Showing entry for Phosphatidylinositol polyphosphate 5-phosphatase type IV


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021193
Protein NamePhosphatidylinositol polyphosphate 5-phosphatase type IV
Uniport IdQ9NRR6
GeneINPP5E
Gene Id56623
DomainExo_endo_phos
Pfam PF03372  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00562 Inositol phosphate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046855 inositol phosphate dephosphorylation
Biological Process GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:1903565 negative regulation of protein localization to cilium
Biological Process GO:0017148 negative regulation of translation
Biological Process GO:0006661 phosphatidylinositol biosynthetic process
Biological Process GO:0046856 phosphatidylinositol dephosphorylation
molecular function GO:0004445 inositol-polyphosphate 5-phosphatase activity
molecular function GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
molecular function GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
cellular component GO:0005930 axoneme
cellular component GO:0005929 cilium
cellular component GO:0005829 cytosol
cellular component GO:0032580 Golgi cisterna membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0001726 ruffle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-556833 Metabolism of lipids
R-HSA-5617833 Cilium Assembly
R-HSA-5620920 Cargo trafficking to the periciliary membrane
R-HSA-5624958 ARL13B-mediated ciliary trafficking of INPP5E
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0008780 BXGD000571 Ciliary Motility Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009714 BXGD000624 Hepatic Fibrosis, Congenital Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0011813 BXGD000748 Dextrocardia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0014065 BXGD000884 Congenital cerebral hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014067 BXGD000885 Occipital Encephalocele Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0015398 BXGD000984 Eye Diseases, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0016506 BXGD001062 Foot Deformities Musculoskeletal Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020541 BXGD001424 Portal Hypertension Digestive System Diseases
C0020796 BXGD001468 Profound Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022679 BXGD001575 Cystic kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024421 BXGD001770 Macroglossia Stomatognathic Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025363 BXGD001867 Mental Retardation, Psychosocial Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028860 BXGD002093 Oculocerebrorenal Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
C0030846 BXGD002260 Penile Diseases Male Urogenital Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033785 BXGD002421 Pseudarthrosis Wounds and Injuries
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0086543 BXGD003294 Cataract Eye Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152427 BXGD003590 Polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0155299 BXGD003783 Coloboma of optic disc Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0158733 BXGD003903 Hand polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0158734 BXGD003904 Polydactyly of toes Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0234649 BXGD004692 Abnormal saccadic eye movement
C0239234 BXGD004974 Low set ears
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0240063 BXGD005015 Coloboma of iris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0240896 BXGD005059 Fundus coloboma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0241442 BXGD005099 Protrusion of tongue
C0265677 BXGD005564 Congenital hemivertebra Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266464 BXGD005676 Polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266551 BXGD005693 Congenital coloboma of iris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0271270 BXGD006178 Oculovestibuloauditory syndrome Eye Diseases; Nervous System Diseases; Cardiovascular Diseases
C0278152 BXGD006503 Hemifacial Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0345375 BXGD007730 Congenital hypoplasia of femur Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0345394 BXGD007733 Hypoplasia of spine Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0410528 BXGD008430 Skeletal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0431399 BXGD008684 Familial aplasia of the vermis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Male Urogenital Diseases
C0431904 BXGD008713 Ulnar polydactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0432163 BXGD008729 Defect of vertebral segmentation Musculoskeletal Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0520680 BXGD009102 Sleep Apnea, Central Respiratory Tract Diseases; Nervous System Diseases
C0543874 BXGD009299 Apraxia, oculomotor, Cogan type Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms; Cardiovascular Diseases
C0557874 BXGD009444 Global developmental delay
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0746102 BXGD010136 Chronic lung disease Respiratory Tract Diseases
C0752166 BXGD010684 Bardet-Biedl Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C0917816 BXGD011419 Mental deficiency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1567435 BXGD013413 Polycystic Kidney - body part Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1832471 BXGD013848 Renal dysplasia diffuse cystic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1834129 BXGD013957 Abnormal vertebral morphology
C1836047 BXGD014074 Long face
C1836393 BXGD014112 Abnormality of ocular smooth pursuit
C1837249 BXGD014210 Malformations of Cortical Development, Group II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1837260 BXGD014214 Prominent forehead
C1837458 BXGD014233 Impaired smooth pursuit
C1839326 BXGD014367 Abnormal form of the vertebral bodies
C1840077 BXGD014434 Anteverted nostril
C1840379 BXGD014459 Cerebellar vermis hypoplasia
C1842688 BXGD014532 Hypoplasia of the brainstem
C1848701 BXGD014967 Elevated hepatic transaminase
C1854113 BXGD015382 Prominent nasal bridge
C1854418 BXGD015402 Biparietal narrowing
C1855284 BXGD015482 Intrahepatic biliary atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C1855677 BXGD015529 Brainstem dysplasia
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1857662 BXGD015733 COACH syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Eye Diseases; Nervous System Diseases
C1857802 BXGD015750 MORM syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Male Urogenital Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859292 BXGD015869 Triangular-shaped open mouth
C1859846 BXGD015936 Childhood-onset truncal obesity
C1861866 BXGD016087 Aplasia/Hypoplasia of the corpus callosum
C1865060 BXGD016292 Molar tooth sign on MRI
C1868571 BXGD016508 Highly arched eyebrow
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2112942 BXGD016923 Preaxial foot polydactyly
C2674608 BXGD017250 Feeding difficulties in infancy
C2936476 BXGD018123 Chronic Liver Failure Digestive System Diseases
C2981150 BXGD018211 Uranostaphyloschisis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3279222 BXGD018751 Aplasia/Hypoplasia of the cerebellum
C3489733 BXGD018945 Oculomotor apraxia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms; Cardiovascular Diseases
C3540764 BXGD019092 Coloboma of the Retina Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386 BXGD019284 Abnormal vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714506 BXGD019407 Meckel syndrome type 1 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Male Urogenital Diseases; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C3714581 BXGD019415 Multicystic Dysplastic Kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3806216 BXGD019499 Neonatal breathing dysregulation
C3806218 BXGD019500 Episodic tachypnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C3810214 BXGD019643 Elongated superior cerebellar peduncle
C3887499 BXGD019884 Renal cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4020922 BXGD020500 Enlarged fossa interpeduncularis
C4021813 BXGD020799 Oral cleft
C4021862 BXGD020821 Absent epiphyses
C4025010 BXGD021525 Coat hanger sign of ribs
C4025719 BXGD021754 Dysgenesis of the cerebellar vermis
C4025819 BXGD021808 Abnormality of the hypothalamus-pituitary axis
C4274118 BXGD022347 Joubert syndrome with ocular defect Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Male Urogenital Diseases
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4551493 BXGD023318 Situs inversus totalis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4551560 BXGD023349 Truncal obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C4551568 BXGD023356 Joubert syndrome 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Male Urogenital Diseases
C4551720 BXGD023400 Primary Ciliary Dyskinesia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552000 BXGD023473 Episodic Kinesigenic Dyskinesia 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein