Showing entry for Polyprenol reductase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020497
Protein NamePolyprenol reductase
Uniport IdQ9H8P0
GeneSRD5A3
Gene Id79644
DomainSteroid_dh
Pfam PF02544  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00510 N-Glycan biosynthesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006702 androgen biosynthetic process
Biological Process GO:0019408 dolichol biosynthetic process
Biological Process GO:0006488 dolichol-linked oligosaccharide biosynthetic process
Biological Process GO:0019348 dolichol metabolic process
Biological Process GO:0006489 dolichyl diphosphate biosynthetic process
Biological Process GO:0016095 polyprenol catabolic process
molecular function GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity
molecular function GO:0047751 cholestenone 5-alpha-reductase activity
molecular function GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
molecular function GO:0102389 polyprenol reductase activity
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-193048 Androgen biosynthesis
R-HSA-196071 Metabolism of steroid hormones
R-HSA-3781865 Diseases of glycosylation
R-HSA-392499 Metabolism of proteins
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-446199 Synthesis of Dolichyl-phosphate
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis
R-HSA-4755579 Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ
R-HSA-556833 Metabolism of lipids
R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis
R-HSA-5668914 Diseases of metabolism
R-HSA-597592 Post-translational protein modification
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009363 BXGD000599 Congenital ocular coloboma (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0010038 BXGD000643 Corneal Opacity Eye Diseases
C0010495 BXGD000674 Cutis Laxa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0015393 BXGD000981 Eye Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0019214 BXGD001307 Hepatosplenomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Hemic and Lymphatic Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020555 BXGD001431 Hypertrichosis Skin and Connective Tissue Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0020796 BXGD001468 Profound Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0022336 BXGD001535 Creutzfeldt-Jakob disease Infections; Nervous System Diseases; Mental Disorders
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0025363 BXGD001867 Mental Retardation, Psychosocial Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0042798 BXGD003003 Low Vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0085576 BXGD003188 Iron-Refractory Iron Deficiency Anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0162834 BXGD003988 Hyperpigmentation Skin and Connective Tissue Diseases
C0206733 BXGD004278 Strawberry nevus of skin Neoplasms
C0221356 BXGD004448 Brachycephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0239234 BXGD004974 Low set ears
C0240063 BXGD005015 Coloboma of iris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0240538 BXGD005041 Convex nasal ridge
C0240543 BXGD005042 Bulbous nose
C0266464 BXGD005676 Polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266551 BXGD005693 Congenital coloboma of iris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0271561 BXGD006213 Somatotropin deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0272375 BXGD006359 Antithrombin III Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0282577 BXGD006816 Congenital Disorders of Glycosylation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0338502 BXGD007192 Hypoplasia of the optic nerve Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0376329 BXGD007989 New Variant Creutzfeldt-Jakob Disease Infections; Nervous System Diseases; Mental Disorders
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0409338 BXGD008381 Flexion contracture - elbow
C0424503 BXGD008532 Dysmorphic facies
C0432072 BXGD008718 Dysmorphic features
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0730290 BXGD009946 Cone Dystrophy Eye Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0751254 BXGD010366 Creutzfeldt-Jakob Disease, Familial Infections; Nervous System Diseases; Mental Disorders
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0917816 BXGD011419 Mental deficiency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C0948740 BXGD011550 Hypoplasia of the pituitary gland
C1184919 BXGD011799 Thoracic kyphosis Musculoskeletal Diseases
C1260926 BXGD011844 Abnormal pigmentation
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1298695 BXGD012251 Hypoplasia of optic disc Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1836542 BXGD014129 Depressed nasal bridge
C1837899 BXGD014285 Type I transferrin isoform profile
C1839630 BXGD014391 Severe muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1839739 BXGD014400 Thick lower lip vermilion
C1840379 BXGD014459 Cerebellar vermis hypoplasia
C1846149 BXGD014786 Intellectual disability, progressive Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1848701 BXGD014967 Elevated hepatic transaminase
C1849367 BXGD015046 Nasal bridge wide
C1854301 BXGD015391 Motor delay Mental Disorders
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1860834 BXGD016006 Infantile muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2675185 BXGD017276 Kahrizi Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C2749688 BXGD017633 Abnormal isoelectric focusing of serum transferrin
C2981150 BXGD018211 Uranostaphyloschisis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3277940 BXGD018725 Generalized hypertrichosis Skin and Connective Tissue Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386 BXGD019284 Abnormal vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3714796 BXGD019434 Isolated somatotropin deficiency
C3806179 BXGD019498 Spotty hyperpigmentation
C4022738 BXGD020974 Neurodevelopmental delay
C4025250 BXGD021605 Abnormal sacrum morphology
C4025712 BXGD021748 Abnormality of the cerebellar vermis
C4049796 BXGD021951 Abnormality of cardiovascular system morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4317224 BXGD022736 Congenital disorder of glycosylation type 1q Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4551563 BXGD023351 Microcephaly (physical finding)
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4553962 BXGD023553 Hyperkeratosis, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003611 Latex 416.57
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein