Showing entry for Peroxisomal targeting signal 1 receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010808
Protein NamePeroxisomal targeting signal 1 receptor
Uniport IdP50542
GenePEX5
Gene Id5830
DomainTPR_16; TPR_8
Pfam PF13181  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04146 Peroxisome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031333 negative regulation of protein-containing complex assembly
Biological Process GO:0016558 protein import into peroxisome matrix
Biological Process GO:0016560 protein import into peroxisome matrix, docking
Biological Process GO:0016561 protein import into peroxisome matrix, translocation
Biological Process GO:0045046 protein import into peroxisome membrane
Biological Process GO:0006625 protein targeting to peroxisome
Biological Process GO:0051262 protein tetramerization
Biological Process GO:0016567 protein ubiquitination
molecular function GO:0019899 enzyme binding
molecular function GO:0005052 peroxisome matrix targeting signal-1 binding
molecular function GO:0033328 peroxisome membrane targeting sequence binding
molecular function GO:0000268 peroxisome targeting sequence binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0047485 protein N-terminus binding
molecular function GO:0140311 protein sequestering activity
molecular function GO:0031267 small GTPase binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016020 membrane
cellular component GO:0005782 peroxisomal matrix
cellular component GO:0005778 peroxisomal membrane
cellular component GO:0005777 peroxisome
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-1632852 Macroautophagy
R-HSA-9612973 Autophagy
R-HSA-9663891 Selective autophagy
R-HSA-9664873 Pexophagy
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001403 BXGD000048 Addison Disease Immune System Diseases; Endocrine System Diseases
C0001623 BXGD000066 Adrenal gland hypofunction Endocrine System Diseases
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009691 BXGD000622 Congenital cataract Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Nervous System Diseases
C0010038 BXGD000643 Corneal Opacity Eye Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014877 BXGD000967 Esotropia Eye Diseases; Nervous System Diseases
C0015469 BXGD000996 Facial paralysis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0029422 BXGD002142 Osteochondrodysplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0030044 BXGD002186 Acrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0034194 BXGD002472 Pyloric Stenosis Digestive System Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0039239 BXGD002803 Sinus Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0043459 BXGD003048 Zellweger Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0156394 BXGD003856 Hypertrophy of clitoris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0158113 BXGD003875 Contracture of joint of hand Musculoskeletal Diseases
C0158465 BXGD003887 Acquired cubitus valgus
C0162285 BXGD003928 Edema of eyelid Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases; Cardiovascular Diseases
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0221358 BXGD004450 Long narrow head
C0221369 BXGD004453 Acquired Camptodactyly
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235095 BXGD004723 Visual field constriction Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0238621 BXGD004947 Aminoaciduria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0239138 BXGD004966 Hip joint varus deformity - observation Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0239234 BXGD004974 Low set ears
C0239676 BXGD004989 High forehead
C0240421 BXGD005037 Progressive muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0266464 BXGD005676 Polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266589 BXGD005698 Congenital ear anomaly NOS (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Otorhinolaryngologic Diseases
C0271386 BXGD006194 Vertical Nystagmus Eye Diseases; Nervous System Diseases
C0282525 BXGD006809 Adrenoleukodystrophy, Neonatal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0282527 BXGD006811 Infantile Refsum Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0282528 BXGD006812 Peroxisomal Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0282529 BXGD006813 Chondrodysplasia Punctata, Rhizomelic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0349588 BXGD007933 Short stature
C0410528 BXGD008430 Skeletal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0423109 BXGD008470 Upward slant of palpebral fissure
C0423250 BXGD008476 Corneal stromal opacities Eye Diseases
C0424503 BXGD008532 Dysmorphic facies
C0424731 BXGD008542 Single transverse palmar crease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0456070 BXGD008863 Growth delay
C0456132 BXGD008869 Large fontanelle
C0524582 BXGD009231 Mulibrey Nanism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0546967 BXGD009349 Posterior embryotoxon Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0557874 BXGD009444 Global developmental delay
C0595921 BXGD009626 Intraocular pressure disorder Eye Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0685409 BXGD009810 Congenital Camptodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0685891 BXGD009824 Congenital hypoplasia of thymus Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0856863 BXGD011122 Broad-based gait
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0878638 BXGD011378 Abnormality of the tongue
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1303007 BXGD012319 Brushfield spots
C1389113 BXGD012965 Generalized amyotrophy
C1832200 BXGD013810 Peroxisome biogenesis disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1836184 BXGD014088 Short femoral neck
C1836542 BXGD014129 Depressed nasal bridge
C1836830 BXGD014165 Developmental regression Mental Disorders
C1836940 BXGD014182 Thickened nuchal skin fold
C1837082 BXGD014194 Metaphyseal cupping
C1837142 BXGD014201 Poor suck
C1837249 BXGD014210 Malformations of Cortical Development, Group II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1837260 BXGD014214 Prominent forehead
C1837397 BXGD014227 Severe global developmental delay
C1837402 BXGD014228 Flat occiput
C1837404 BXGD014229 High, narrow palate
C1838662 BXGD014334 Metaphyseal irregularity
C1839630 BXGD014391 Severe muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1840077 BXGD014434 Anteverted nostril
C1843392 BXGD014582 Death in childhood
C1846460 BXGD014820 Abnormality of the outer ear
C1846821 BXGD014841 Abnormality of coagulation
C1849367 BXGD015046 Nasal bridge wide
C1853241 BXGD015321 Flat face
C1856660 BXGD015629 Abnormality of the helix
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1857790 BXGD015748 Thoracic scoliosis Musculoskeletal Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858430 BXGD015792 Death in infancy
C1859126 BXGD015854 Stippled epiphyses
C1859133 BXGD015855 RHIZOMELIC CHONDRODYSPLASIA PUNCTATA, TYPE 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C1859235 BXGD015866 Intrahepatic biliary dysgenesis
C1861869 BXGD016088 Underdeveloped supraorbital ridges
C1862095 BXGD016100 Bilateral single transverse palmar creases
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1866134 BXGD016378 Wide anterior fontanel
C1866934 BXGD016427 Reduced tendon reflexes Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1963165 BXGD016685 Malabsorption, CTCAE
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2025392 BXGD016883 Polar cataract Eye Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2674608 BXGD017250 Feeding difficulties in infancy
C2676026 BXGD017321 Optic nerve dysplasia
C2919142 BXGD017867 Short Stature, CTCAE
C3279397 BXGD018755 Very long chain fatty acid accumulation
C3550234 BXGD019133 PEROXISOME BIOGENESIS DISORDER 2B Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3550273 BXGD019134 PEROXISOME BIOGENESIS DISORDER 2A (ZELLWEGER) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3550693 BXGD019136 PEROXISOME BIOGENESIS DISORDER 3B Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3553450 BXGD019175 Profound global developmental delay
C3658299 BXGD019258 Zellweger Spectrum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714581 BXGD019415 Multicystic Dysplastic Kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3714745 BXGD019427 Malabsorption Digestive System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021611 BXGD020697 Abnormality of epiphysis morphology
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4021780 BXGD020775 Abnormality of the liver
C4021815 BXGD020801 Abnormal palate morphology
C4023042 BXGD021081 Abnormality of the mitochondrion
C4023786 BXGD021261 Elevated levels of phytanic acid
C4025679 BXGD021728 Stippled chondral calcification
C4025844 BXGD021824 Abnormal chorioretinal morphology
C4049796 BXGD021951 Abnormality of cardiovascular system morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4082169 BXGD022084 Metatarsus Varus Musculoskeletal Diseases
C4225237 BXGD022185 RHIZOMELIC CHONDRODYSPLASIA PUNCTATA, TYPE 5
C4551563 BXGD023351 Microcephaly (physical finding)
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4553743 BXGD023548 Spasticity, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4721541 BXGD023753 PEROXISOME BIOGENESIS DISORDER 1A (ZELLWEGER) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002708 Strontium 87.62
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein