Showing entry for Vasopressin V2 receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009428
Protein NameVasopressin V2 receptor
Uniport IdP30518
GeneAVPR2
Gene Id554
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.5 Excretory system hsa04962 Vasopressin-regulated water reabsorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007190 activation of adenylate cyclase activity
Biological Process GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Process GO:0007588 excretion
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007599 hemostasis
Biological Process GO:0007249 I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0032609 interferon-gamma production
Biological Process GO:0061024 membrane organization
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0035814 negative regulation of renal sodium excretion
Biological Process GO:0035811 negative regulation of urine volume
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0031398 positive regulation of protein ubiquitination
Biological Process GO:0003084 positive regulation of systemic arterial blood pressure
Biological Process GO:0045907 positive regulation of vasoconstriction
Biological Process GO:0001992 regulation of systemic arterial blood pressure by vasopressin
Biological Process GO:0003091 renal water homeostasis
Biological Process GO:0034097 response to cytokine
Biological Process GO:0021537 telencephalon development
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0042277 peptide binding
molecular function GO:0005000 vasopressin receptor activity
cellular component GO:0030665 clathrin-coated vesicle membrane
cellular component GO:0030139 endocytic vesicle
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005768 endosome
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-199991 Membrane Trafficking
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-382551 Transport of small molecules
R-HSA-388396 GPCR downstream signalling
R-HSA-388479 Vasopressin-like receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-445717 Aquaporin-mediated transport
R-HSA-500792 GPCR ligand binding
R-HSA-5619102 SLC transporter disorders
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9036092 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664433 Leishmania parasite growth and survival
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001624 BXGD000067 Adrenal Gland Neoplasms Neoplasms; Endocrine System Diseases
C0001627 BXGD000068 Congenital adrenal hyperplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007859 BXGD000494 Neck Pain Pathological Conditions, Signs and Symptoms
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011848 BXGD000750 Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014394 BXGD000914 Enuresis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0018273 BXGD001189 Growth Disorders Pathological Conditions, Signs and Symptoms
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020224 BXGD001366 Polyhydramnios Female Urogenital Diseases and Pregnancy Complications
C0020488 BXGD001402 Hypernatremia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020625 BXGD001451 Hyponatremia Nutritional and Metabolic Diseases
C0021141 BXGD001485 Inappropriate ADH Syndrome Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0022679 BXGD001575 Cystic kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028961 BXGD002102 Oliguria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029134 BXGD002118 Optic Neuritis Eye Diseases; Nervous System Diseases
C0029442 BXGD002151 Osteomalacia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Endocrine System Diseases
C0029866 BXGD002174 Other ureteric obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032617 BXGD002367 Polyuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0033141 BXGD002400 Cardiomyopathies, Primary Cardiovascular Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036529 BXGD002624 Myocardial Diseases, Secondary Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0043116 BXGD003028 HMN (Hereditary Motor Neuropathy) Proximal Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085548 BXGD003183 Autosomal Recessive Polycystic Kidney Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085602 BXGD003199 Polydipsia Pathological Conditions, Signs and Symptoms
C0162283 BXGD003927 Nephrogenic Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0232466 BXGD004543 Feeding difficulties
C0232831 BXGD004564 Impairment of urinary concentration Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0239377 BXGD004980 Arm Pain Pathological Conditions, Signs and Symptoms
C0242528 BXGD005176 Azotemia Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0265216 BXGD005466 X-linked hydrocephalus syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0265259 BXGD005487 Popliteal pterygium syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Musculoskeletal Diseases; Male Urogenital Diseases; Stomatognathic Diseases
C0268443 BXGD005947 Acquired Nephrogenic Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0270327 BXGD006074 Bedwetting Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0428282 BXGD008624 Serum creatinine low
C0432072 BXGD008718 Dysmorphic features
C0477633 BXGD009006 Cervical disc disorder Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0521620 BXGD009150 Dilatation of ureter Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0546884 BXGD009345 Hypovolemia Pathological Conditions, Signs and Symptoms
C0554309 BXGD009424 Prerenal uremia syndrome Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0557874 BXGD009444 Global developmental delay
C0558489 BXGD009456 Renal pain Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677501 BXGD009718 Congenital Nephrogenic Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0687120 BXGD009837 Nephronophthisis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0687720 BXGD009844 Central Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0700594 BXGD009894 Radiculopathy Nervous System Diseases
C0745744 BXGD010133 End Stage Liver Disease Digestive System Diseases
C0857122 BXGD011138 Hyponatraemic
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0878787 BXGD011392 Growth failure
C1112601 BXGD011679 Hypertonic dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C1290145 BXGD012180 Disorder of cervical spine Musculoskeletal Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1456687 BXGD013122 Polio and Post-Polio Syndrome Infections
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1563705 BXGD013386 Nephrogenic Diabetes Insipidus, Type I Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1563706 BXGD013387 Nephrogenic Diabetes Insipidus, Type II Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611743 BXGD013456 Familial (FPAH)
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1704375 BXGD013551 Hypophosphatemic Rickets Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C1840374 BXGD014456 Elevated systolic blood pressure Cardiovascular Diseases
C1844662 BXGD014655 Unexplained fevers Pathological Conditions, Signs and Symptoms
C1845202 BXGD014726 Nephrogenic Syndrome of Inappropriate Antidiuresis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C1845206 BXGD014727 Decreased circulating renin level
C1845977 BXGD014769 X- linked recessive
C1849265 BXGD015028 Overgrowth
C1850544 BXGD015150 Hypernatremic dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C1855106 BXGD015459 Neonatal onset
C1855311 BXGD015486 Megacystis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1859722 BXGD015925 Arthrogryposis, renal dysfunction, and cholestasis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2674608 BXGD017250 Feeding difficulties in infancy
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2712711 BXGD017488 Benign endometrial hyperplasia Female Urogenital Diseases and Pregnancy Complications
C2828000 BXGD017801 X-Linked Inherited Disorder Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C2919142 BXGD017867 Short Stature, CTCAE
C2931852 BXGD018079 Clear-cell metastatic renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3494970 BXGD018976 Idiopathic urethral stricture
C3536983 BXGD019078 Familial Hypophosphatemic Rickets Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases
C3536984 BXGD019079 Vitamin D-Resistant Rickets, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases
C3540852 BXGD019094 Rickets, X-Linked Hypophosphatemic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases
C3542500 BXGD019105 ADH-Resistant Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3671887 BXGD019330 Hypernatriuria
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3875046 BXGD019871 Partial nephrogenic diabetes insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3887650 BXGD019911 Adult Rickets Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C3888890 BXGD019989 Polyuria-polydipsia syndrome
C4021790 BXGD020782 Abnormality of the skeletal system
C4527149 BXGD023152 Intermediate Atypical Prostate Carcinoma
C4551984 BXGD023464 Arthrogryposis with renal dysfunction and cholestasis syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4552000 BXGD023473 Episodic Kinesigenic Dyskinesia 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4552810 BXGD023525 Irritability, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000982 L-Homocysteine 135.19
BXGC0005683 Quercetin 302.24
BXGC0005874 Racemethionine 149.21
BXGC0006183 L-Cystine 240.3
BXGC0037795 Cyclopamine 411.31
BXGC0038837 Pseudohypericin 520.08
BXGC0042462 Cysteine 121.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein