Showing entry for Voltage-gated potassium channel subunit beta-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013336
Protein NameVoltage-gated potassium channel subunit beta-2
Uniport IdQ13303
GeneKCNAB2
Gene Id8514
DomainAldo_ket_red
Pfam PF00248  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002244 hematopoietic progenitor cell differentiation
Biological Process GO:0070995 NADPH oxidation
Biological Process GO:0050905 neuromuscular process
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0098900 regulation of action potential
Biological Process GO:1901379 regulation of potassium ion transmembrane transport
Biological Process GO:2000008 regulation of protein localization to cell surface
molecular function GO:0004033 aldo-keto reductase (NADP) activity
molecular function GO:0044325 ion channel binding
molecular function GO:0015459 potassium channel regulator activity
molecular function GO:0005249 voltage-gated potassium channel activity
cellular component GO:0043679 axon terminus
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
cellular component GO:0044224 juxtaparanode region of axon
cellular component GO:0016020 membrane
cellular component GO:1990031 pinceau fiber
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0035579 specific granule membrane
cellular component GO:0070821 tertiary granule membrane
cellular component GO:0008076 voltage-gated potassium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-1296071 Potassium Channels
R-HSA-1296072 Voltage gated Potassium channels
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018816 BXGD001234 Heart Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020505 BXGD001412 Hyperphagia Pathological Conditions, Signs and Symptoms
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023221 BXGD001619 Leg Length Inequality Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026034 BXGD001887 Microstomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0032000 BXGD002318 Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0034194 BXGD002472 Pyloric Stenosis Digestive System Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038271 BXGD002742 Stereotyped Behavior Behavior and Behavior Mechanisms
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0039446 BXGD002811 Telangiectasis Cardiovascular Diseases
C0039685 BXGD002825 Tetralogy of Fallot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0078917 BXGD003054 Albinism, Ocular Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C0085271 BXGD003148 Self-Injurious Behavior Behavior and Behavior Mechanisms
C0086237 BXGD003273 Epilepsy, Cryptogenic Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0149955 BXGD003394 Annular pancreas Digestive System Diseases
C0151311 BXGD003412 Cranial nerve palsies Nervous System Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0152423 BXGD003587 Congenital small ears Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Otorhinolaryngologic Diseases
C0158734 BXGD003904 Polydactyly of toes Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221356 BXGD004448 Brachycephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0236018 BXGD004804 Aura Nervous System Diseases
C0241654 BXGD005104 Abnormal heart valve morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0265695 BXGD005566 Congenital fusion of ribs Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266623 BXGD005702 Congenital anomaly of neck Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0268800 BXGD006041 Simple renal cyst Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0277828 BXGD006480 Late fontanel closure
C0332573 BXGD006895 Macule
C0349588 BXGD007933 Short stature
C0375206 BXGD007973 Hemiplegia/hemiparesis
C0409348 BXGD008384 Flexion contracture of proximal interphalangeal joint
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0429028 BXGD008646 QT interval feature (observable entity)
C0557874 BXGD009444 Global developmental delay
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0576226 BXGD009527 Short foot
C0678230 BXGD009750 Congenital Epicanthus
C0751111 BXGD010319 Awakening Epilepsy Nervous System Diseases
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0856748 BXGD011113 Aneurysm of aortic arch Cardiovascular Diseases
C1142166 BXGD011736 Brugada Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1328407 BXGD012465 Hip Dysplasia Musculoskeletal Diseases; Wounds and Injuries
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1836542 BXGD014129 Depressed nasal bridge
C1839731 BXGD014397 11 pairs of ribs
C1842870 BXGD014541 Chromosome 1p36 Deletion Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1842876 BXGD014542 Depressed nasal ridge
C1844505 BXGD014633 Pointed chin
C1848207 BXGD014916 Poor speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848673 BXGD014963 Hypoplastic feet
C1849211 BXGD015023 Generalized hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1849367 BXGD015046 Nasal bridge wide
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1853242 BXGD015322 Midface retrusion
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1855925 BXGD015561 Hyperopia, High Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1861329 BXGD016033 Spinal canal stenosis Musculoskeletal Diseases
C1865014 BXGD016282 Long philtrum
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2132198 BXGD016930 Abnormal blistering of the skin
C2674608 BXGD017250 Feeding difficulties in infancy
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C3277019 BXGD018698 Horizontal eyebrow
C3278923 BXGD018748 Dilated ventricles (finding)
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887499 BXGD019884 Renal cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3887898 BXGD019926 Infantile Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021822 BXGD020807 Abnormality of female external genitalia
C4025329 BXGD021647 Abnormality of the anus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4025749 BXGD021773 Abnormality of the spleen
C4316788 BXGD022697 Abnormality of the intestine
C4551583 BXGD023361 Cerebral cortical atrophy
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721788 BXGD023771 Bifid ribs
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein