Showing entry for Myocilin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019979
Protein NameMyocilin
Uniport IdQ99972
GeneMYOC
Gene Id4653
DomainOLF
Pfam PF02191  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060348 bone development
Biological Process GO:0045162 clustering of voltage-gated sodium channels
Biological Process GO:0038133 ERBB2-ERBB3 signaling pathway
Biological Process GO:0022011 myelination in peripheral nervous system
Biological Process GO:0001953 negative regulation of cell-matrix adhesion
Biological Process GO:0035024 negative regulation of Rho protein signal transduction
Biological Process GO:0051497 negative regulation of stress fiber assembly
Biological Process GO:0031175 neuron projection development
Biological Process GO:0038031 non-canonical Wnt signaling pathway via JNK cascade
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0051894 positive regulation of focal adhesion assembly
Biological Process GO:0051901 positive regulation of mitochondrial depolarization
Biological Process GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:0051496 positive regulation of stress fiber assembly
Biological Process GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0043408 regulation of MAPK cascade
Biological Process GO:0014734 skeletal muscle hypertrophy
molecular function GO:0001968 fibronectin binding
molecular function GO:0005109 frizzled binding
molecular function GO:0046872 metal ion binding
molecular function GO:0032027 myosin light chain binding
molecular function GO:0030971 receptor tyrosine kinase binding
cellular component GO:0005929 cilium
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0070062 extracellular exosome
cellular component GO:0005615 extracellular space
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005758 mitochondrial intermembrane space
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0033268 node of Ranvier
cellular component GO:0005791 rough endoplasmic reticulum
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017605 BXGD001126 Angle Closure Glaucoma Eye Diseases
C0017606 BXGD001127 Primary angle-closure glaucoma Eye Diseases
C0017612 BXGD001129 Glaucoma, Open-Angle Eye Diseases
C0017662 BXGD001140 Glomerulonephritis, Membranoproliferative Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020302 BXGD001373 Hydrophthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027720 BXGD002028 Nephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027809 BXGD002040 Neurilemmoma Neoplasms
C0028840 BXGD002089 Ocular Hypertension Eye Diseases
C0029132 BXGD002117 Disorder of the optic nerve Eye Diseases; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0034951 BXGD002498 Refractive Errors Eye Diseases
C0035302 BXGD002527 Retinal Artery Occlusion Eye Diseases; Cardiovascular Diseases
C0035305 BXGD002529 Retinal Detachment Eye Diseases
C0035328 BXGD002537 Retinal Vein Occlusion Eye Diseases; Cardiovascular Diseases
C0042798 BXGD003003 Low Vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0085648 BXGD003221 Synovial Cyst Neoplasms
C0152136 BXGD003548 Low Tension Glaucoma Eye Diseases
C0152191 BXGD003556 Scotoma, Central Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0178664 BXGD004032 Glomerulosclerosis (disorder) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0235752 BXGD004766 Port-Wine Stain Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0240063 BXGD005015 Coloboma of iris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0241688 BXGD005107 Peripheral visual field loss
C0271148 BXGD006165 Secondary Open Angle Glaucoma Eye Diseases
C0271183 BXGD006169 Severe myopia Eye Diseases
C0271342 BXGD006186 Glaucomatous atrophy of optic disc Eye Diseases; Nervous System Diseases
C0311237 BXGD006868 Goniodysgenesis
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0339576 BXGD007272 Glaucoma due to combination of mechanisms Eye Diseases
C0339578 BXGD007273 Corticosteroid-induced glaucoma Eye Diseases
C0344299 BXGD007663 Temporal pallor of optic disc Eye Diseases; Nervous System Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0494261 BXGD009023 Combined immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0543991 BXGD009305 Chronic primary angle closure glaucoma Eye Diseases
C0595921 BXGD009626 Intraocular pressure disorder Eye Diseases
C0595936 BXGD009628 Aqueous Humor Disorders Eye Diseases
C0851409 BXGD010922 Glaucoma and ocular hypertension Eye Diseases
C0857070 BXGD011134 Chronic open angle glaucoma Eye Diseases
C1258666 BXGD011825 Myxoid cyst Neoplasms; Skin and Connective Tissue Diseases
C1299694 BXGD012264 Glaucomatous visual field defect
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1533041 BXGD013307 Primary congenital glaucoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1611743 BXGD013456 Familial (FPAH)
C1737225 BXGD013724 Mesangioproliferative glomerulonephritis
C1842028 BXGD014488 GLAUCOMA 1, OPEN ANGLE, A Eye Diseases
C1856439 BXGD015607 GLAUCOMA 3, PRIMARY CONGENITAL, A Eye Diseases
C1866550 BXGD016407 GLAUCOMA 3, PRIMARY CONGENITAL, A, DIGENIC
C2718001 BXGD017521 Protein Misfolding Disorders Nutritional and Metabolic Diseases
C2981140 BXGD018209 Glaucoma of childhood Eye Diseases
C3152182 BXGD018461 Anterior chamber anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3275963 BXGD018681 Abnormal iris vasculature
C3495488 BXGD018987 Axenfeld-Rieger syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386 BXGD019284 Abnormal vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3711383 BXGD019388 Early-Onset Glaucoma Eye Diseases
C3805911 BXGD019493 Increased cup-to-disc ratio
C3887709 BXGD019918 Optic Neuropathy Eye Diseases; Nervous System Diseases
C4016750 BXGD020370 GLAUCOMA 1, OPEN ANGLE, A, DIGENIC
C4023166 BXGD021131 Abnormality of T cell physiology
C4023612 BXGD021228 Abnormality of cellular immune system
C4025845 BXGD021825 Abnormality iris morphology
C4068743 BXGD022002 Juvenile open angle
C4085595 BXGD022120 AL-RAQAD SYNDROME
C4476793 BXGD022872 Abnormal cell morphology
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002071 Apigenin 270.24
BXGC0002586 Calcium 40.08
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein