protein

Showing entry for Growth/differentiation factor 8

General Target Information
BXGT Id	BXGT023280
Protein Name	Growth/differentiation factor 8
Uniport Id	O14793
Gene	MSTN
Gene Id	2660
Domain	TGFb_propeptide; TGF_beta
Pfam	PF00019 PF00688
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
3. Environmental Information Processing	3.3 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0071549	cellular response to dexamethasone stimulus
Biological Process	GO:0046716	muscle cell cellular homeostasis
Biological Process	GO:0007517	muscle organ development
Biological Process	GO:0014839	myoblast migration involved in skeletal muscle regeneration
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway
Biological Process	GO:0033673	negative regulation of kinase activity
Biological Process	GO:0014741	negative regulation of muscle hypertrophy
Biological Process	GO:0045662	negative regulation of myoblast differentiation
Biological Process	GO:2000818	negative regulation of myoblast proliferation
Biological Process	GO:0051898	negative regulation of protein kinase B signaling
Biological Process	GO:1902725	negative regulation of satellite cell differentiation
Biological Process	GO:1902723	negative regulation of skeletal muscle satellite cell proliferation
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth
Biological Process	GO:0022602	ovulation cycle process
Biological Process	GO:0010592	positive regulation of lamellipodium assembly
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
Biological Process	GO:0045893	positive regulation of transcription, DNA-templated
Biological Process	GO:0051602	response to electrical stimulus
Biological Process	GO:0043627	response to estrogen
Biological Process	GO:0045471	response to ethanol
Biological Process	GO:0009629	response to gravity
Biological Process	GO:0009408	response to heat
Biological Process	GO:0014850	response to muscle activity
Biological Process	GO:0033574	response to testosterone
Biological Process	GO:0014732	skeletal muscle atrophy
Biological Process	GO:0060395	SMAD protein signal transduction
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway
molecular function	GO:0005125	cytokine activity
molecular function	GO:0008083	growth factor activity
molecular function	GO:0008201	heparin binding
molecular function	GO:0042802	identical protein binding
molecular function	GO:0042803	protein homodimerization activity
molecular function	GO:0005102	signaling receptor binding
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005615	extracellular space

Reactome

Pathway Id	Pathway Name
R-HSA-212436	Generic Transcription Pathway
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)
R-HSA-9614085	FOXO-mediated transcription
R-HSA-9617828	FOXO-mediated transcription of cell cycle genes

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001175	BXGD000029	Acquired Immunodeficiency Syndrome	Infections; Immune System Diseases
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002736	BXGD000127	Amyotrophic Lateral Sclerosis	Nutritional and Metabolic Diseases; Nervous System Diseases
C0003125	BXGD000179	Anorexia Nervosa	Mental Disorders
C0003507	BXGD000203	Aortic Valve Stenosis	Cardiovascular Diseases
C0003838	BXGD000224	Arterial Occlusive Diseases	Cardiovascular Diseases
C0003850	BXGD000225	Arteriosclerosis	Cardiovascular Diseases
C0003864	BXGD000231	Arthritis	Musculoskeletal Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153	BXGD000260	Atherosclerosis	Cardiovascular Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006625	BXGD000401	Cachexia	Pathological Conditions, Signs and Symptoms
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007103	BXGD000426	Malignant neoplasm of endometrium	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007194	BXGD000452	Hypertrophic Cardiomyopathy	Cardiovascular Diseases
C0007222	BXGD000454	Cardiovascular Diseases	Cardiovascular Diseases
C0007785	BXGD000485	Cerebral Infarction	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0008497	BXGD000549	Choriocarcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009081	BXGD000581	Congenital clubfoot	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009241	BXGD000595	Cognition Disorders	Mental Disorders
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0011570	BXGD000729	Mental Depression	Behavior and Behavior Mechanisms
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013264	BXGD000808	Muscular Dystrophy, Duchenne	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0013390	BXGD000828	Dysmenorrhea	Pathological Conditions, Signs and Symptoms
C0013720	BXGD000861	Ehlers-Danlos Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0014175	BXGD000904	Endometriosis	Female Urogenital Diseases and Pregnancy Complications
C0015695	BXGD001013	Fatty Liver	Digestive System Diseases
C0017921	BXGD001152	Glycogen storage disease type II	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0017924	BXGD001155	Glycogen Storage Disease Type V	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0018081	BXGD001171	Gonorrhea	Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0018801	BXGD001226	Heart failure	Cardiovascular Diseases
C0018802	BXGD001227	Congestive heart failure	Cardiovascular Diseases
C0019829	BXGD001350	Hodgkin Disease	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020179	BXGD001363	Huntington Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020456	BXGD001392	Hyperglycemia	Nutritional and Metabolic Diseases
C0020459	BXGD001394	Hyperinsulinism	Nutritional and Metabolic Diseases
C0020676	BXGD001462	Hypothyroidism	Endocrine System Diseases
C0021167	BXGD001487	Incontinence	Nervous System Diseases
C0021846	BXGD001522	Intestinal Polyps	Pathological Conditions, Signs and Symptoms
C0022735	BXGD001581	Klinefelter Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0023212	BXGD001616	Left-Sided Heart Failure	Cardiovascular Diseases
C0023267	BXGD001626	Fibroid Tumor	Neoplasms
C0023890	BXGD001713	Liver Cirrhosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895	BXGD001717	Liver diseases	Digestive System Diseases
C0024117	BXGD001734	Chronic Obstructive Airway Disease	Respiratory Tract Diseases
C0025517	BXGD001875	Metabolic Diseases	Nutritional and Metabolic Diseases
C0026846	BXGD001939	Muscular Atrophy	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026847	BXGD001940	Spinal Muscular Atrophy	Nervous System Diseases
C0026848	BXGD001941	Myopathy	Musculoskeletal Diseases; Nervous System Diseases
C0026850	BXGD001942	Muscular Dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027051	BXGD001963	Myocardial Infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027121	BXGD001973	Myositis	Musculoskeletal Diseases; Nervous System Diseases
C0027127	BXGD001977	Myotonia Congenita	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027868	BXGD002053	Neuromuscular Diseases	Nervous System Diseases
C0028259	BXGD002073	Nodule
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0029434	BXGD002146	Osteogenesis Imperfecta	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0029453	BXGD002154	Osteopenia	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456	BXGD002157	Osteoporosis	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030552	BXGD002238	Paresis	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0031115	BXGD002284	Peripheral angiopathy in diseases classified elsewhere	Cardiovascular Diseases
C0032460	BXGD002355	Polycystic Ovary Syndrome	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0035412	BXGD002548	Rhabdomyosarcoma	Neoplasms
C0038454	BXGD002760	Cerebrovascular accident	Nervous System Diseases; Cardiovascular Diseases
C0041296	BXGD002903	Tuberculosis	Infections
C0041948	BXGD002939	Uremia	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0041956	BXGD002942	Ureteral obstruction	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042025	BXGD002950	Urinary Stress Incontinence	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042133	BXGD002960	Uterine Fibroids	Neoplasms
C0042769	BXGD002999	Virus Diseases	Infections
C0043046	BXGD003024	Wasting Syndrome	Nutritional and Metabolic Diseases
C0085207	BXGD003140	Gestational Diabetes	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0149925	BXGD003387	Small cell carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0151786	BXGD003475	Muscle Weakness	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0154251	BXGD003710	Lipid Metabolism Disorders	Nutritional and Metabolic Diseases
C0155626	BXGD003806	Acute myocardial infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0156369	BXGD003853	Uterine Polyp	Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0162309	BXGD003934	Adrenoleukodystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0162429	BXGD003942	Malnutrition	Nutritional and Metabolic Diseases
C0162666	BXGD003967	Mitochondrial Encephalomyopathies	Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0206157	BXGD004165	Myopathies, Nemaline	Musculoskeletal Diseases; Nervous System Diseases
C0206650	BXGD004214	Fibroadenoma	Neoplasms
C0220611	BXGD004295	Childhood Rhabdomyosarcoma	Neoplasms
C0220994	BXGD004357	Hyperammonemia	Pathological Conditions, Signs and Symptoms
C0221170	BXGD004400	Muscular stiffness	Nervous System Diseases
C0231230	BXGD004485	Fatigability
C0234233	BXGD004636	Sore to touch	Pathological Conditions, Signs and Symptoms; Mental Disorders
C0234958	BXGD004702	Muscle degeneration	Musculoskeletal Diseases
C0234985	BXGD004708	Mental deterioration	Mental Disorders
C0235527	BXGD004753	Heart Failure, Right-Sided	Cardiovascular Diseases
C0236033	BXGD004806	Muscle hypertrophy	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0238190	BXGD004890	Inclusion Body Myositis (disorder)	Musculoskeletal Diseases; Nervous System Diseases
C0238288	BXGD004905	Muscular Dystrophy, Facioscapulohumeral	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0239946	BXGD005010	Fibrosis, Liver	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242350	BXGD005154	Erectile dysfunction	Male Urogenital Diseases; Mental Disorders
C0242381	BXGD005159	Lyme Arthritis	Infections
C0243038	BXGD005211	Carcinoma, Lewis Lung	Neoplasms
C0264716	BXGD005417	Chronic heart failure	Cardiovascular Diseases
C0269102	BXGD006053	Endometrioma	Female Urogenital Diseases and Pregnancy Complications
C0270952	BXGD006139	Muscular Dystrophy, Oculopharyngeal	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0271623	BXGD006222	Hypogonadotropic hypogonadism	Endocrine System Diseases
C0279550	BXGD006635	Adult Rhabdomyosarcoma	Neoplasms
C0338656	BXGD007211	Impaired cognition	Mental Disorders
C0340044	BXGD007300	Acute exacerbation of chronic obstructive airways disease	Respiratory Tract Diseases
C0340643	BXGD007357	Dissection of aorta	Cardiovascular Diseases
C0341858	BXGD007425	Endometriosis of uterus	Female Urogenital Diseases and Pregnancy Complications
C0342649	BXGD007522	Vascular calcification	Nutritional and Metabolic Diseases
C0342751	BXGD007542	Generalized glycogen storage disease of infants	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0343755	BXGD007643	HIV Wasting Syndrome	Nutritional and Metabolic Diseases; Infections; Immune System Diseases
C0344315	BXGD007666	Depressed mood	Behavior and Behavior Mechanisms
C0362046	BXGD007959	Prediabetes syndrome	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0376154	BXGD007980	Skin callus	Skin and Connective Tissue Diseases
C0398356	BXGD008185	Abdominal aortic atherosclerosis
C0409959	BXGD008400	Osteoarthritis, Knee	Musculoskeletal Diseases
C0476089	BXGD008977	Endometrial Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0521170	BXGD009131	Osteoporotic Fractures	Wounds and Injuries
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0686353	BXGD009833	Muscular Dystrophies, Limb-Girdle	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0730607	BXGD009967	Severe chronic obstructive pulmonary disease	Respiratory Tract Diseases
C0751713	BXGD010564	Inclusion Body Myopathy, Sporadic	Musculoskeletal Diseases; Nervous System Diseases
C0856169	BXGD011096	Endothelial dysfunction
C0856742	BXGD011111	Post MI	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0858252	BXGD011172	Breast adenocarcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0860197	BXGD011218	Advanced chronic liver disease
C0872084	BXGD011319	Sarcopenia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0877009	BXGD011326	Muscle fibrosis
C0917713	BXGD011404	Becker Muscular Dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1153706	BXGD011769	Endometrial adenocarcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1285162	BXGD012167	Degenerative disorder	Pathological Conditions, Signs and Symptoms
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1391732	BXGD012971	Cancer cachexia
C1397307	BXGD012996	Cardiac fibrosis
C1561643	BXGD013363	Chronic Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1565489	BXGD013401	Renal Insufficiency	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1623038	BXGD013475	Cirrhosis	Pathological Conditions, Signs and Symptoms
C1832567	BXGD013853	MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1C	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1959583	BXGD016637	Myocardial Failure	Cardiovascular Diseases
C1961112	BXGD016674	Heart Decompensation	Cardiovascular Diseases
C2063866	BXGD016906	Depressive Disorder, Treatment-Resistant	Mental Disorders
C2265792	BXGD017012	Skeletal muscle hypertrophy
C2711227	BXGD017478	Steatohepatitis	Digestive System Diseases
C2931112	BXGD017959	Myostatin-related muscle hypertrophy	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C2936781	BXGD018135	Generalized Myotonia of Thomsen	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2939419	BXGD018178	Secondary Neoplasm	Pathological Conditions, Signs and Symptoms; Neoplasms
C3250443	BXGD018584	MYOTONIC DYSTROPHY 1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3489532	BXGD018934	Cone-Rod Dystrophy 2	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4268741	BXGD022327	Age-related sarcopenia
C4509670	BXGD022974	Rheumatoid arthritis in remission	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0003705	Chloride		35.45

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}