Showing entry for Carnitine O-palmitoyltransferase 2, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008906
Protein NameCarnitine O-palmitoyltransferase 2, mitochondrial
Uniport IdP23786
GeneCPT2
Gene Id1376
DomainCarn_acyltransf
Pfam PF00755  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00071 Fatty acid degradation
1. Metabolism 1.0 Global and overview maps hsa01212 Fatty acid metabolism
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006853 carnitine shuttle
Biological Process GO:0006635 fatty acid beta-oxidation
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0019216 regulation of lipid metabolic process
molecular function GO:0004095 carnitine O-palmitoyltransferase activity
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1989781 PPARA activates gene expression
R-HSA-200425 Carnitine metabolism
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002875 BXGD000135 Cooley's anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006112 BXGD000370 Brain Diseases, Metabolic Nutritional and Metabolic Diseases; Nervous System Diseases
C0006114 BXGD000371 Cerebral Edema Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009421 BXGD000608 Comatose Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0014378 BXGD000912 Enterovirus Infections Infections
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015674 BXGD001012 Chronic Fatigue Syndrome Infections; Musculoskeletal Diseases; Nervous System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0016506 BXGD001062 Foot Deformities Musculoskeletal Diseases
C0017921 BXGD001152 Glycogen storage disease type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0017924 BXGD001155 Glycogen Storage Disease Type V Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022638 BXGD001567 Ketosis Nutritional and Metabolic Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023380 BXGD001640 Lethargy Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027080 BXGD001969 Myoglobinuria Musculoskeletal Diseases
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027849 BXGD002049 Neuroleptic Malignant Syndrome Nervous System Diseases; Chemically-Induced Disorders
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0035410 BXGD002546 Rhabdomyolysis Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039239 BXGD002803 Sinus Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0154251 BXGD003710 Lipid Metabolism Disorders Nutritional and Metabolic Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162297 BXGD003932 Respiratory arrest Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Cardiovascular Diseases
C0162323 BXGD003937 Polyarthritis Musculoskeletal Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178417 BXGD004025 Anhedonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0220710 BXGD004329 Medium-chain acyl-coenzyme A dehydrogenase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0220994 BXGD004357 Hyperammonemia Pathological Conditions, Signs and Symptoms
C0221170 BXGD004400 Muscular stiffness Nervous System Diseases
C0221365 BXGD004452 Double ureter
C0231528 BXGD004496 Myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0236734 BXGD004823 Caffeine related disorders
C0239234 BXGD004974 Low set ears
C0239676 BXGD004989 High forehead
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0240543 BXGD005042 Bulbous nose
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0266464 BXGD005676 Polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0268238 BXGD005862 Triglyceride storage disease with ichthyosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0268596 BXGD006000 Multiple Acyl Coenzyme A Dehydrogenase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0270984 BXGD006149 Metabolic myopathy Musculoskeletal Diseases; Nervous System Diseases
C0311335 BXGD006877 Grand Mal Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0332615 BXGD006898 Myopathic facies
C0342751 BXGD007542 Generalized glycogen storage disease of infants Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0342788 BXGD007552 Renal carnitine transport defect Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C0342790 BXGD007553 Carnitine palmitoyl transferase 2 deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0409338 BXGD008381 Flexion contracture - elbow
C0410158 BXGD008408 Muscle damage
C0426886 BXGD008594 Tapering fingers (finding)
C0431478 BXGD008692 Posteriorly rotated ear
C0432072 BXGD008718 Dysmorphic features
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0542518 BXGD009278 Enlarged kidney
C0576093 BXGD009525 Knee joint valgus deformity Musculoskeletal Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0741494 BXGD010035 Elevated total bilirubin
C0750968 BXGD010267 Central Nervous System Metabolic Disorders Nutritional and Metabolic Diseases; Nervous System Diseases
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C0751743 BXGD010570 Metabolic Disorder, Central Nervous System, Acquired Nutritional and Metabolic Diseases; Nervous System Diseases
C0751744 BXGD010571 Brain Diseases, Metabolic, Acquired Nutritional and Metabolic Diseases; Nervous System Diseases
C0854530 BXGD011023 Infection by human herpesvirus 6 Infections
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1135773 BXGD011699 Acquired Metabolic Diseases, Nervous System Nutritional and Metabolic Diseases; Nervous System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306587 BXGD012368 Acute encephalopathy Nervous System Diseases
C1398312 BXGD012999 Narrow palate
C1445957 BXGD013081 Serum total cholesterol measurement
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611743 BXGD013456 Familial (FPAH)
C1696466 BXGD013502 Hepatic calcification
C1827524 BXGD013773 Wide spaced nipples
C1829703 BXGD013792 Carnitine palmitoyl transferase 1A deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1833508 BXGD013930 CARNITINE PALMITOYLTRANSFERASE II DEFICIENCY, LATE-ONSET Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C1833511 BXGD013931 CARNITINE PALMITOYLTRANSFERASE II DEFICIENCY, INFANTILE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases
C1833518 BXGD013932 CARNITINE PALMITOYLTRANSFERASE II DEFICIENCY, LETHAL NEONATAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1836923 BXGD014178 Gastrointestinal dysmotility
C1837246 BXGD014208 Intracerebral periventricular calcifications
C1837247 BXGD014209 Antenatal intracerebral hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C1837251 BXGD014211 Basal ganglia cysts
C1837256 BXGD014212 Macrovesicular hepatic steatosis Digestive System Diseases
C1837260 BXGD014214 Prominent forehead
C1837262 BXGD014215 Increased muscle lipid content
C1837273 BXGD014216 Long-chain dicarboxylic aciduria
C1837279 BXGD014217 Hypoplastic toenails
C1837731 BXGD014260 Overfolded helix
C1844577 BXGD014647 Hyperextensibility of the finger joints
C1848701 BXGD014967 Elevated hepatic transaminase
C1855020 BXGD015451 Acute necrotizing encephalopathy
C1856438 BXGD015606 Hypoketotic hypoglycemia Nutritional and Metabolic Diseases
C1856877 BXGD015648 Hyperextensible hand joints
C1857679 BXGD015735 Sloping forehead
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858430 BXGD015792 Death in infancy
C1865292 BXGD016306 Nonketotic hypoglycemia Nutritional and Metabolic Diseases
C1881170 BXGD016583 Inappropriate sinus tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1969443 BXGD016778 Trifunctional Protein Deficiency With Myopathy And Neuropathy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2267233 BXGD017017 Neonatal Hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2674608 BXGD017250 Feeding difficulties in infancy
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2718017 BXGD017522 TDP-43 Proteinopathies Nutritional and Metabolic Diseases; Nervous System Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3150613 BXGD018311 Long toe
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3280160 BXGD018810 ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 4
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3714581 BXGD019415 Multicystic Dysplastic Kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3854173 BXGD019824 Pre-renal acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3887523 BXGD019891 Very long chain acyl-CoA dehydrogenase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C4015009 BXGD020177 Decreased plasma free carnitine
C4021167 BXGD020572 Tapered toe
C4022810 BXGD021005 Abnormality of nervous system morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4023117 BXGD021114 Decreased plasma total carnitine
C4023808 BXGD021268 Hyperextensibility at elbow
C4529962 BXGD023178 Fatty Liver Disease
C4706387 BXGD023690 Acute necrotizing encephalopathy of childhood
C4707658 BXGD023720 Acute encephalopathy with biphasic seizures and late reduced diffusion Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0039601 Levocarnitine 161.11
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein