Showing entry for Serine/threonine-protein kinase Nek6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020528
Protein NameSerine/threonine-protein kinase Nek6
Uniport IdQ9HC98
GeneNEK6
Gene Id10783
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0051301 cell division
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0007077 mitotic nuclear envelope disassembly
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:2000772 regulation of cellular senescence
Biological Process GO:0007346 regulation of mitotic cell cycle
Biological Process GO:0030071 regulation of mitotic metaphase/anaphase transition
Biological Process GO:0051225 spindle assembly
molecular function GO:0033613 activating transcription factor binding
molecular function GO:0005524 ATP binding
molecular function GO:0019894 kinesin binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0001222 transcription corepressor binding
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0034451 centriolar satellite
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005874 microtubule
cellular component GO:0016607 nuclear speck
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
cellular component GO:0000922 spindle pole
Reactome
Pathway Id Pathway Name
R-HSA-1640170 Cell Cycle
R-HSA-2980766 Nuclear Envelope Breakdown
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-68875 Mitotic Prophase
R-HSA-68877 Mitotic Prometaphase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0027126 BXGD001976 Myotonic Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0031269 BXGD002297 Peutz-Jeghers Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Skin and Connective Tissue Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677936 BXGD009737 Refractory cancer Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3250443 BXGD018584 MYOTONIC DYSTROPHY 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000655 Harmalol 200.24
BXGC0000933 (-)-Arctigenin 372.41
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0001940 Daphnetin 178.14
BXGC0002071 Apigenin 270.24
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0007014 Harman 182.22
BXGC0007052 Olomoucine 298.34
BXGC0012352 Chelerythrine 348.12
BXGC0012706 4-hydroxy-5-nitrophenyl acetic acid 197.03
BXGC0013582 Curcumin 368.13
BXGC0020911 Debromohymenialdisine 245.09
BXGC0024554 D-luciferin 280
BXGC0034256 Rottlerin 516.18
BXGC0037070 Epicoccolide B 358.07
BXGC0042870 Piceatannol 244.07
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
BXGC0051873 Sl-0101 516.13
BXGC0051995 Wedelolactone 314.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein