Showing entry for MAP kinase-activated protein kinase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010680
Protein NameMAP kinase-activated protein kinase 2
Uniport IdP49137
GeneMAPKAPK2
Gene Id9261
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04218 Cellular senescence
3. Environmental Information Processing 3.2 Signal transduction hsa04370 VEGF signaling pathway
5. Organismal Systems 5.1 Immune system hsa04625 C-type lectin receptor signaling pathway
5. Organismal Systems 5.6 Nervous system hsa04722 Neurotrophin signaling pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05167 Kaposi sarcoma-associated herpesvirus infection
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0070935 3'-UTR-mediated mRNA stabilization
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0035924 cellular response to vascular endothelial growth factor stimulus
Biological Process GO:0006954 inflammatory response
Biological Process GO:0048839 inner ear development
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0006691 leukotriene metabolic process
Biological Process GO:0044351 macropinocytosis
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0038066 p38MAPK cascade
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:1900034 regulation of cellular response to heat
Biological Process GO:0032675 regulation of interleukin-6 production
Biological Process GO:0043488 regulation of mRNA stability
Biological Process GO:0032680 regulation of tumor necrosis factor production
Biological Process GO:0034097 response to cytokine
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0002224 toll-like receptor signaling pathway
Biological Process GO:0048010 vascular endothelial growth factor receptor signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0009931 calcium-dependent protein serine/threonine kinase activity
molecular function GO:0005516 calmodulin binding
molecular function GO:0051019 mitogen-activated protein kinase binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005813 centrosome
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-166520 Signaling by NTRKs
R-HSA-167044 Signalling to RAS
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-171007 p38MAPK events
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-187687 Signalling to ERKs
R-HSA-194138 Signaling by VEGF
R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
R-HSA-199920 CREB phosphorylation
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-2262752 Cellular responses to stress
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559583 Cellular Senescence
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-3371556 Cellular response to heat stress
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-450294 MAP kinase activation
R-HSA-450302 activated TAK1 mediates p38 MAPK activation
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
R-HSA-556833 Metabolism of lipids
R-HSA-8953854 Metabolism of RNA
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-8978868 Fatty acid metabolism
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0013238 BXGD000806 Dry Eye Syndromes Eye Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030809 BXGD002258 Pemphigus Vulgaris Skin and Connective Tissue Diseases; Immune System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0034155 BXGD002468 Purpura, Thrombotic Thrombocytopenic Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035235 BXGD002519 Respiratory Syncytial Virus Infections Infections
C0149678 BXGD003346 Epstein-Barr Virus Infections Infections
C0149745 BXGD003356 Oral Ulcer Stomatognathic Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0314719 BXGD006890 Dryness of eye Eye Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400877 BXGD008262 Postoperative ileus Digestive System Diseases
C0409952 BXGD008399 Idiopathic osteoarthritis Musculoskeletal Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0553694 BXGD009409 Oropharyngeal disorders Digestive System Diseases; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0699949 BXGD009872 airway disease Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0748355 BXGD010195 Acute respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0851887 BXGD010930 Adenoviral infections
C0860659 BXGD011240 Aloof
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1268935 BXGD011997 Congenital Thrombotic Thrombocytopenic Purpura Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1384584 BXGD012943 Generalized osteoarthritis Musculoskeletal Diseases
C1411966 BXGD013047 Clostridium; difficile (disorder)
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1868938 BXGD016542 End stage cardiac failure
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3544266 BXGD019113 Hepatobiliary cancer
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4324298 BXGD022755 Tumour inflammation
C4329280 BXGD022784 Advanced Head and Neck Carcinoma
C4725671 BXGD023833 High-Risk Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000655 Harmalol 200.24
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0002071 Apigenin 270.24
BXGC0002588 Magnesium 24.31
BXGC0003485 Naphthalen-1-ol 144.17
BXGC0004580 Carbanilide 212.25
BXGC0004705 Diphenylamine 169.22
BXGC0005683 Quercetin 302.24
BXGC0007014 Harman 182.22
BXGC0007029 Emodin 270.24
BXGC0012352 Chelerythrine 348.12
BXGC0023872 Adenine 135.05
BXGC0024554 D-luciferin 280
BXGC0034256 Rottlerin 516.18
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0051873 Sl-0101 516.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein