Showing entry for Rhodopsin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006725
Protein NameRhodopsin
Uniport IdP08100
GeneRHO
Gene Id6010
Domain7tm_1; Rhodopsin_N
Pfam PF00001   PF10413  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.7 Sensory system hsa04744 Phototransduction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0016038 absorption of visible light
Biological Process GO:0071482 cellular response to light stimulus
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0045494 photoreceptor cell maintenance
Biological Process GO:0007602 phototransduction
Biological Process GO:0007603 phototransduction, visible light
Biological Process GO:0018298 protein-chromophore linkage
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0022400 regulation of rhodopsin mediated signaling pathway
Biological Process GO:0060041 retina development in camera-type eye
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0016056 rhodopsin mediated signaling pathway
Biological Process GO:0007601 visual perception
molecular function GO:0005502 11-cis retinal binding
molecular function GO:0008020 G protein-coupled photoreceptor activity
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0046872 metal ion binding
cellular component GO:0005911 cell-cell junction
cellular component GO:0060170 ciliary membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0030660 Golgi-associated vesicle membrane
cellular component GO:0000139 Golgi membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0097381 photoreceptor disc membrane
cellular component GO:0001917 photoreceptor inner segment
cellular component GO:0060342 photoreceptor inner segment membrane
cellular component GO:0001750 photoreceptor outer segment
cellular component GO:0042622 photoreceptor outer segment membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-2187338 Visual phototransduction
R-HSA-2187338 Visual phototransduction
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-HSA-2485179 Activation of the phototransduction cascade
R-HSA-2485179 Activation of the phototransduction cascade
R-HSA-2514856 The phototransduction cascade
R-HSA-2514856 The phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-419771 Opsins
R-HSA-500792 GPCR ligand binding
R-HSA-5617833 Cilium Assembly
R-HSA-5617833 Cilium Assembly
R-HSA-5620916 VxPx cargo-targeting to cilium
R-HSA-5620916 VxPx cargo-targeting to cilium
R-HSA-5620920 Cargo trafficking to the periciliary membrane
R-HSA-5620920 Cargo trafficking to the periciliary membrane
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0008525 BXGD000554 Choroideremia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0012746 BXGD000787 Dissociative disorder Mental Disorders
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024440 BXGD001774 Macular Edema, Cystoid Eye Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0029128 BXGD002115 Optic Disk Drusen Eye Diseases; Nervous System Diseases
C0031941 BXGD002317 Pineal Gland Neoplasm Neoplasms; Nervous System Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0034951 BXGD002498 Refractive Errors Eye Diseases
C0035220 BXGD002512 Respiratory Distress Syndrome, Newborn Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0035305 BXGD002529 Retinal Detachment Eye Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035333 BXGD002538 Retinitis Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0036631 BXGD002626 Seminoma Neoplasms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151718 BXGD003464 Hypocholesterolemia Nutritional and Metabolic Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152191 BXGD003556 Scotoma, Central Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0152200 BXGD003557 Achromatopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0154832 BXGD003747 Exudative retinopathy Eye Diseases; Cardiovascular Diseases
C0154860 BXGD003752 Hereditary retinal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0154946 BXGD003759 Acute angle-closure glaucoma Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0162830 BXGD003987 Dermatitis, Phototoxic Skin and Connective Tissue Diseases
C0175694 BXGD004002 Smith-Lemli-Opitz Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206139 BXGD004159 Lichen Planus, Oral Skin and Connective Tissue Diseases; Stomatognathic Diseases
C0220620 BXGD004299 Gastrointestinal Carcinoid Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220701 BXGD004325 RETINITIS PIGMENTOSA 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0239119 BXGD004963 Lenticonus
C0240897 BXGD005060 Retinal exudates
C0241688 BXGD005107 Peripheral visual field loss
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0264716 BXGD005417 Chronic heart failure Cardiovascular Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0268425 BXGD005943 Alstrom Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0271093 BXGD006162 Stargardt's disease
C0271183 BXGD006169 Severe myopia Eye Diseases
C0278601 BXGD006547 Inflammatory Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0302129 BXGD006830 Achromatopsia 1 Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0311338 BXGD006878 Fundus Albipunctatus Eye Diseases
C0334070 BXGD006986 Maturation defect
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0339510 BXGD007257 Vitelliform Macular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0339525 BXGD007258 Autosomal dominant retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0339526 BXGD007259 Autosomal recessive retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0339535 BXGD007263 Night blindness, congenital stationary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0344232 BXGD007659 Blurred vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0423420 BXGD008483 Absent foveal reflex
C0423421 BXGD008484 Atrophic macular change
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0730285 BXGD009943 Diabetic macular edema Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0752166 BXGD010684 Bardet-Biedl Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1272174 BXGD012010 Scotopic sensitivity
C1285162 BXGD012167 Degenerative disorder Pathological Conditions, Signs and Symptoms
C1288283 BXGD012175 Atrophoderma maculatum Skin and Connective Tissue Diseases
C1298695 BXGD012251 Hypoplasia of optic disc Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1306122 BXGD012355 Oguchi disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1335059 BXGD012755 testicular nonseminoma
C1336708 BXGD012852 Testicular Germ Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C1405854 BXGD013028 Retinitis punctata albescens (disorder) Eye Diseases
C1411966 BXGD013047 Clostridium; difficile (disorder)
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1527358 BXGD013279 Phototoxicity Skin and Connective Tissue Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1836926 BXGD014179 Bone spicule pigmentation of the retina
C1839025 BXGD014353 Decreased light- and dark-adapted electroretinogram amplitude
C1839364 BXGD014371 Progressive visual loss
C1840077 BXGD014434 Anteverted nostril
C1842475 BXGD014520 Retinitis Pigmentosa 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1848172 BXGD014908 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1849367 BXGD015046 Nasal bridge wide
C1850362 BXGD015134 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1857644 BXGD015728 Retinal pigment epithelial mottling
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1864869 BXGD016263 Night Blindness, Congenital Stationary, Autosomal Dominant 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1864877 BXGD016267 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1865866 BXGD016345 Congenital sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1879328 BXGD016573 Blindness both eyes NOS (disorder) Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1998028 BXGD016865 Photoreceptor degeneration Eye Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2718001 BXGD017521 Protein Misfolding Disorders Nutritional and Metabolic Diseases
C2931258 BXGD017991 Amaurosis congenita of Leber, type 1 Eye Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3151001 BXGD018373 Retinitis Pigmentosa 4 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3151111 BXGD018397 Abnormal light- and dark-adapted electroretinogram
C3278975 BXGD018749 Attenuation of retinal blood vessels
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3495587 BXGD018996 Night Blindness, Congenital Stationary, Type 1A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3501847 BXGD019030 Night blindness, congenital stationary, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3551052 BXGD019144 Night blindness, stationary
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3711543 BXGD019396 X-Linked Csnb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3825718 BXGD019702 Retina--Diseases
C3887875 BXGD019923 Visual field defects Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4016366 BXGD020318 RETINITIS PIGMENTOSA 4, AUTOSOMAL RECESSIVE
C4021786 BXGD020779 Atypical scarring of skin Pathological Conditions, Signs and Symptoms
C4023678 BXGD021238 Monocular strabismus Eye Diseases; Nervous System Diseases
C4024756 BXGD021405 Abnormality of macular pigmentation
C4024760 BXGD021408 Progressive visual field defects
C4024762 BXGD021409 Pattern dystrophy of the retina Eye Diseases
C4024818 BXGD021428 Progressive night blindness Eye Diseases
C4041558 BXGD021877 Cone-rod synaptic disorder, congenital nonprogressive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4072872 BXGD022008 obsolete Rod-cone dystrophy
C4072991 BXGD022029 Yellow/white lesions of the retina
C4085590 BXGD022119 Cone-Rod Dystrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4087347 BXGD022144 Autosomal dominant cerebellar ataxia
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4280422 BXGD022380 Bilateral nanophthalmos
C4477018 BXGD022905 Sectoral retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4551633 BXGD023378 Pigmentary retinal dystrophy Eye Diseases
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4703439 BXGD023647 Abnormality of fundus pigmentation
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722277 BXGD023797 NEUROPATHY, CONGENITAL HYPOMYELINATING, 2
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002276 Hexadecanal 240.42
BXGC0005513 Hexadecanoic acid 256.42
BXGC0042373 N,N-Dimethyldodecan-1-Amine Oxide 229.24
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein