Showing entry for Serine/threonine-protein kinase Nek1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019712
Protein NameSerine/threonine-protein kinase Nek1
Uniport IdQ96PY6
GeneNEK1
Gene Id4750
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007049 cell cycle
Biological Process GO:0051301 cell division
Biological Process GO:0060271 cilium assembly
Biological Process GO:0042769 DNA damage response, detection of DNA damage
Biological Process GO:0006468 protein phosphorylation
molecular function GO:0071889 14-3-3 protein binding
molecular function GO:0005524 ATP binding
molecular function GO:0016301 kinase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0004713 protein tyrosine kinase activity
cellular component GO:0034451 centriolar satellite
cellular component GO:0005813 centrosome
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0000242 pericentriolar material
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011813 BXGD000748 Dextrocardia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020305 BXGD001374 Hydrops Fetalis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0020490 BXGD001403 Hyperopia Eye Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023066 BXGD001605 Laryngospasm Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0024507 BXGD001779 Majewski Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026363 BXGD001901 Mohr Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0026707 BXGD001922 Mucopolysaccharidosis IV Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027443 BXGD001992 Natal Teeth
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0029422 BXGD002142 Osteochondrodysplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036069 BXGD002573 Saldino-Noonan Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036996 BXGD002655 Short Rib-Polydactyly Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042454 BXGD002983 Velopharyngeal Insufficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0043352 BXGD003045 Xerostomia Stomatognathic Diseases
C0078981 BXGD003059 Arachnoid Cysts Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0085548 BXGD003183 Autosomal Recessive Polycystic Kidney Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085633 BXGD003216 Mood swings Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152427 BXGD003590 Polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221352 BXGD004444 Syndactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0231835 BXGD004527 Tachypnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0235357 BXGD004742 Hypoplasia of teeth Digestive System Diseases; Stomatognathic Diseases
C0238591 BXGD004946 Adactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0241438 BXGD005098 Tongue nodules
C0265610 BXGD005555 Clinodactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0265783 BXGD005575 Congenital hypoplasia of lung Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0266039 BXGD005612 Taurodontism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0266111 BXGD005620 Bifid tongue Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266362 BXGD005657 Ambiguous Genitalia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0270790 BXGD006105 Quadriparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0277959 BXGD006487 Coarse hair
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0345958 BXGD007751 Large cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0393554 BXGD008087 Amyotrophic Lateral Sclerosis With Dementia Nutritional and Metabolic Diseases; Nervous System Diseases
C0399357 BXGD008237 Talon cusp
C0423113 BXGD008473 Telecanthus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0426790 BXGD008577 Narrow thorax
C0426805 BXGD008580 Hooked clavicle
C0426817 BXGD008585 Short ribs
C0431565 BXGD008695 Hamartoma of tongue Neoplasms; Stomatognathic Diseases
C0431904 BXGD008713 Ulnar polydactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0432197 BXGD008733 Short rib-polydactyly syndrome, Verma-Naumoff type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0432198 BXGD008734 Short rib-polydactyly syndrome, Beemer type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0522224 BXGD009198 Paralysed Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0541794 BXGD009262 Skeletal muscle atrophy
C0543859 BXGD009298 Amyotrophic Lateral Sclerosis, Guam Form Nutritional and Metabolic Diseases; Nervous System Diseases
C0549306 BXGD009368 Mesomelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0557874 BXGD009444 Global developmental delay
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0746674 BXGD010147 Generalized muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0878659 BXGD011380 Disproportionate short stature Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1389016 BXGD012962 ATRIOVENTRICULAR CANAL DEFECT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1395852 BXGD012991 Polydactyly preaxial type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1396772 BXGD012994 Hypoplasia of the epiglottis
C1406921 BXGD013032 Thoracic dysplasia
C1849367 BXGD015046 Nasal bridge wide
C1850256 BXGD015124 Median cleft lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C1852534 BXGD015289 Hypoplastic male external genitalia
C1855000 BXGD015448 Agenesis of central incisor
C1855277 BXGD015481 Shortening of the tibia
C1855285 BXGD015483 Protruding ear
C1855899 BXGD015558 Broad first metatarsal
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859480 BXGD015899 Cone-shaped epiphyses of the phalanges of the hand
C1860834 BXGD016006 Infantile muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1861373 BXGD016040 Y-shaped metacarpals
C1864785 BXGD016249 Normal kidneys
C1865695 BXGD016338 Spondylometaphyseal dysplasia, axial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1867131 BXGD016440 Broad hallux
C1963060 BXGD016679 Agitation, CTCAE 3.0
C1969178 BXGD016763 Mesomelic leg shortening
C2919142 BXGD017867 Short Stature, CTCAE
C2931889 BXGD018090 Oral-facial-digital syndrome, type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C3536734 BXGD019071 Hypoplastic pelvis
C3806510 BXGD019515 Horizontal ribs
C3806516 BXGD019517 Disproportionate shortening of the tibia
C4021336 BXGD020611 Complete duplication of hallux phalanx
C4021569 BXGD020677 Central retinal vessel vascular tortuosity
C4021618 BXGD020698 Polysyndactyly of hallux
C4021816 BXGD020802 Abnormality of the gingiva
C4021824 BXGD020809 Postaxial polysyndactyly of foot
C4022587 BXGD020928 Fatigable weakness of respiratory muscles
C4022588 BXGD020929 Fatigable weakness of swallowing muscles
C4023175 BXGD021136 Submucous cleft soft palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C4025060 BXGD021538 Peg-shaped maxillary lateral incisors
C4025881 BXGD021842 Abnormal oral frenulum morphology
C4073184 BXGD022062 Thick hair
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4315130 BXGD022694 Hippocampal atrophy
C4477070 BXGD022915 Unilateral alveolar cleft of maxilla
C4551856 BXGD023423 Asphyxiating Thoracic Dystrophy 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C4552811 BXGD023526 Generalized Muscle Weakness, CTCAE
C4552855 BXGD023528 Agitation, CTCAE 5.0
C4553743 BXGD023548 Spasticity, CTCAE
C4693523 BXGD023602 AMYOTROPHIC LATERAL SCLEROSIS, SUSCEPTIBILITY TO, 24
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein