Showing entry for Citron Rho-interacting kinase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004072
Protein NameCitron Rho-interacting kinase
Uniport IdO14578
GeneCIT
Gene Id11113
DomainCNH; PH; Pkinase
Pfam PF00780   PF00169   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:0048699 generation of neurons
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0051402 neuron apoptotic process
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0032467 positive regulation of cytokinesis
molecular function GO:0005524 ATP binding
molecular function GO:0046872 metal ion binding
molecular function GO:0030165 PDZ domain binding
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0097110 scaffold protein binding
molecular function GO:0017124 SH3 domain binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0016020 membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-195258 RHO GTPase Effectors
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5625900 RHO GTPases activate CIT
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005747 BXGD000332 Blepharospasm Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006370 BXGD000394 Bulimia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0011206 BXGD000703 Delirium Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013720 BXGD000861 Ehlers-Danlos Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0030662 BXGD002250 Gambling, Pathological Mental Disorders; Behavior and Behavior Mechanisms
C0032897 BXGD002378 Prader-Willi Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038868 BXGD002781 Progressive supranuclear palsy Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042580 BXGD002992 Vesico-Ureteral Reflux Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085606 BXGD003201 Urgency of micturition Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0150045 BXGD003400 Urge Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152421 BXGD003586 Macrotia
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178417 BXGD004025 Anhedonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0240543 BXGD005042 Bulbous nose
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0266294 BXGD005644 Unilateral agenesis of kidney Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0266483 BXGD005680 Pachygyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266491 BXGD005683 Neuronal heterotopia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0268070 BXGD005808 Hypocupremia
C0270736 BXGD006096 Essential Tremor Nervous System Diseases
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0280781 BXGD006758 Adult Pilocytic Astrocytoma Neoplasms
C0334583 BXGD007124 Pilocytic Astrocytoma Neoplasms
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349588 BXGD007933 Short stature
C0393570 BXGD008093 Corticobasal degeneration Nervous System Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0423109 BXGD008470 Upward slant of palpebral fissure
C0427460 BXGD008616 Red cell distribution width determination
C0431350 BXGD008668 Primary microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0750940 BXGD010260 Tremor, Rubral Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751772 BXGD010583 REM Sleep Behavior Disorder Nervous System Diseases; Mental Disorders
C0752121 BXGD010669 Spinocerebellar Ataxia Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0854776 BXGD011031 Pancreatic carcinoma non-resectable Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0854802 BXGD011036 Recurrent Chronic Lymphoid Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0860603 BXGD011236 Anxiety symptoms
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332995 BXGD012575 Childhood Pilocytic Astrocytoma Neoplasms
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1609433 BXGD013438 Congenital absence of kidneys syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1836543 BXGD014130 Thick vermilion border
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1842688 BXGD014532 Hypoplasia of the brainstem
C1846707 BXGD014836 SPINOCEREBELLAR ATAXIA 17 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1849172 BXGD015019 Frontal lobe hypoplasia
C1851920 BXGD015246 Dopa-Responsive Dystonia Nervous System Diseases
C1857679 BXGD015735 Sloping forehead
C1860787 BXGD015997 DOWN SYNDROME CRITICAL REGION Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1861403 BXGD016045 Variable expressivity
C1865017 BXGD016283 Thin upper lip vermilion
C1868681 BXGD016524 DYSTONIA 12 Nervous System Diseases
C1955760 BXGD016608 Idiopathic normal pressure hydrocephalus (INPH)
C1956147 BXGD016622 Microlissencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2267227 BXGD017015 Bulimia Nervosa Mental Disorders
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2749675 BXGD017631 Cortical gyral simplification
C2919142 BXGD017867 Short Stature, CTCAE
C3278923 BXGD018748 Dilated ventricles (finding)
C3494361 BXGD018964 Prodromal Stage Pathological Conditions, Signs and Symptoms
C3711387 BXGD019391 Autosomal Recessive Primary Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3809431 BXGD019587 MICROCEPHALY 11, PRIMARY, AUTOSOMAL RECESSIVE
C3887638 BXGD019906 Failure to thrive in infant Pathological Conditions, Signs and Symptoms
C3887938 BXGD019929 Deuteranomaly Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4014891 BXGD020170 Renal abnormalities
C4021741 BXGD020749 Abnormal cortical bone morphology
C4275179 BXGD022368 Young onset Parkinson disease Nervous System Diseases
C4302185 BXGD022525 Atypical Parkinsonism Nervous System Diseases
C4310723 BXGD022639 MICROCEPHALY 17, PRIMARY, AUTOSOMAL RECESSIVE
C4551563 BXGD023351 Microcephaly (physical finding)
C4553743 BXGD023548 Spasticity, CTCAE
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001545 Harmine 212.25
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein