Laminin interactions
R-HSA-3000157 Laminin interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-373760 L1CAM interactions
R-HSA-422475 Axon guidance
R-HSA-447041 CHL1 interactions
R-HSA-6806834 Signaling by MET
R-HSA-75892 Platelet Adhesion to exposed collagen
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8875878 MET promotes cell motility
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002448 BXGD000115 Ameloblastoma Neoplasms
C0002965 BXGD000162 Angina, Unstable Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003869 BXGD000234 Arthritis, Infectious Infections; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0005129 BXGD000304 Bernard-Soulier Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007722 BXGD000474 Cephalhematoma due to birth trauma Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Wounds and Injuries
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010072 BXGD000649 Coronary Thrombosis Cardiovascular Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013491 BXGD000847 Ecchymosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025222 BXGD001838 Melena Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0026640 BXGD001912 Mouth Neoplasms Neoplasms; Stomatognathic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029443 BXGD002152 Osteomyelitis Infections; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030499 BXGD002232 Parasitic Diseases Infections
C0032051 BXGD002326 Placental Insufficiency Female Urogenital Diseases and Pregnancy Complications
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035328 BXGD002537 Retinal Vein Occlusion Eye Diseases; Cardiovascular Diseases
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0035439 BXGD002551 Rheumatic Heart Disease Infections; Cardiovascular Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0040015 BXGD002833 Thrombasthenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0042974 BXGD003019 von Willebrand Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0085697 BXGD003245 Chronic pyelonephritis Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0155094 BXGD003769 Corneal pannus Pathological Conditions, Signs and Symptoms; Eye Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202236 BXGD004086 Triglycerides measurement
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0241144 BXGD005080 Petechiae of skin Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0333307 BXGD006946 Superficial ulcer Pathological Conditions, Signs and Symptoms
C0338106 BXGD007167 Adenocarcinoma of colon Digestive System Diseases; Neoplasms
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0452138 BXGD008831 Sensorineural hearing loss, bilateral Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0458247 BXGD008904 Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0557874 BXGD009444 Global developmental delay
C0577631 BXGD009535 Carotid Atherosclerosis Nervous System Diseases; Cardiovascular Diseases
C0584960 BXGD009579 Factor V Leiden mutation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0684337 BXGD009796 Ewings sarcoma-primitive neuroectodermal tumor (PNET) Neoplasms
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0741250 BXGD010028 aspirin sensitivity
C0751211 BXGD010350 Hyperalgesia, Primary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751212 BXGD010351 Hyperalgesia, Secondary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751213 BXGD010352 Tactile Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0856825 BXGD011118 Acute GVH disease Immune System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948201 BXGD011515 Alloimmunisation
C1135868 BXGD011700 Gestational Trophoblastic Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1264031 BXGD011908 Alloimmune thrombocytopenia
C1264039 BXGD011909 von Willebrand Disease, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1277187 BXGD012109 Left ventricular systolic dysfunction Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1397307 BXGD012996 Cardiac fibrosis
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1527411 BXGD013292 Thrombosis of retinal vein Eye Diseases; Cardiovascular Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1692886 BXGD013495 Arthritis, Bacterial Infections; Musculoskeletal Diseases
C1697453 BXGD013507 Spontaneous hematomas
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1963943 BXGD016706 Atherothrombosis
C2237512 BXGD016961 cephalohematoma
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2348101 BXGD017053 Destructive Arthritis Musculoskeletal Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3280114 BXGD018804 Glycoprotein IA Deficiency Hemic and Lymphatic Diseases
C3853779 BXGD019822 Neonatal Alloimmune Thrombocytopenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C3854603 BXGD019839 FNAITP
C3887524 BXGD019892 Skin Erosion Skin and Connective Tissue Diseases
C3887640 BXGD019908 Astrocytosis Pathological Conditions, Signs and Symptoms
C3887641 BXGD019909 Recurrent hepatitis Digestive System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4087504 BXGD022156 Peritoneal dissemination
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721779 BXGD023769 Ovarian cancer stage IV
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0002708 Strontium 87.62
BXGC0003705 Chloride 35.45
BXGC0049042 Anhydromaggiemycin 408.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein