Showing entry for Transcription initiation factor TFIID subunit 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008678
Protein NameTranscription initiation factor TFIID subunit 1
Uniport IdP21675
GeneTAF1
Gene Id6872
DomainBromodomain; DUF3591; TBP-binding; zf-CCHC_6
Pfam PF00439   PF12157   PF09247   PF15288  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.1 Transcription hsa03022 Basal transcription factors
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007049 cell cycle
Biological Process GO:0071318 cellular response to ATP
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0034644 cellular response to UV
Biological Process GO:0030901 midbrain development
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:1905524 negative regulation of protein autoubiquitination
Biological Process GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:2000825 positive regulation of androgen receptor activity
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0050821 protein stabilization
Biological Process GO:1902806 regulation of cell cycle G1/S phase transition
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
Biological Process GO:0051123 RNA polymerase II preinitiation complex assembly
Biological Process GO:0006366 transcription by RNA polymerase II
Biological Process GO:0036369 transcription factor catabolic process
Biological Process GO:0006367 transcription initiation from RNA polymerase II promoter
Biological Process GO:0006361 transcription initiation from RNA polymerase I promoter
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
Biological Process GO:0016032 viral process
molecular function GO:0005524 ATP binding
molecular function GO:0140416 DNA-binding transcription factor inhibitor activity
molecular function GO:0004402 histone acetyltransferase activity
molecular function GO:0016301 kinase activity
molecular function GO:0070577 lysine-acetylated histone binding
molecular function GO:0035257 nuclear hormone receptor binding
molecular function GO:0002039 p53 binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0001181 RNA polymerase I general transcription initiation factor activity
molecular function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
molecular function GO:0016251 RNA polymerase II general transcription initiation factor activity
molecular function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:0017025 TBP-class protein binding
molecular function GO:0008134 transcription factor binding
molecular function GO:0061631 ubiquitin conjugating enzyme activity
cellular component GO:0071339 MLL1 complex
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005669 transcription factor TFIID complex
cellular component GO:0005667 transcription regulator complex
Reactome
Pathway Id Pathway Name
R-HSA-162587 HIV Life Cycle
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-162906 HIV Infection
R-HSA-1643685 Disease
R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-212436 Generic Transcription Pathway
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5663205 Infectious disease
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005747 BXGD000332 Blepharospasm Eye Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007133 BXGD000442 Carcinoma, Papillary Neoplasms
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013423 BXGD000838 Dystonia Musculorum Deformans Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0015300 BXGD000973 Exophthalmos Eye Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023066 BXGD001605 Laryngospasm Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023798 BXGD001702 Lipoma Neoplasms
C0023882 BXGD001710 Little's Disease Nervous System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027849 BXGD002049 Neuroleptic Malignant Syndrome Nervous System Diseases; Chemically-Induced Disorders
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032290 BXGD002345 Aspiration Pneumonia Infections; Respiratory Tract Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0151468 BXGD003424 Thyroid Gland Follicular Adenoma Neoplasms; Endocrine System Diseases
C0152421 BXGD003586 Macrotia
C0154671 BXGD003726 Degenerative brain disorder Nervous System Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205647 BXGD004099 Follicular adenoma Neoplasms
C0206682 BXGD004237 Follicular thyroid carcinoma Neoplasms
C0231688 BXGD004510 Gait, Shuffling Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234379 BXGD004662 Resting Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0238461 BXGD004936 Anaplastic thyroid carcinoma Neoplasms
C0239234 BXGD004974 Low set ears
C0239842 BXGD005001 Tremor of hands
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0240543 BXGD005042 Bulbous nose
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0241442 BXGD005099 Protrusion of tongue
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0266006 BXGD005603 Pili torti-deafness syndrome Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0267071 BXGD005730 Oropharyngeal Dysphagia Digestive System Diseases; Otorhinolaryngologic Diseases
C0271441 BXGD006203 Chronic otitis media Otorhinolaryngologic Diseases
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0338106 BXGD007167 Adenocarcinoma of colon Digestive System Diseases; Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0423110 BXGD008471 Downward slant of palpebral fissure
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0426429 BXGD008564 Broad nasal tip
C0426870 BXGD008592 Large hand
C0426980 BXGD008599 Motor symptoms
C0431447 BXGD008690 Synophrys Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0432072 BXGD008718 Dysmorphic features
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0521525 BXGD009139 Short neck
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678230 BXGD009750 Congenital Epicanthus
C0686347 BXGD009832 Tardive Dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0751093 BXGD010317 Dystonia, Limb Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752210 BXGD010697 Dyskinesias, Paroxysmal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1511789 BXGD013183 Desmoplastic
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1836047 BXGD014074 Long face
C1836542 BXGD014129 Depressed nasal bridge
C1836696 BXGD014151 Lower limb hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1837260 BXGD014214 Prominent forehead
C1837404 BXGD014229 High, narrow palate
C1837658 BXGD014257 Gross motor development delay Mental Disorders
C1837732 BXGD014261 Thickened helices
C1839130 BXGD014358 Dystonia 3, Torsion, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1840379 BXGD014459 Cerebellar vermis hypoplasia
C1842060 BXGD014491 Prominent supraorbital ridges
C1843367 BXGD014576 Poor school performance
C1843921 BXGD014620 Postural instability Nervous System Diseases
C1844505 BXGD014633 Pointed chin
C1844820 BXGD014681 Range of joint movement increased
C1845977 BXGD014769 X- linked recessive
C1846868 BXGD014846 Parkinsonism with favorable response to dopaminergic medication Nervous System Diseases
C1850044 BXGD015099 Prominent protruding coccyx
C1851085 BXGD015191 Severe expressive language delay
C1851841 BXGD015242 ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C1853487 BXGD015340 Thick eyebrow
C1853738 BXGD015357 Long eyelashes
C1855285 BXGD015483 Protruding ear
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859717 BXGD015924 Depressed nasal tip
C1859778 BXGD015931 Postnatal growth retardation
C1865014 BXGD016282 Long philtrum
C1865017 BXGD016283 Thin upper lip vermilion
C1866934 BXGD016427 Reduced tendon reflexes Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1968942 BXGD016743 Abnormal sacral segmentation
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2751067 BXGD017690 Parkinsonism-Dystonia, Infantile Nervous System Diseases
C2986717 BXGD018241 Anti-N-Methyl-D-Aspartate Receptor Encephalitis Neoplasms; Immune System Diseases; Nervous System Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3714760 BXGD019432 Drug-induced tardive dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Chemically-Induced Disorders
C3888090 BXGD019948 Early onset torsion dystonia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4021580 BXGD020682 Progressive extrapyramidal muscular rigidity
C4022490 BXGD020906 Prominent coccyx
C4023172 BXGD021135 Broad chin
C4024168 BXGD021296 Thickened ears
C4225418 BXGD022273 MENTAL RETARDATION, X-LINKED, SYNDROMIC 33
C4477013 BXGD022904 Impaired oropharyngeal swallow response Digestive System Diseases; Otorhinolaryngologic Diseases
C4551676 BXGD023385 Laryngismus stridulus Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein