Showing entry for T-box transcription factor TBX3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004128
Protein NameT-box transcription factor TBX3
Uniport IdO15119
GeneTBX3
Gene Id6926
DomainT-box; TBX
Pfam PF00907   PF12598  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009887 animal organ morphogenesis
Biological Process GO:0008595 anterior/posterior axis specification, embryo
Biological Process GO:0003167 atrioventricular bundle cell differentiation
Biological Process GO:0001568 blood vessel development
Biological Process GO:0060444 branching involved in mammary gland duct morphogenesis
Biological Process GO:0003205 cardiac chamber development
Biological Process GO:0060923 cardiac muscle cell fate commitment
Biological Process GO:0007569 cell aging
Biological Process GO:0001708 cell fate specification
Biological Process GO:0090398 cellular senescence
Biological Process GO:0007417 central nervous system development
Biological Process GO:0042733 embryonic digit morphogenesis
Biological Process GO:0035115 embryonic forelimb morphogenesis
Biological Process GO:0035116 embryonic hindlimb morphogenesis
Biological Process GO:0030540 female genitalia development
Biological Process GO:0046884 follicle-stimulating hormone secretion
Biological Process GO:0035136 forelimb morphogenesis
Biological Process GO:0001947 heart looping
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0021761 limbic system development
Biological Process GO:0032275 luteinizing hormone secretion
Biological Process GO:0030539 male genitalia development
Biological Process GO:0030879 mammary gland development
Biological Process GO:0060596 mammary placode formation
Biological Process GO:0048332 mesoderm morphogenesis
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0030857 negative regulation of epithelial cell differentiation
Biological Process GO:0045662 negative regulation of myoblast differentiation
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:0045787 positive regulation of cell cycle
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:2000648 positive regulation of stem cell proliferation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0060021 roof of mouth development
Biological Process GO:0060931 sinoatrial node cell development
Biological Process GO:0001501 skeletal system development
Biological Process GO:0051145 smooth muscle cell differentiation
Biological Process GO:0010159 specification of animal organ position
Biological Process GO:0019827 stem cell population maintenance
Biological Process GO:0072105 ureteric peristalsis
Biological Process GO:0060412 ventricular septum morphogenesis
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
molecular function GO:0001102 RNA polymerase II activating transcription factor binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0001085 RNA polymerase II transcription factor binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:1990837 sequence-specific double-stranded DNA binding
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0003466 BXGD000193 Anus, Imperforate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004245 BXGD000264 Atrioventricular Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0012236 BXGD000772 DiGeorge Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0015826 BXGD001022 Fenestration (morphologic abnormality)
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0019296 BXGD001316 Inguinal Hernia, Indirect Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020608 BXGD001443 Hypodontia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0020636 BXGD001456 underdevelopment Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034012 BXGD002449 Delayed Puberty Endocrine System Diseases
C0034194 BXGD002472 Pyloric Stenosis Digestive System Diseases
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0035436 BXGD002550 Rheumatic Fever Infections; Musculoskeletal Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040128 BXGD002844 Thyroid Diseases Endocrine System Diseases
C0040427 BXGD002864 Tooth Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0041207 BXGD002898 Truncus Arteriosus, Persistent Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152427 BXGD003590 Polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0152436 BXGD003591 Hymen, Imperforate Pathological Conditions, Signs and Symptoms
C0152438 BXGD003592 Sprengel deformity Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0158731 BXGD003902 Congenital pectus carinatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0178664 BXGD004032 Glomerulosclerosis (disorder) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0206762 BXGD004290 Limb Deformities, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220697 BXGD004324 POLYDACTYLY, POSTAXIAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220704 BXGD004327 Shprintzen syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0235480 BXGD004751 Paroxysmal atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238441 BXGD004932 Subglottic stenosis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0262374 BXGD005230 Stricture of anus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0264303 BXGD005379 Laryngomalacia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0264490 BXGD005394 Acute respiratory failure Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Respiratory Tract Diseases
