Showing entry for Low affinity immunoglobulin gamma Fc region receptor II-b


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023298
Protein NameLow affinity immunoglobulin gamma Fc region receptor II-b
Uniport IdP31994
GeneFCGR2B
Gene Id2213
DomainIg_2
Pfam PF13895  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
5. Organismal Systems 5.8 Development hsa04380 Osteoclast differentiation
5. Organismal Systems 5.1 Immune system hsa04662 B cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04666 Fc gamma R-mediated phagocytosis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05152 Tuberculosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05162 Measles
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0071219 cellular response to molecule of bacterial origin
Biological Process GO:0021549 cerebellum development
Biological Process GO:0006952 defense response
Biological Process GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
Biological Process GO:0002316 follicular B cell differentiation
Biological Process GO:0002266 follicular dendritic cell activation
Biological Process GO:0002436 immune complex clearance by monocytes and macrophages
Biological Process GO:0006955 immune response
Biological Process GO:0016064 immunoglobulin mediated immune response
Biological Process GO:0006954 inflammatory response
Biological Process GO:0002313 mature B cell differentiation involved in immune response
Biological Process GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus
Biological Process GO:0001814 negative regulation of antibody-dependent cellular cytotoxicity
Biological Process GO:0050869 negative regulation of B cell activation
Biological Process GO:0030889 negative regulation of B cell proliferation
Biological Process GO:0050859 negative regulation of B cell receptor signaling pathway
Biological Process GO:0050710 negative regulation of cytokine secretion
Biological Process GO:0043318 negative regulation of cytotoxic T cell degranulation
Biological Process GO:0002605 negative regulation of dendritic cell antigen processing and presentation
Biological Process GO:2001199 negative regulation of dendritic cell differentiation
Biological Process GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin
Biological Process GO:0050777 negative regulation of immune response
Biological Process GO:0002638 negative regulation of immunoglobulin production
Biological Process GO:0032693 negative regulation of interleukin-10 production
Biological Process GO:0043031 negative regulation of macrophage activation
Biological Process GO:1902564 negative regulation of neutrophil activation
Biological Process GO:0050765 negative regulation of phagocytosis
Biological Process GO:0001811 negative regulation of type I hypersensitivity
Biological Process GO:0006911 phagocytosis, engulfment
Biological Process GO:0002922 positive regulation of humoral immune response
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:1901216 positive regulation of neuron death
Biological Process GO:0050766 positive regulation of phagocytosis
Biological Process GO:1905898 positive regulation of response to endoplasmic reticulum stress
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0002819 regulation of adaptive immune response
Biological Process GO:0002622 regulation of B cell antigen processing and presentation
Biological Process GO:1902950 regulation of dendritic spine maintenance
Biological Process GO:0090264 regulation of immune complex clearance by monocytes and macrophages
Biological Process GO:0050776 regulation of immune response
Biological Process GO:0045088 regulation of innate immune response
Biological Process GO:0010469 regulation of signaling receptor activity
Biological Process GO:0009617 response to bacterium
Biological Process GO:0007165 signal transduction
Biological Process GO:0016032 viral process
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0019864 IgG binding
molecular function GO:0019772 low-affinity IgG receptor activity
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0004888 transmembrane signaling receptor activity
cellular component GO:0044297 cell body
cellular component GO:0043197 dendritic spine
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002792 BXGD000129 anaphylaxis Immune System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002878 BXGD000137 Anemia, Hemolytic Hemic and Lymphatic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0005612 BXGD000317 Birth Weight Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0007684 BXGD000472 Central Nervous System Infection Infections; Nervous System Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010414 BXGD000669 Infection by Cryptococcus neoformans Infections
C0011119 BXGD000698 Decompression Sickness Wounds and Injuries
C0011311 BXGD000714 Dengue Fever Infections
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014060 BXGD000882 Encephalitis, St. Louis Infections; Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014761 BXGD000947 Erythroblastosis, Fetal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015923 BXGD001023 Fetal Alcohol Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Chemically-Induced Disorders
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019069 BXGD001277 Hemophilia A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019100 BXGD001283 Severe Dengue Infections
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024266 BXGD001754 Lymphocytic Choriomeningitis Infections; Nervous System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024301 BXGD001759 Lymphoma, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024530 BXGD001783 Malaria Infections
C0024535 BXGD001785 Malaria, Falciparum Infections
C0025202 BXGD001832 melanoma Neoplasms
C0025281 BXGD001848 Meniere Disease Otorhinolaryngologic Diseases
C0025303 BXGD001858 Meningococcal Infections Infections
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031046 BXGD002275 Pericarditis Cardiovascular Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0032231 BXGD002339 Pleurisy Infections; Respiratory Tract Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0034050 BXGD002452 Pulmonary Alveolar Proteinosis Respiratory Tract Diseases
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037054 BXGD002663 Sickle Cell Trait Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0039483 BXGD002813 Giant Cell Arteritis Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042384 BXGD002979 Vasculitis Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0043194 BXGD003036 Wiskott-Aldrich Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085253 BXGD003144 Adult-Onset Still Disease Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0085436 BXGD003177 Meningitis, Cryptococcal Infections; Nervous System Diseases
C0085702 BXGD003247 Monocytosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0151436 BXGD003417 Vasculitis, Leukocytoclastic, Cutaneous Immune System Diseases; Cardiovascular Diseases
C0151480 BXGD003426 Anti-nuclear factor positive Skin and Connective Tissue Diseases
C0153014 BXGD003612 Non-arthropod borne lymphocytic choriomeningitis Infections; Nervous System Diseases
C0154251 BXGD003710 Lipid Metabolism Disorders Nutritional and Metabolic Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0221239 BXGD004416 Rapidly progressive glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0238339 BXGD004914 Hereditary pancreatitis Digestive System Diseases
C0241910 BXGD005123 Autoimmune Chronic Hepatitis Digestive System Diseases; Immune System Diseases
C0242380 BXGD005158 Libman-Sacks Disease Skin and Connective Tissue Diseases; Immune System Diseases
C0242488 BXGD005170 Acute Lung Injury Respiratory Tract Diseases
C0242723 BXGD005193 Parasitemia Pathological Conditions, Signs and Symptoms; Infections
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0266929 BXGD005722 Chronic Periodontitis Stomatognathic Diseases
C0277942 BXGD006486 Butterfly rash Skin and Connective Tissue Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280248 BXGD006726 stage, chronic lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0333983 BXGD006975 Hyperplastic Polyp Pathological Conditions, Signs and Symptoms
C0341299 BXGD007399 Collagenous Sprue Digestive System Diseases; Nutritional and Metabolic Diseases
C0349506 BXGD007912 Photosensitivity of skin Skin and Connective Tissue Diseases
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0403529 BXGD008291 Anti-Glomerular Basement Membrane Disease Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Respiratory Tract Diseases; Immune System Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0677607 BXGD009721 Hashimoto Disease Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0685898 BXGD009826 Food anaphylaxis Digestive System Diseases; Immune System Diseases
C0747479 BXGD010170 Periodontal infection
C0852336 BXGD010941 Immune Hemolytic Anemia Hemic and Lymphatic Diseases
C0852949 BXGD010957 Arteriopathic disease Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0857305 BXGD011143 Thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0920163 BXGD011456 Idiopathic thrombocytopenia
C0949690 BXGD011584 Spondylarthritis Musculoskeletal Diseases
C1142553 BXGD011761 Primary HIV infection Infections; Immune System Diseases
C1300128 BXGD012269 Villitis of unknown etiology
C1318973 BXGD012407 Staphylococcus aureus infection Infections
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1334968 BXGD012749 Nodular Lymphocyte Predominant Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1519680 BXGD013244 Tumor Immunity Pathological Conditions, Signs and Symptoms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2363741 BXGD017100 HIV-1 infection
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2747816 BXGD017577 Complicated malaria Infections
C2895206 BXGD017852 Autoimmune disease (systemic) NOS
C2973529 BXGD018204 Leukocytoclastic vasculitis Immune System Diseases; Cardiovascular Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3805040 BXGD019456 Phospholipidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3810365 BXGD019652 Central visual impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3862275 BXGD019845 SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO
C3887638 BXGD019906 Failure to thrive in infant Pathological Conditions, Signs and Symptoms
C4019436 BXGD020467 Antiphospholipid antibody positivity
C4025886 BXGD021846 Severe periodontitis Stomatognathic Diseases
C4048329 BXGD021904 Immunosuppression
C4529962 BXGD023178 Fatty Liver Disease
C4554344 BXGD023564 IgE-mediated food allergy Immune System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein