Showing entry for Ryanodine receptor 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019367
Protein NameRyanodine receptor 2
Uniport IdQ92736
GeneRYR2
Gene Id6262
DomainIns145_P3_rec; Ion_trans; MIR; RIH_assoc; RR_TM4-6; RYDR_ITPR; RyR; SPRY
Pfam PF08709   PF00520   PF02815   PF08454   PF06459   PF01365   PF02026   PF00622  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0060402 calcium ion transport into cytosol
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0035584 calcium-mediated signaling using intracellular calcium source
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0003300 cardiac muscle hypertrophy
Biological Process GO:0086064 cell communication by electrical coupling involved in cardiac conduction
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0071313 cellular response to caffeine
Biological Process GO:0071872 cellular response to epinephrine stimulus
Biological Process GO:0005513 detection of calcium ion
Biological Process GO:0003143 embryonic heart tube morphogenesis
Biological Process GO:0072599 establishment of protein localization to endoplasmic reticulum
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0003220 left ventricular cardiac muscle tissue morphogenesis
Biological Process GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity
Biological Process GO:0010460 positive regulation of heart rate
Biological Process GO:0051284 positive regulation of sequestering of calcium ion
Biological Process GO:0098735 positive regulation of the force of heart contraction
Biological Process GO:0086029 Purkinje myocyte to ventricular cardiac muscle cell signaling
Biological Process GO:0098910 regulation of atrial cardiac muscle cell action potential
Biological Process GO:0098904 regulation of AV node cell action potential
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0055117 regulation of cardiac muscle contraction
Biological Process GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:0051480 regulation of cytosolic calcium ion concentration
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0098907 regulation of SA node cell action potential
Biological Process GO:0098911 regulation of ventricular cardiac muscle cell action potential
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0031000 response to caffeine
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0014850 response to muscle activity
Biological Process GO:0035994 response to muscle stretch
Biological Process GO:0051775 response to redox state
Biological Process GO:0070296 sarcoplasmic reticulum calcium ion transport
Biological Process GO:0097050 type B pancreatic cell apoptotic process
Biological Process GO:0086005 ventricular cardiac muscle cell action potential
molecular function GO:0005262 calcium channel activity
molecular function GO:0048763 calcium-induced calcium release activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0015278 calcium-release channel activity
molecular function GO:0005516 calmodulin binding
molecular function GO:0019899 enzyme binding
molecular function GO:0042802 identical protein binding
molecular function GO:0044325 ion channel binding
molecular function GO:0034236 protein kinase A catalytic subunit binding
molecular function GO:0034237 protein kinase A regulatory subunit binding
molecular function GO:0043621 protein self-association
molecular function GO:0005219 ryanodine-sensitive calcium-release channel activity
molecular function GO:0043924 suramin binding
cellular component GO:0034704 calcium channel complex
cellular component GO:0030659 cytoplasmic vesicle membrane
cellular component GO:0014701 junctional sarcoplasmic reticulum membrane
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0042383 sarcolemma
cellular component GO:0016529 sarcoplasmic reticulum
cellular component GO:0033017 sarcoplasmic reticulum membrane
cellular component GO:0005790 smooth endoplasmic reticulum
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-2672351 Stimuli-sensing channels
R-HSA-382551 Transport of small molecules
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003466 BXGD000193 Anus, Imperforate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011071 BXGD000696 Sudden death Pathological Conditions, Signs and Symptoms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0016529 BXGD001068 Forced expiratory volume function
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018824 BXGD001237 Heart valve disease Cardiovascular Diseases
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0020450 BXGD001388 Hyperemesis Gravidarum Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020725 BXGD001465 Type II Mucolipidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0021122 BXGD001481 Disruptive, Impulse Control, and Conduct Disorders Mental Disorders
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0024591 BXGD001789 Malignant hyperpyrexia due to anesthesia Pathological Conditions, Signs and Symptoms
C0025202 BXGD001832 melanoma Neoplasms
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0035204 BXGD002511 Respiration Disorders Respiratory Tract Diseases
C0035410 BXGD002546 Rhabdomyolysis Musculoskeletal Diseases
C0036346 BXGD002602 Schizophrenia, Childhood Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038644 BXGD002776 Sudden infant death syndrome Pathological Conditions, Signs and Symptoms
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039231 BXGD002799 Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0039685 BXGD002825 Tetralogy of Fallot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0040100 BXGD002840 Thymoma Neoplasms; Hemic and Lymphatic Diseases
C0040479 BXGD002870 Torsades de Pointes Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0042834 BXGD003004 Vital capacity
C0080203 BXGD003108 Tachyarrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0086209 BXGD003270 Emotional Stress Behavior and Behavior Mechanisms
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151636 BXGD003451 Premature ventricular contractions Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0152164 BXGD003550 Cyclical vomiting syndrome (disorder) Pathological Conditions, Signs and Symptoms
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162534 BXGD003953 Prion Diseases Infections; Nervous System Diseases
C0162770 BXGD003980 Right Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0206042 BXGD004145 Fatal Familial Insomnia Infections; Nervous System Diseases
C0231528 BXGD004496 Myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0232197 BXGD004536 Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235242 BXGD004733 Syncope, Effort Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235480 BXGD004751 Paroxysmal atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0236734 BXGD004823 Caffeine related disorders
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0264716 BXGD005417 Chronic heart failure Cardiovascular Diseases
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0271790 BXGD006259 Subclinical hypothyroidism Endocrine System Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0340278 BXGD007313 Atrial hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0340485 BXGD007334 Familial ventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0340486 BXGD007335 Induced ventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0340493 BXGD007338 Paroxysmal familial ventricular fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0344424 BXGD007669 Ventricular Arrhythmia by ECG Finding
C0344432 BXGD007670 Ventricular tachycardia, polymorphic Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0348617 BXGD007877 Other cardiomyopathies Cardiovascular Diseases
C0349788 BXGD007956 Arrhythmogenic Right Ventricular Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0410000 BXGD008406 Overlap syndrome Skin and Connective Tissue Diseases; Immune System Diseases
C0410158 BXGD008408 Muscle damage
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0557874 BXGD009444 Global developmental delay
C0677898 BXGD009735 invasive cancer Neoplasms
C0694539 BXGD009849 Chronic atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0741923 BXGD010045 cardiac event
C0751534 BXGD010494 Syncopal Episode Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751951 BXGD010648 Central Core Myopathy (disorder) Musculoskeletal Diseases; Nervous System Diseases
C0853897 BXGD010985 Diabetic Cardiomyopathies Endocrine System Diseases; Cardiovascular Diseases
C0855329 BXGD011084 Electrocardiogram change
C0860659 BXGD011240 Aloof
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0940937 BXGD011490 precancerous lesions
C1142166 BXGD011736 Brugada Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1386553 BXGD012952 Caffeine dependence Chemically-Induced Disorders; Mental Disorders
C1397307 BXGD012996 Cardiac fibrosis
C1445957 BXGD013081 Serum total cholesterol measurement
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1560249 BXGD013361 Adverse Event Associated with Cardiac Arrhythmia
C1563715 BXGD013389 Andersen Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1611743 BXGD013456 Familial (FPAH)
C1631597 BXGD013480 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1832931 BXGD013885 ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1852467 BXGD015283 Creutzfeldt-Jakob Disease, Sporadic Infections; Nervous System Diseases; Mental Disorders
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1858430 BXGD015792 Death in infancy
C1883529 BXGD016597 Ventricular Arrhythmia, CTCAE 3.0
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1960469 BXGD016664 Left ventricular noncompaction Cardiovascular Diseases
C2063326 BXGD016902 Right ventricular cardiomyopathy Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2348199 BXGD017054 Short Qt Syndrome Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2677794 BXGD017388 Stress-induced polymorphic ventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2751898 BXGD017749 Ventricular Fibrillation, Paroxysmal Familial, 1 Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2930902 BXGD017914 Bidirectional tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C3150943 BXGD018362 Long Qt Syndrome 2 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C3698186 BXGD019366 Cardiac channelopathy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4021133 BXGD020563 Left ventricular noncompaction cardiomyopathy Pathological Conditions, Signs and Symptoms
C4053736 BXGD021969 Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4476545 BXGD022826 Dilatation of the ventricular cavity Cardiovascular Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4553764 BXGD023550 Ventricular Arrhythmia, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001502 Caffeine 194.19
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein