Showing entry for Potassium voltage-gated channel subfamily A member 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013037
Protein NamePotassium voltage-gated channel subfamily A member 1
Uniport IdQ09470
GeneKCNA1
Gene Id3736
DomainBTB_2; Ion_trans
Pfam PF02214   PF00520  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0010644 cell communication by electrical coupling
Biological Process GO:0034613 cellular protein localization
Biological Process GO:0071286 cellular response to magnesium ion
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
Biological Process GO:0050976 detection of mechanical stimulus involved in sensory perception of touch
Biological Process GO:0021766 hippocampus development
Biological Process GO:0010960 magnesium ion homeostasis
Biological Process GO:0007405 neuroblast proliferation
Biological Process GO:0050905 neuromuscular process
Biological Process GO:0019228 neuronal action potential
Biological Process GO:0023041 neuronal signal transduction
Biological Process GO:1903818 positive regulation of voltage-gated potassium channel activity
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0006813 potassium ion transport
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0006937 regulation of muscle contraction
Biological Process GO:0001964 startle response
molecular function GO:0005251 delayed rectifier potassium channel activity
molecular function GO:0097718 disordered domain specific binding
molecular function GO:0005267 potassium channel activity
molecular function GO:0015079 potassium ion transmembrane transporter activity
molecular function GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
molecular function GO:0099508 voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
molecular function GO:0005249 voltage-gated potassium channel activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0043679 axon terminus
cellular component GO:0030054 cell junction
cellular component GO:0009986 cell surface
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0044224 juxtaparanode region of axon
cellular component GO:0043025 neuronal cell body
cellular component GO:0033270 paranode region of axon
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
cellular component GO:0042734 presynaptic membrane
cellular component GO:0045202 synapse
cellular component GO:0008076 voltage-gated potassium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-1296071 Potassium Channels
R-HSA-1296072 Voltage gated Potassium channels
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004158 BXGD000261 Athetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007384 BXGD000463 Cataplexy Nervous System Diseases; Mental Disorders
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007760 BXGD000476 Cerebellar Diseases Nervous System Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0012569 BXGD000777 Diplopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013405 BXGD000834 Dyspnea, Paroxysmal Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Cardiovascular Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0018564 BXGD001204 Hand deformities Musculoskeletal Diseases
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0024591 BXGD001789 Malignant hyperpyrexia due to anesthesia Pathological Conditions, Signs and Symptoms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027125 BXGD001975 Myotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027497 BXGD001993 Nausea Pathological Conditions, Signs and Symptoms
C0027854 BXGD002050 Neurologic Manifestations Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0034935 BXGD002497 Babinski Reflex
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041960 BXGD002943 Ureterocele Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0085271 BXGD003148 Self-Injurious Behavior Behavior and Behavior Mechanisms
C0085583 BXGD003194 Choreoathetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151723 BXGD003466 Hypomagnesemia Nutritional and Metabolic Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0221170 BXGD004400 Muscular stiffness Nervous System Diseases
C0231687 BXGD004509 Spastic gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0233844 BXGD004620 Clumsiness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0234518 BXGD004683 Slurred speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235831 BXGD004773 Renal Cell Dysplasia Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0239594 BXGD004987 Short finger
C0239815 BXGD004996 Hand clenching
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0242287 BXGD005145 Isaacs syndrome Musculoskeletal Diseases; Nervous System Diseases
C0266483 BXGD005680 Pachygyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270851 BXGD006118 Benign neonatal epilepsy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270862 BXGD006125 Hemiplegic migraine Nervous System Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344232 BXGD007659 Blurred vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0345392 BXGD007732 Congenital kyphoscoliosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0393576 BXGD008096 Chorea Acanthocytosis Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0393706 BXGD008126 Early infantile epileptic encephalopathy with suppression bursts Nervous System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0476403 BXGD008992 Electromyogram abnormal
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0520966 BXGD009128 Abnormal coordination Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0544645 BXGD009309 Focal Sensory Seizure Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0563243 BXGD009479 Poor coordination Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0575158 BXGD009515 Kyphoscoliosis deformity of spine Musculoskeletal Diseases
C0598275 BXGD009664 Diffuse cerebral atrophy Nervous System Diseases; Mental Disorders
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0600033 BXGD009682 Acquired Kyphoscoliosis Musculoskeletal Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684219 BXGD009789 Myokymia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0740279 BXGD009973 Cerebellar atrophy
C0748607 BXGD010201 Recurrent seizure Nervous System Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1306503 BXGD012363 Congenital exomphalos Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1557375 BXGD013360 Blurred Vision, CTCAE
C1611743 BXGD013456 Familial (FPAH)
C1719788 BXGD013661 Episodic ataxia type 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1720189 BXGD013668 Episodic Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1720416 BXGD013672 Episodic ataxia type 2 (disorder) Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C1834559 BXGD013979 Continuous Muscle Fiber Activity, Hereditary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836508 BXGD014124 Generalized tonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1836542 BXGD014129 Depressed nasal bridge
C1836830 BXGD014165 Developmental regression Mental Disorders
C1840077 BXGD014434 Anteverted nostril
C1843057 BXGD014552 Calf muscle hypertrophy
C1843570 BXGD014595 Tip-toe gait
C1843921 BXGD014620 Postural instability Nervous System Diseases
C1844548 BXGD014642 Hypoplastic finger
C1844906 BXGD014692 Broad finger
C1854301 BXGD015391 Motor delay Mental Disorders
C1854387 BXGD015396 Type 1 muscle fiber predominance
C1857679 BXGD015735 Sloping forehead
C1860834 BXGD016006 Infantile muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1861403 BXGD016045 Variable expressivity
C1867114 BXGD016439 Craniofacial disproportion
C1868682 BXGD016525 Paroxysmal kinesigenic choreoathetosis Nervous System Diseases
C1956415 BXGD016635 Paroxysmal nocturnal dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Cardiovascular Diseases
C1969156 BXGD016761 EEG with burst suppression
C2674766 BXGD017259 Myokymia 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2677843 BXGD017389 Episodic Ataxia, Type 7 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3502809 BXGD019049 Generalized Epilepsy with Febrile Seizures Plus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3536714 BXGD019069 Renal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4016334 BXGD020310 MYOKYMIA 1 WITH HYPOMAGNESEMIA
C4022849 BXGD021012 Absent thumbnail
C4023484 BXGD021201 Uni- and bilateral multifocal epileptiform discharges
C4023499 BXGD021204 Generalized clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4023683 BXGD021240 EEG with spike-wave complexes
C4023986 BXGD021282 Broad phalanx of the toes
C4024923 BXGD021476 Diffuse white matter abnormalities Pathological Conditions, Signs and Symptoms
C4025790 BXGD021791 Specific learning disability
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4049830 BXGD021953 Focal seizures, afebril Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4316810 BXGD022702 Writer's Cramp Nervous System Diseases
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4511005 BXGD022994 Autosomal dominant primary hypomagnesemia with hypocalciuria Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4552000 BXGD023473 Episodic Kinesigenic Dyskinesia 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4553743 BXGD023548 Spasticity, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001842 Bergapten 216.19
BXGC0006115 Xanthotoxin 216.19
BXGC0024988 Nifedipine 346.12
BXGC0027076 Oroidin 386.93
BXGC0034035 Capsaicin 305.2
BXGC0047867 Dalfampridine 94.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein