Showing entry for Aromatic-L-amino-acid decarboxylase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008594
Protein NameAromatic-L-amino-acid decarboxylase
Uniport IdP20711
GeneDDC
Gene Id1644
DomainPyridoxal_deC
Pfam PF00282  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00350 Tyrosine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00360 Phenylalanine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00380 Tryptophan metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
6. Human Diseases 6.5 Substance dependence hsa05030 Cocaine addiction
6. Human Diseases 6.5 Substance dependence hsa05031 Amphetamine addiction
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015842 aminergic neurotransmitter loading into synaptic vesicle
Biological Process GO:0042423 catecholamine biosynthetic process
Biological Process GO:0006584 catecholamine metabolic process
Biological Process GO:0006520 cellular amino acid metabolic process
Biological Process GO:0071312 cellular response to alkaloid
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0042416 dopamine biosynthetic process
Biological Process GO:0046219 indolalkylamine biosynthetic process
Biological Process GO:0033076 isoquinoline alkaloid metabolic process
Biological Process GO:0010259 multicellular organism aging
Biological Process GO:0052314 phytoalexin metabolic process
Biological Process GO:0046684 response to pyrethroid
Biological Process GO:0042427 serotonin biosynthetic process
molecular function GO:0016597 amino acid binding
molecular function GO:0004058 aromatic-L-amino-acid decarboxylase activity
molecular function GO:0016831 carboxy-lyase activity
molecular function GO:0019899 enzyme binding
molecular function GO:0036468 L-dopa decarboxylase activity
molecular function GO:0019904 protein domain specific binding
molecular function GO:0030170 pyridoxal phosphate binding
cellular component GO:0030424 axon
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0043025 neuronal cell body
cellular component GO:0008021 synaptic vesicle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-209776 Metabolism of amine-derived hormones
R-HSA-209905 Catecholamine biosynthesis
R-HSA-209931 Serotonin and melatonin biosynthesis
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001403 BXGD000048 Addison Disease Immune System Diseases; Endocrine System Diseases
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004763 BXGD000289 Barrett Esophagus Digestive System Diseases; Neoplasms
C0004930 BXGD000294 Behavior Disorders Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006012 BXGD000360 Borderline Personality Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007095 BXGD000423 Carcinoid Tumor Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0008311 BXGD000526 Cholangitis Digestive System Diseases
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013386 BXGD000827 Dyskinesia, Drug-Induced Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Chemically-Induced Disorders
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0019187 BXGD001296 Hepatitis, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0019880 BXGD001351 Homocystinuria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Nervous System Diseases
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0020541 BXGD001424 Portal Hypertension Digestive System Diseases
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023051 BXGD001602 Laryngeal Diseases Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026205 BXGD001891 Miosis disorder Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027429 BXGD001987 Nasal obstruction present finding Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0034935 BXGD002497 Babinski Reflex
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036349 BXGD002604 Paranoid Schizophrenia Mental Disorders
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0040411 BXGD002859 Tongue Neoplasms Neoplasms; Stomatognathic Diseases
C0041671 BXGD002930 Attention Deficit Disorder Mental Disorders
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042769 BXGD002999 Virus Diseases Infections
C0085583 BXGD003194 Choreoathetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085633 BXGD003216 Mood swings Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085637 BXGD003219 Oculogyric crisis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085859 BXGD003254 Polyglandular Type I Autoimmune Syndrome Immune System Diseases; Endocrine System Diseases
C0086439 BXGD003284 Hypokinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0154723 BXGD003737 Migraine with Aura Nervous System Diseases
C0175693 BXGD004001 Russell-Silver syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0234366 BXGD004652 Ataxic
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0242423 BXGD005164 Ramsay Hunt Paralysis Syndrome Nervous System Diseases
C0242596 BXGD005181 Neoplasm, Residual Pathological Conditions, Signs and Symptoms; Neoplasms
C0278694 BXGD006564 Disseminated neuroblastoma Neoplasms
C0279671 BXGD006677 Cervical Squamous Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0338480 BXGD007186 Common Migraine Nervous System Diseases
C0342190 BXGD007440 C-cell hyperplasia of thyroid Pathological Conditions, Signs and Symptoms; Endocrine System Diseases
C0342686 BXGD007526 Aromatic amino acid decarboxylase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0376338 BXGD007990 Diagnosis, Psychiatric Mental Disorders
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424503 BXGD008532 Dysmorphic facies
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0431375 BXGD008677 Classical Lissencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0438696 BXGD008805 Suicidal Behavior and Behavior Mechanisms
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0557874 BXGD009444 Global developmental delay
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0751093 BXGD010317 Dystonia, Limb Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0752097 BXGD010659 Autosomal Dominant Juvenile Parkinson Disease Nervous System Diseases
C0752098 BXGD010660 Autosomal Dominant Parkinsonism Nervous System Diseases
C0752100 BXGD010661 Autosomal Recessive Parkinsonism Nervous System Diseases
C0752101 BXGD010662 Parkinsonism, Experimental Nervous System Diseases
C0752104 BXGD010663 Familial Juvenile Parkinsonism Nervous System Diseases
C0752105 BXGD010664 Parkinsonism, Juvenile Nervous System Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0936215 BXGD011476 Vitamin B 6 Deficiency Nutritional and Metabolic Diseases
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1135161 BXGD011690 Stage 4S neuroblastoma
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1257877 BXGD011812 Pheochromocytoma, Extra-Adrenal Neoplasms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1291564 BXGD012219 Deficiency of aromatic-L-amino-acid decarboxylase
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1611743 BXGD013456 Familial (FPAH)
C1820737 BXGD013762 Temperature instability
C1833921 BXGD013946 Familial medullary thyroid carcinoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C1836996 BXGD014183 Disproportionate tall stature
C1837639 BXGD014252 Intermittent hypothermia Pathological Conditions, Signs and Symptoms
C1838391 BXGD014313 Limb hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1838993 BXGD014351 Episodic vomiting Pathological Conditions, Signs and Symptoms
C1839839 BXGD014416 MAJOR AFFECTIVE DISORDER 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C1847515 BXGD014869 Paroxysmal involuntary eye movements
C1851920 BXGD015246 Dopa-Responsive Dystonia Nervous System Diseases
C1852197 BXGD015264 MAJOR AFFECTIVE DISORDER 1 Mental Disorders
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1868675 BXGD016520 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE Nervous System Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1970943 BXGD016852 MAJOR AFFECTIVE DISORDER 4 Mental Disorders
C1970945 BXGD016853 MAJOR AFFECTIVE DISORDER 6 Mental Disorders
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2674608 BXGD017250 Feeding difficulties in infancy
C2700438 BXGD017469 MAJOR AFFECTIVE DISORDER 7 Mental Disorders
C2700439 BXGD017470 MAJOR AFFECTIVE DISORDER 8 Mental Disorders
C2700440 BXGD017471 MAJOR AFFECTIVE DISORDER 9 Mental Disorders
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2747816 BXGD017577 Complicated malaria Infections
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3668948 BXGD019321 Circling behavior
C3888018 BXGD019942 Congenital Hyperinsulinism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases
C4022801 BXGD021002 Elevated CSF dopamine level
C4025871 BXGD021839 Abnormality of the face
C4046029 BXGD021889 Mental Disorders, Severe Mental Disorders
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4087504 BXGD022156 Peritoneal dissemination
C4280803 BXGD022407 Decreased CSF homovanillic acid
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4529962 BXGD023178 Fatty Liver Disease
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4552810 BXGD023525 Irritability, CTCAE
C4722306 BXGD023798 Metastatic Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000194 Sanguinarine 332.33
BXGC0003705 Chloride 35.45
BXGC0012352 Chelerythrine 348.12
BXGC0027126 dihydrosanguinarine 333.1
BXGC0036203 nitidine 348.12
BXGC0043088 Pyridoxal Phosphate 247.02
BXGC0047281 Berberine 336.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein