Showing entry for Dynamin-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012810
Protein NameDynamin-1
Uniport IdQ05193
GeneDNM1
Gene Id1759
DomainDynamin_M; Dynamin_N; GED; PH
Pfam PF01031   PF00350   PF02212   PF00169  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
5. Organismal Systems 5.6 Nervous system hsa04721 Synaptic vesicle cycle
5. Organismal Systems 5.5 Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05100 Bacterial invasion of epithelial cells
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0003374 dynamin family protein polymerization involved in mitochondrial fission
Biological Process GO:0006897 endocytosis
Biological Process GO:0007032 endosome organization
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0002031 G protein-coupled receptor internalization
Biological Process GO:0061025 membrane fusion
Biological Process GO:0000266 mitochondrial fission
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0048285 organelle fission
Biological Process GO:1900244 positive regulation of synaptic vesicle endocytosis
Biological Process GO:0098884 postsynaptic neurotransmitter receptor internalization
Biological Process GO:0031623 receptor internalization
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0050803 regulation of synapse structure or activity
Biological Process GO:1904645 response to amyloid-beta
Biological Process GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane
Biological Process GO:1901998 toxin transport
molecular function GO:0031749 D2 dopamine receptor binding
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0008017 microtubule binding
molecular function GO:0050998 nitric-oxide synthase binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0003723 RNA binding
molecular function GO:0017124 SH3 domain binding
cellular component GO:0030424 axon
cellular component GO:0005737 cytoplasm
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0043197 dendritic spine
cellular component GO:0044327 dendritic spine head
cellular component GO:0070062 extracellular exosome
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016020 membrane
cellular component GO:0030117 membrane coat
cellular component GO:0005874 microtubule
cellular component GO:0015630 microtubule cytoskeleton
cellular component GO:0031966 mitochondrial membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0001917 photoreceptor inner segment
cellular component GO:0098684 photoreceptor ribbon synapse
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0098844 postsynaptic endocytic zone membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0098835 presynaptic endocytic zone membrane
cellular component GO:0045202 synapse
cellular component GO:0008021 synaptic vesicle
cellular component GO:0043196 varicosity
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1280218 Adaptive Immune System
R-HSA-157858 Gap junction trafficking and regulation
R-HSA-162582 Signal Transduction
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166520 Signaling by NTRKs
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-190828 Gap junction trafficking
R-HSA-190873 Gap junction degradation
R-HSA-196025 Formation of annular gap junctions
R-HSA-199991 Membrane Trafficking
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-373760 L1CAM interactions
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-422475 Axon guidance
R-HSA-437239 Recycling pathway of L1
R-HSA-5653656 Vesicle-mediated transport
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000921 BXGD000019 Accidental Falls
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0020608 BXGD001443 Hypodontia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027960 BXGD002062 Nevus Neoplasms
C0027962 BXGD002064 Melanocytic nevus Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0031212 BXGD002295 Personality Disorders Mental Disorders
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0035369 BXGD002543 Retroviridae Infections Infections
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0086237 BXGD003273 Epilepsy, Cryptogenic Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235659 BXGD004763 Reduced fetal movement Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0236018 BXGD004804 Aura Nervous System Diseases
C0238111 BXGD004877 Lennox-Gastaut syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0239676 BXGD004989 High forehead
C0241210 BXGD005086 Speech Delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0341106 BXGD007389 Eosinophilic esophagitis Digestive System Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0349588 BXGD007933 Short stature
C0393706 BXGD008126 Early infantile epileptic encephalopathy with suppression bursts Nervous System Diseases
C0423110 BXGD008471 Downward slant of palpebral fissure
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0432072 BXGD008718 Dysmorphic features
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0595948 BXGD009630 Atypical absence seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0748607 BXGD010201 Recurrent seizure Nervous System Diseases
C0751111 BXGD010319 Awakening Epilepsy Nervous System Diseases
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1314691 BXGD012388 Age at menarche Behavior and Behavior Mechanisms
C1456781 BXGD013123 Benign melanocytic nevus Neoplasms
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836508 BXGD014124 Generalized tonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1838391 BXGD014313 Limb hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1842581 BXGD014525 Abnormal corpus callosum morphology Pathological Conditions, Signs and Symptoms
C1850601 BXGD015159 Abnormality of brainstem morphology
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1857704 BXGD015741 Abnormal myelination
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1865349 BXGD016317 Ethylmalonic encephalopathy Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2243051 BXGD017008 Large head (disorder)
C2919142 BXGD017867 Short Stature, CTCAE
C3463992 BXGD018904 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1 Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887898 BXGD019926 Infantile Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021759 BXGD020762 Generalized myoclonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4023479 BXGD021200 EEG with focal sharp slow waves
C4023687 BXGD021243 EEG with multifocal slow activity
C4025846 BXGD021826 Abnormality of vision
C4225357 BXGD022236 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 31
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4552072 BXGD023482 X-linked infantile spasms Nervous System Diseases
C4553743 BXGD023548 Spasticity, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002144 Tetradecanoic acid 228.37
BXGC0002588 Magnesium 24.31
BXGC0005422 Dicaffeoylputrescine 412.44
BXGC0042103 Tetradecylamine 213.25
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein