protein

Showing entry for NADH-ubiquinone oxidoreductase chain 1

General Target Information
BXGT Id	BXGT006108
Protein Name	NADH-ubiquinone oxidoreductase chain 1
Uniport Id	P03886
Gene	MT-ND1
Gene Id	4535
Domain	NADHdh
Pfam	PF00146
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
1. Metabolism	1.2 Energy metabolism	hsa00190	Oxidative phosphorylation
1. Metabolism	1.0 Global and overview maps	hsa01100	Metabolic pathways
5. Organismal Systems	5.10 Environmental adaptation	hsa04714	Thermogenesis
5. Organismal Systems	5.6 Nervous system	hsa04723	Retrograde endocannabinoid signaling
6. Human Diseases	6.4 Neurodegenerative diseases	hsa05012	Parkinson disease

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0009060	aerobic respiration
Biological Process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
Biological Process	GO:0032981	mitochondrial respiratory chain complex I assembly
Biological Process	GO:0042493	response to drug
Biological Process	GO:0033194	response to hydroperoxide
Biological Process	GO:0014070	response to organic cyclic compound
molecular function	GO:0008137	NADH dehydrogenase (ubiquinone) activity
cellular component	GO:0030425	dendrite
cellular component	GO:0016021	integral component of membrane
cellular component	GO:0005743	mitochondrial inner membrane
cellular component	GO:0031966	mitochondrial membrane
cellular component	GO:0005747	mitochondrial respiratory chain complex I
cellular component	GO:0043025	neuronal cell body

Reactome

Pathway Id	Pathway Name
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728	Metabolism
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
R-HSA-611105	Respiratory electron transport
R-HSA-6799198	Complex I biogenesis

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0000737	BXGD000005	Abdominal Pain	Pathological Conditions, Signs and Symptoms
C0001125	BXGD000024	Acidosis, Lactic	Nutritional and Metabolic Diseases
C0001403	BXGD000048	Addison Disease	Immune System Diseases; Endocrine System Diseases
C0002152	BXGD000104	Alloxan Diabetes	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0003123	BXGD000178	Anorexia	Pathological Conditions, Signs and Symptoms
C0003467	BXGD000194	Anxiety	Behavior and Behavior Mechanisms
C0003486	BXGD000197	Aortic Aneurysm	Cardiovascular Diseases
C0003537	BXGD000208	Aphasia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0003578	BXGD000211	Apnea	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0003811	BXGD000222	Cardiac Arrhythmia	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0003886	BXGD000238	Arthrogryposis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0004134	BXGD000256	Ataxia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352	BXGD000269	Autistic Disorder	Mental Disorders
C0005586	BXGD000315	Bipolar Disorder	Mental Disorders
C0005745	BXGD000331	Blepharoptosis	Eye Diseases
C0006625	BXGD000401	Cachexia	Pathological Conditions, Signs and Symptoms
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007193	BXGD000451	Cardiomyopathy, Dilated	Cardiovascular Diseases
C0007194	BXGD000452	Hypertrophic Cardiomyopathy	Cardiovascular Diseases
C0008489	BXGD000546	Chorea	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009024	BXGD000578	Clonus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009225	BXGD000594	Coenuriasis	Infections
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0009806	BXGD000633	Constipation	Pathological Conditions, Signs and Symptoms
C0010709	BXGD000689	Cyst	Pathological Conditions, Signs and Symptoms; Neoplasms
C0011168	BXGD000700	Deglutition Disorders	Digestive System Diseases; Otorhinolaryngologic Diseases
C0011334	BXGD000716	Dental caries	Stomatognathic Diseases
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853	BXGD000752	Diabetes Mellitus, Experimental	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336	BXGD000815	Dwarfism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013362	BXGD000817	Dysarthria	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013384	BXGD000826	Dyskinetic syndrome	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421	BXGD000837	Dystonia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015544	BXGD001003	Failure to Thrive	Pathological Conditions, Signs and Symptoms
C0015672	BXGD001011	Fatigue	Pathological Conditions, Signs and Symptoms
C0015930	BXGD001025	Fetal Distress	Pathological Conditions, Signs and Symptoms
C0015934	BXGD001026	Fetal Growth Retardation	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0015967	BXGD001030	Fever	Pathological Conditions, Signs and Symptoms
C0018021	BXGD001162	Goiter	Endocrine System Diseases
C0018524	BXGD001200	Hallucinations	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0018784	BXGD001220	Sensorineural Hearing Loss (disorder)	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018794	BXGD001222	Heart Block	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018802	BXGD001227	Congestive heart failure	Cardiovascular Diseases
C0018979	BXGD001260	Hemianopsia	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0018989	BXGD001263	Hemiparesis	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0019209	BXGD001305	Hepatomegaly	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020438	BXGD001382	Hypercalciuria	Pathological Conditions, Signs and Symptoms
C0020534	BXGD001421	Orbital separation excessive	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0020550	BXGD001429	Hyperthyroidism	Endocrine System Diseases
C0020578	BXGD001434	Hyperventilation	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0020615	BXGD001445	Hypoglycemia	Nutritional and Metabolic Diseases
C0020626	BXGD001452	Hypoparathyroidism	Endocrine System Diseases
C0020672	BXGD001461	Hypothermia, natural	Pathological Conditions, Signs and Symptoms
C0020676	BXGD001462	Hypothyroidism	Endocrine System Diseases
C0020757	BXGD001466	Ichthyoses	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0021843	BXGD001520	Intestinal Obstruction	Digestive System Diseases
C0022578	BXGD001557	Keratoconus	Eye Diseases
C0023264	BXGD001625	Leigh Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023380	BXGD001640	Lethargy	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0023520	BXGD001678	Leukodystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023976	BXGD001724	Long QT Syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0024408	BXGD001768	Machado-Joseph Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0024523	BXGD001781	Malabsorption Syndrome	Digestive System Diseases; Nutritional and Metabolic Diseases
C0025958	BXGD001882	Microcephaly	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026769	BXGD001930	Multiple Sclerosis	Immune System Diseases; Nervous System Diseases
C0026827	BXGD001936	Muscle hypotonia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838	BXGD001938	Muscle Spasticity	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026848	BXGD001941	Myopathy	Musculoskeletal Diseases; Nervous System Diseases
C0027498	BXGD001994	Nausea and vomiting	Pathological Conditions, Signs and Symptoms
C0027726	BXGD002030	Nephrotic Syndrome	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028077	BXGD002069	Nyctalopia	Eye Diseases
C0028738	BXGD002081	Nystagmus	Eye Diseases; Nervous System Diseases
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029089	BXGD002107	Ophthalmoplegia	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029124	BXGD002113	Optic Atrophy	Eye Diseases; Nervous System Diseases
C0029132	BXGD002117	Disorder of the optic nerve	Eye Diseases; Nervous System Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0029463	BXGD002160	Osteosarcoma	Neoplasms
C0030305	BXGD002206	Pancreatitis	Digestive System Diseases
C0030554	BXGD002239	Paresthesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0032915	BXGD002380	Preexcitation Syndrome	Cardiovascular Diseases
C0033377	BXGD002406	Ptosis	Pathological Conditions, Signs and Symptoms
C0033687	BXGD002415	Proteinuria	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0034012	BXGD002449	Delayed Puberty	Endocrine System Diseases
C0034065	BXGD002454	Pulmonary Embolism	Respiratory Tract Diseases; Cardiovascular Diseases
C0035229	BXGD002516	Respiratory Insufficiency	Respiratory Tract Diseases
C0035334	BXGD002539	Retinitis Pigmentosa	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0037769	BXGD002701	West Syndrome	Nervous System Diseases
C0038379	BXGD002752	Strabismus	Eye Diseases; Nervous System Diseases
C0038433	BXGD002754	Streptozotocin Diabetes	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0038644	BXGD002776	Sudden infant death syndrome	Pathological Conditions, Signs and Symptoms
C0040147	BXGD002847	Thyroiditis	Endocrine System Diseases
C0040250	BXGD002853	Tinea Capitis	Infections; Skin and Connective Tissue Diseases
C0040822	BXGD002885	Tremor	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042963	BXGD003018	Vomiting	Pathological Conditions, Signs and Symptoms
C0043202	BXGD003037	Wolff-Parkinson-White Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0085207	BXGD003140	Gestational Diabetes	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085298	BXGD003155	Sudden Cardiac Death	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085584	BXGD003195	Encephalopathies	Nervous System Diseases
C0085605	BXGD003200	Liver Failure	Digestive System Diseases
C0086543	BXGD003294	Cataract	Eye Diseases
C0149721	BXGD003349	Left Ventricular Hypertrophy	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149793	BXGD003366	Amaurosis Fugax	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0149931	BXGD003388	Migraine Disorders	Nervous System Diseases
C0151313	BXGD003413	Sensory neuropathy	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151611	BXGD003447	Electroencephalogram abnormal	Nervous System Diseases
C0151786	BXGD003475	Muscle Weakness	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151888	BXGD003497	Hyporeflexia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151889	BXGD003498	Hyperreflexia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152020	BXGD003519	Gastroparesis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0152025	BXGD003521	Polyneuropathy	Nervous System Diseases
C0152191	BXGD003556	Scotoma, Central	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0154835	BXGD003748	Retinal telangiectasia	Cardiovascular Diseases
C0155305	BXGD003785	Optic Neuropathy, Ischemic	Eye Diseases; Nervous System Diseases; Cardiovascular Diseases
C0162670	BXGD003970	Mitochondrial Myopathies	Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0162671	BXGD003971	MELAS Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C0205642	BXGD004094	Adenocarcinoma, Oxyphilic	Neoplasms
C0231528	BXGD004496	Myalgia	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0232466	BXGD004543	Feeding difficulties
C0233794	BXGD004618	Memory impairment	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234378	BXGD004661	Static Tremor	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234428	BXGD004666	Disturbance of consciousness
C0238111	BXGD004877	Lennox-Gastaut syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0241005	BXGD005072	Creatine phosphokinase serum increased
C0242698	BXGD005189	Ventricular Dysfunction, Left	Cardiovascular Diseases
C0262361	BXGD005229	Growth abnormality
C0268630	BXGD006016	Hyper-beta-alaninemia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0268731	BXGD006029	Renal glomerular disease	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0270612	BXGD006081	Leukoencephalopathy	Nervous System Diseases
C0270685	BXGD006084	Cerebral calcification	Nutritional and Metabolic Diseases; Nervous System Diseases
C0270922	BXGD006134	Peripheral demyelinating neuropathy	Immune System Diseases; Nervous System Diseases
C0271196	BXGD006171	Scotoma, Centrocecal	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0338451	BXGD007176	Frontotemporal dementia	Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0338614	BXGD007208	Psychotic episodes	Mental Disorders
C0340643	BXGD007357	Dissection of aorta	Cardiovascular Diseases
C0342776	BXGD007546	Nicotinamide adenine dinucleotide coenzyme Q reductase deficiency
C0344232	BXGD007659	Blurred vision	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0349588	BXGD007933	Short stature
C0376480	BXGD007998	Gingival Overgrowth	Stomatognathic Diseases
C0393593	BXGD008103	Dystonia Disorders	Nervous System Diseases
C0410000	BXGD008406	Overlap syndrome	Skin and Connective Tissue Diseases; Immune System Diseases
C0424448	BXGD008529	Mask-like facies	Nervous System Diseases
C0452138	BXGD008831	Sensorineural hearing loss, bilateral	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0456909	BXGD008883	Blindness	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397	BXGD008991	Electroretinogram abnormal
C0476403	BXGD008992	Electromyogram abnormal
C0494475	BXGD009030	Tonic - clonic seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0497327	BXGD009061	Dementia	Nervous System Diseases; Mental Disorders
C0522214	BXGD009196	Abnormal visual evoked potential	Nervous System Diseases
C0541764	BXGD009259	Delayed bone age
C0541794	BXGD009262	Skeletal muscle atrophy
C0542476	BXGD009276	Forgetful	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0543888	BXGD009300	Epileptic encephalopathy	Nervous System Diseases
C0549473	BXGD009384	Thyroid carcinoma	Neoplasms; Endocrine System Diseases
C0554970	BXGD009428	Pallor of optic disc
C0557874	BXGD009444	Global developmental delay
C0559106	BXGD009465	Ventricular preexcitation	Pathological Conditions, Signs and Symptoms
C0585442	BXGD009593	Osteosarcoma of bone	Neoplasms
C0745730	BXGD010132	Multiple lipomata	Neoplasms
C0751401	BXGD010427	Ophthalmoparesis	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0751651	BXGD010539	Mitochondrial Diseases	Nutritional and Metabolic Diseases
C0751837	BXGD010604	Gait Ataxia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0878544	BXGD011368	Cardiomyopathies	Cardiovascular Diseases
C0917796	BXGD011408	Optic Atrophy, Hereditary, Leber	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0917798	BXGD011409	Cerebral Ischemia	Nervous System Diseases; Cardiovascular Diseases
C1112256	BXGD011655	Sensorimotor neuropathy
C1167918	BXGD011779	Increased CSF lactate
C1263846	BXGD011897	Attention deficit hyperactivity disorder	Mental Disorders
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1332986	BXGD012574	Childhood Osteosarcoma	Neoplasms
C1445953	BXGD013080	Poor eye contact	Mental Disorders
C1531647	BXGD013301	Cerebral ventriculomegaly	Nervous System Diseases
C1557375	BXGD013360	Blurred Vision, CTCAE
C1565489	BXGD013401	Renal Insufficiency	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1697453	BXGD013507	Spontaneous hematomas
C1836038	BXGD014073	Poor head control	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836440	BXGD014115	Increased serum lactate	Nutritional and Metabolic Diseases
C1836735	BXGD014155	hypopigmented skin patch	Skin and Connective Tissue Diseases
C1836830	BXGD014165	Developmental regression	Mental Disorders
C1837249	BXGD014210	Malformations of Cortical Development, Group II	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1837397	BXGD014227	Severe global developmental delay
C1838979	BXGD014349	MITOCHONDRIAL COMPLEX I DEFICIENCY	Nutritional and Metabolic Diseases
C1838990	BXGD014350	ALZHEIMER DISEASE, SUSCEPTIBILITY TO, MITOCHONDRIAL
C1838993	BXGD014351	Episodic vomiting	Pathological Conditions, Signs and Symptoms
C1839040	BXGD014354	LEBER OPTIC ATROPHY AND DYSTONIA	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C1839532	BXGD014382	Low plasma citrulline
C1839603	BXGD014388	Proximal tubulopathy	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1842820	BXGD014538	Cardiac conduction abnormality
C1843077	BXGD014553	Segmental peripheral demyelination/remyelination
C1843156	BXGD014561	Progressive sensorineural hearing impairment	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1844945	BXGD014698	Episodic respiratory distress
C1847515	BXGD014869	Paroxysmal involuntary eye movements
C1849211	BXGD015023	Generalized hirsutism	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1849488	BXGD015058	Increased serum pyruvate
C1853141	BXGD015307	Slow decrease in visual acuity
C1855285	BXGD015483	Protruding ear
C1856507	BXGD015614	Bulbar signs
C1857287	BXGD015692	Stroke-like episode	Nervous System Diseases; Cardiovascular Diseases
C1857640	BXGD015726	Decreased nerve conduction velocity
C1860475	BXGD015985	Retinal vascular tortuosity
C1860834	BXGD016006	Infantile muscular hypotonia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1861403	BXGD016045	Variable expressivity
C1862475	BXGD016132	Abnormality of retinal pigmentation
C1866934	BXGD016427	Reduced tendon reflexes	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1963165	BXGD016685	Malabsorption, CTCAE
C1963167	BXGD016686	Memory Impairment, CTCAE 3.0
C1963184	BXGD016688	Nystagmus, CTCAE 3.0
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2674608	BXGD017250	Feeding difficulties in infancy
C2677650	BXGD017382	Decreased activity of mitochondrial complex I
C2751582	BXGD017726	Mitochondrial respiratory chain defects
C2919142	BXGD017867	Short Stature, CTCAE
C2931092	BXGD017955	Maternally Inherited Leigh Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2973725	BXGD018205	Pulmonary arterial hypertension	Respiratory Tract Diseases; Cardiovascular Diseases
C3203102	BXGD018555	Idiopathic pulmonary arterial hypertension	Respiratory Tract Diseases
C3275417	BXGD018663	Ragged-red muscle fibers
C3278923	BXGD018748	Dilated ventricles (finding)
C3279222	BXGD018751	Aplasia/Hypoplasia of the cerebellum
C3502298	BXGD019043	Lactic Acidosis, Fatal Infantile	Nutritional and Metabolic Diseases
C3665346	BXGD019278	Unspecified visual loss	Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347	BXGD019279	Visual Impairment	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386	BXGD019284	Abnormal vision	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714745	BXGD019427	Malabsorption	Digestive System Diseases
C3714756	BXGD019429	Intellectual Disability	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3810365	BXGD019652	Central visual impairment	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3887709	BXGD019918	Optic Neuropathy	Eye Diseases; Nervous System Diseases
C3887898	BXGD019926	Infantile Spasm	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021546	BXGD020663	Abnormal mitochondria in muscle tissue
C4021569	BXGD020677	Central retinal vessel vascular tortuosity
C4021734	BXGD020742	Abnormality of mitochondrial metabolism
C4021759	BXGD020762	Generalized myoclonic seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021795	BXGD020785	Abnormality of Krebs cycle metabolism
C4022012	BXGD020868	Death in early adulthood
C4022013	BXGD020869	Multiple glomerular cysts
C4022748	BXGD020979	Focal T2 hyperintense brainstem lesion
C4024926	BXGD021478	Focal T2 hyperintense basal ganglia lesion
C4025585	BXGD021678	Lacticaciduria	Nutritional and Metabolic Diseases
C4025732	BXGD021764	Tubulointerstitial abnormality
C4025821	BXGD021809	Anterior hypopituitarism	Nervous System Diseases; Endocrine System Diseases
C4048268	BXGD021896	Cortical visual impairment	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4520679	BXGD023033	Abnormal macular morphology	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4521256	BXGD023058	Glomerulopathy Assessment
C4531122	BXGD023190	Abnormal speech prosody
C4551472	BXGD023303	Hypertrophic obstructive cardiomyopathy	Cardiovascular Diseases
C4551583	BXGD023361	Cerebral cortical atrophy
C4551714	BXGD023398	Rod-Cone Dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4553743	BXGD023548	Spasticity, CTCAE
C4553765	BXGD023551	Memory Impairment, CTCAE 5.0
C4554036	BXGD023557	Nystagmus, CTCAE 5.0
C4721453	BXGD023744	Peripheral Nervous System Diseases	Nervous System Diseases
C4722144	BXGD023790	MITOCHONDRIAL COMPLEX I DEFICIENCY, MITOCHONDRIAL TYPE 3 (finding)

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0002953	2-Phenethyl isothiocyanate		163.24
BXGC0005989	Auraptene		298.38
BXGC0014139	R-(+)-Marmin		332.16
BXGC0015383	7-(6'r-Hydroxy-3',7'-Dimethyl-2'e,7'-Octadienyloxy)Coumarin		314.15
BXGC0031377	7-[(E,6R)-7-Chloro-6-Hydroxy-3,7-Dimethyloct-2-Enoxy]Chromen-2-One		350.13
BXGC0032047	7-[(2E)-3,7-Dimethylocta-2,6-Dienoxy]-6-Methoxychromen-2-One		328.17
BXGC0035162	Dehydromarmeline		335.19
BXGC0037648	(+)-9'-Isovaleroxylariciresinol		444.21
BXGC0039815	7-[(E,6R)-6-Hydroxy-7-Methoxy-3,7-Dimethyloct-2-Enoxy]Chromen-2-One		346.18
BXGC0045118	R-(+)-Marmin-6'-Octanoate		458.27
BXGC0045119	R-(+)-Marmin-6'-Undecanoate		500.31
BXGC0045120	R-(+)-Marmin-6'-palmitate		570.39
BXGC0045121	R-(+)-Marmin-6'-Linoleate		594.39
BXGC0045122	R-(+)-Marmin-6'-cis-vaccenoate		596.41

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}