C0264886 BXGD005432 Conduction disorder of the heart Cardiovascular Diseases
C0265264 BXGD005490 Holt-Oram syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Cardiovascular Diseases
C0265594 BXGD005553 Congenital absence of hand Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266009 BXGD005604 Congenital absence of breast Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266013 BXGD005606 Congenital hypoplasia of breast Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266231 BXGD005633 Ectopic anus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0266295 BXGD005645 Congenital hypoplasia of kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266383 BXGD005660 Uterine Anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0269269 BXGD006058 Inversion of nipple (disorder) Skin and Connective Tissue Diseases
C0271561 BXGD006213 Somatotropin deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0346629 BXGD007831 Malignant neoplasm of large intestine Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0409348 BXGD008384 Flexion contracture of proximal interphalangeal joint
C0426799 BXGD008578 Congenital hypoplasia of clavicle Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0426807 BXGD008581 Short clavicle
C0426868 BXGD008591 Absence of hand
C0428908 BXGD008641 Sinus Node Dysfunction (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0431904 BXGD008713 Ulnar polydactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0432355 BXGD008780 Hypoplasia of nipple
C0496956 BXGD009052 Neoplasm of uncertain or unknown behavior of breast Neoplasms; Skin and Connective Tissue Diseases
C0520927 BXGD009124 Decreased fertility
C0524730 BXGD009243 Odontome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0559106 BXGD009465 Ventricular preexcitation Pathological Conditions, Signs and Symptoms
C0574785 BXGD009506 Lower Urinary Tract Symptoms Pathological Conditions, Signs and Symptoms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0685381 BXGD009809 Congenital hypoplasia of radius Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740404 BXGD009991 Limb defects
C0741916 BXGD010044 Cardiac defects
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0854778 BXGD011033 Pancreatic carcinoma resectable Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0858252 BXGD011172 Breast adenocarcinoma Neoplasms; Skin and Connective Tissue Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948364 BXGD011530 Periprosthetic osteolysis Musculoskeletal Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1321551 BXGD012436 Shprintzen-Goldberg syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C1334274 BXGD012695 Invasive Carcinoma Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1405984 BXGD013029 Absent radius
C1442978 BXGD013065 Hernia of abdominal wall Pathological Conditions, Signs and Symptoms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1827293 BXGD013768 Carcinoma of urinary bladder, invasive Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1832117 BXGD013798 Short humerus
C1832160 BXGD013803 Abnormality of temperature regulation
C1837218 BXGD014207 Cleft palate, isolated Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1837279 BXGD014217 Hypoplastic toenails
C1837315 BXGD014218 COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
C1839829 BXGD014413 Short distal phalanx of finger
C1846434 BXGD014814 Hypoplastic scapulae
C1853238 BXGD015320 Conotruncal defect
C1857206 BXGD015684 Sparse lateral eyebrow
C1858539 BXGD015803 Shawl scrotum
C1858574 BXGD015810 Sparse axillary hair
C1859392 BXGD015885 Absent axillary hair
C1859775 BXGD015930 Anterior pituitary hypoplasia
C1860614 BXGD015992 ULNAR HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1862083 BXGD016099 Short 4th toe
C1865571 BXGD016330 Aplasia/Hypoplasia of the ulna
C1866994 BXGD016431 Ulnar-mammary syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1867000 BXGD016432 Hypoplastic/absent/deformed radius
C1867003 BXGD016433 Axillary apocrine gland hypoplasia
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2675481 BXGD017292 COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
C2677123 BXGD017364 COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
C2678397 BXGD017406 Aplasia of the ulna
C2919142 BXGD017867 Short Stature, CTCAE
C2981150 BXGD018211 Uranostaphyloschisis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3279571 BXGD018763 Ectopic posterior pituitary
C3554460 BXGD019215 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3714796 BXGD019434 Isolated somatotropin deficiency
C4021111 BXGD020558 Short 5th toe
C4021742 BXGD020750 Abnormality of the humerus
C4021744 BXGD020751 Abnormality of the wrist
C4021785 BXGD020778 Abnormality of the metacarpal bones Musculoskeletal Diseases
C4021792 BXGD020783 Abnormality of the clavicle
C4024213 BXGD021304 Aplasia of the pectoralis major muscle
C4025467 BXGD021662 Deformed radius
C4025675 BXGD021726 Abnormality of the radius
C4228778 BXGD022292 Abnormality of radial ray
C4551936 BXGD023442 Anal Stenosis, CTCAE
C4552011 BXGD023477 Gonadotropin deficiency
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein