Showing entry for Potassium-transporting ATPase alpha chain 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011068
Protein NamePotassium-transporting ATPase alpha chain 2
Uniport IdP54707
GeneATP12A
Gene Id479
DomainCation_ATPase; Cation_ATPase_C; Cation_ATPase_N; E1-E2_ATPase; Hydrolase
Pfam PF00689   PF00690  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.2 Energy metabolism hsa00190 Oxidative phosphorylation
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030007 cellular potassium ion homeostasis
Biological Process GO:0006883 cellular sodium ion homeostasis
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:1902600 proton transmembrane transport
Biological Process GO:0006885 regulation of pH
Biological Process GO:0036376 sodium ion export across plasma membrane
molecular function GO:0005524 ATP binding
molecular function GO:0046872 metal ion binding
molecular function GO:0008900 potassium:proton exchanging ATPase activity
molecular function GO:0005391 sodium:potassium-exchanging ATPase activity
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0005889 potassium:proton exchanging ATPase complex
Reactome
Pathway Id Pathway Name
R-HSA-382551 Transport of small molecules
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001883 BXGD000086 Airway Obstruction Respiratory Tract Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0004763 BXGD000289 Barrett Esophagus Digestive System Diseases; Neoplasms
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013295 BXGD000812 Duodenal Ulcer Digestive System Diseases
C0013395 BXGD000831 Dyspepsia Pathological Conditions, Signs and Symptoms
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0014868 BXGD000965 Esophagitis Digestive System Diseases
C0014869 BXGD000966 Peptic Esophagitis Digestive System Diseases
C0017150 BXGD001095 Gastrinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0017152 BXGD001096 Gastritis Digestive System Diseases
C0017160 BXGD001099 Gastroenteritis Digestive System Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0017178 BXGD001102 Gastrointestinal Diseases Digestive System Diseases
C0018834 BXGD001238 Heartburn Pathological Conditions, Signs and Symptoms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020598 BXGD001440 Hypocalcemia Nutritional and Metabolic Diseases
C0022650 BXGD001568 Kidney Calculi Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023051 BXGD001602 Laryngeal Diseases Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024473 BXGD001778 Magnesium Deficiency Nutritional and Metabolic Diseases
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030920 BXGD002263 Peptic Ulcer Digestive System Diseases
C0035204 BXGD002511 Respiration Disorders Respiratory Tract Diseases
C0040479 BXGD002870 Torsades de Pointes Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0151723 BXGD003466 Hypomagnesemia Nutritional and Metabolic Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162316 BXGD003936 Iron deficiency anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0239295 BXGD004976 Candidiasis of the esophagus Digestive System Diseases; Infections
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0267055 BXGD005729 Erosive esophagitis Digestive System Diseases
C0275551 BXGD006379 Primary bacterial peritonitis Digestive System Diseases; Infections
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0333291 BXGD006941 Bleeding ulcer Pathological Conditions, Signs and Symptoms
C0333294 BXGD006943 Recurrent ulcer Pathological Conditions, Signs and Symptoms
C0333983 BXGD006975 Hyperplastic Polyp Pathological Conditions, Signs and Symptoms
C0341106 BXGD007389 Eosinophilic esophagitis Digestive System Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0343386 BXGD007620 Clostridium difficile infection Infections
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0392525 BXGD008052 Nephrolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0400821 BXGD008257 Colitis, Microscopic Digestive System Diseases
C0428883 BXGD008639 Diastolic blood pressure
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0559031 BXGD009464 Functional Gastrointestinal Disorders Digestive System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677659 BXGD009724 Gastro-esophageal reflux disease with esophagitis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0687720 BXGD009844 Central Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699949 BXGD009872 airway disease Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0850666 BXGD010901 Infection caused by Helicobacter pylori Infections
C0871470 BXGD011316 Systolic Pressure
C0949083 BXGD011569 Hospital acquired pneumonia Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases
C1168250 BXGD011784 Laryngopharyngeal Reflux Digestive System Diseases; Respiratory Tract Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306759 BXGD012374 Eosinophilic disorder Hemic and Lymphatic Diseases
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1514284 BXGD013201 Potassium Deficiency Disorder Nutritional and Metabolic Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1701940 BXGD013526 Pneumonia, Ventilator-Associated Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C2004489 BXGD016873 Regurgitation
C2242528 BXGD016976 Non-erosive reflux disease
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2939175 BXGD018175 Meconium ileus Digestive System Diseases
C3854460 BXGD019837 Atrio-oesophageal fistula Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C3887639 BXGD019907 Autoimmune gastritis Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0039507 Digitoxigenin 374.25
BXGC0051524 Ouabain 584.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein