Showing entry for Nucleotide-binding oligomerization domain-containing protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022213
Protein NameNucleotide-binding oligomerization domain-containing protein 1
Uniport IdQ9Y239
GeneNOD1
Gene Id10392
DomainCARD; LRR_6; NACHT; NLRC4_HD2; NOD2_WH
Pfam PF00619   PF13516   PF05729   PF17776   PF17779  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05131 Shigellosis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05133 Pertussis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0006915 apoptotic process
Biological Process GO:0071225 cellular response to muramyl dipeptide
Biological Process GO:0006952 defense response
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0016045 detection of bacterium
Biological Process GO:0009595 detection of biotic stimulus
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0070498 interleukin-1-mediated signaling pathway
Biological Process GO:0032637 interleukin-8 production
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0007254 JNK cascade
Biological Process GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
Biological Process GO:0002221 pattern recognition receptor signaling pathway
Biological Process GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0002606 positive regulation of dendritic cell antigen processing and presentation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:1901224 positive regulation of NIK/NF-kappaB signaling
Biological Process GO:0051000 positive regulation of nitric-oxide synthase activity
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:1904417 positive regulation of xenophagy
Biological Process GO:0007165 signal transduction
molecular function GO:0005524 ATP binding
molecular function GO:0050700 CARD domain binding
molecular function GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
molecular function GO:0042802 identical protein binding
molecular function GO:0038187 pattern recognition receptor activity
molecular function GO:0042834 peptidoglycan binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0046658 anchored component of plasma membrane
cellular component GO:0016324 apical plasma membrane
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0045335 phagocytic vesicle
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-392499 Metabolism of proteins
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-446652 Interleukin-1 family signaling
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450294 MAP kinase activation
R-HSA-450302 activated TAK1 mediates p38 MAPK activation
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-5688426 Deubiquitination
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-597592 Post-translational protein modification
R-HSA-9020702 Interleukin-1 signaling
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001342 BXGD000042 Acute periodontitis Stomatognathic Diseases
C0002893 BXGD000150 Refractory anemias Hemic and Lymphatic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004030 BXGD000246 Aspergillosis Infections
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008149 BXGD000520 Chlamydia Infections Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0008373 BXGD000536 Cholesteatoma Skin and Connective Tissue Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011311 BXGD000714 Dengue Fever Infections
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013238 BXGD000806 Dry Eye Syndromes Eye Diseases
C0013295 BXGD000812 Duodenal Ulcer Digestive System Diseases
C0013371 BXGD000823 Shigella Infections Digestive System Diseases; Infections
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017152 BXGD001096 Gastritis Digestive System Diseases
C0017178 BXGD001102 Gastrointestinal Diseases Digestive System Diseases
C0018081 BXGD001171 Gonorrhea Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0018378 BXGD001190 Guillain-Barre Syndrome Immune System Diseases; Nervous System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023532 BXGD001685 Leukoplakia, Oral Pathological Conditions, Signs and Symptoms; Neoplasms; Stomatognathic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025500 BXGD001874 Mesothelioma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0030920 BXGD002263 Peptic Ulcer Digestive System Diseases
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0031106 BXGD002283 Aggressive Periodontitis Stomatognathic Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0041956 BXGD002942 Ureteral obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042170 BXGD002969 Uveomeningoencephalitic Syndrome Eye Diseases; Immune System Diseases; Nervous System Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0149939 BXGD003390 Obstructive nephropathy Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0178238 BXGD004020 Intestinal infectious disease (disorder) Digestive System Diseases; Infections
C0235989 BXGD004801 Renal interstitial fibrosis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases
C0238013 BXGD004855 Invasive aspergillosis Infections
C0238790 BXGD004956 bone destruction
C0242172 BXGD005138 Pelvic Inflammatory Disease Female Urogenital Diseases and Pregnancy Complications; Infections
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242647 BXGD005184 Mucosa-Associated Lymphoid Tissue Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0243038 BXGD005211 Carcinoma, Lewis Lung Neoplasms
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0264684 BXGD005411 Coronary arteritis Cardiovascular Diseases
C0267055 BXGD005729 Erosive esophagitis Digestive System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0314719 BXGD006890 Dryness of eye Eye Diseases
C0334037 BXGD006980 Intestinal metaplasia
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0392885 BXGD008071 High density lipoprotein measurement
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0456065 BXGD008862 Infant, Extremely Low Birth Weight
C0518948 BXGD009072 Chlamydia trachomatis infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0702166 BXGD009912 Acne Skin and Connective Tissue Diseases
C0850666 BXGD010901 Infection caused by Helicobacter pylori Infections
C0854706 BXGD011025 Neonatal infection
C0920646 BXGD011471 Ischemia of kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1561989 BXGD013368 Limbal stem cell deficiency Eye Diseases
C1611743 BXGD013456 Familial (FPAH)
C1658953 BXGD013486 tumor vasculature
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1850900 BXGD015186 Familial primary gastric lymphoma Digestive System Diseases; Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1853926 BXGD015365 NONAKA MYOPATHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1861303 BXGD016026 SYNOVITIS, GRANULOMATOUS, WITH UVEITIS AND CRANIAL NEUROPATHIES (disorder) Eye Diseases; Musculoskeletal Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1960636 BXGD016668 Dysglycemia
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714514 BXGD019409 Infection Infections
C3843756 BXGD019806 Ulcerative colitis or Crohn's
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C3890941 BXGD020029 Acute Motor Axonal Neuropathy Immune System Diseases; Nervous System Diseases
C4082937 BXGD022095 Necrotizing enterocolitis in fetus OR newborn Digestive System Diseases
C4290046 BXGD022507 trachomatis
C4546431 BXGD023297 Exacerbation of allergic asthma
C4551910 BXGD023440 Acute Inflammatory Demyelinating Polyneuropathy Immune System Diseases; Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005319 Garcinone E 464.55
BXGC0036864 Cyclovalone 366.15
BXGC0049477 Moronic Acid 454.34
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein