Showing entry for ATP-dependent RNA helicase DDX3X


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003938
Protein NameATP-dependent RNA helicase DDX3X
Uniport IdO00571
GeneDDX3X
Gene Id1654
DomainDEAD; Helicase_C
Pfam PF00270   PF00271  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04622 RIG-I-like receptor signaling pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05161 Hepatitis B
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030154 cell differentiation
Biological Process GO:0071243 cellular response to arsenic-containing substance
Biological Process GO:0071470 cellular response to osmotic stress
Biological Process GO:0098586 cellular response to virus
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:0007276 gamete generation
Biological Process GO:0045087 innate immune response
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0097193 intrinsic apoptotic signaling pathway
Biological Process GO:0055088 lipid homeostasis
Biological Process GO:0042256 mature ribosome assembly
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Biological Process GO:1901223 negative regulation of NIK/NF-kappaB signaling
Biological Process GO:0031333 negative regulation of protein-containing complex assembly
Biological Process GO:0017148 negative regulation of translation
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production
Biological Process GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0032727 positive regulation of interferon-alpha production
Biological Process GO:0032728 positive regulation of interferon-beta production
Biological Process GO:1901224 positive regulation of NIK/NF-kappaB signaling
Biological Process GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
Biological Process GO:1901985 positive regulation of protein acetylation
Biological Process GO:0031954 positive regulation of protein autophosphorylation
Biological Process GO:1902523 positive regulation of protein K63-linked ubiquitination
Biological Process GO:0071902 positive regulation of protein serine/threonine kinase activity
Biological Process GO:0034157 positive regulation of toll-like receptor 7 signaling pathway
Biological Process GO:0034161 positive regulation of toll-like receptor 8 signaling pathway
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:0045948 positive regulation of translational initiation
Biological Process GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
Biological Process GO:0045070 positive regulation of viral genome replication
Biological Process GO:1903608 protein localization to cytoplasmic stress granule
Biological Process GO:0009615 response to virus
Biological Process GO:0010501 RNA secondary structure unwinding
Biological Process GO:0034063 stress granule assembly
Biological Process GO:0006413 translational initiation
Biological Process GO:0016032 viral process
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0045296 cadherin binding
molecular function GO:0043273 CTPase activity
molecular function GO:0003677 DNA binding
molecular function GO:0003678 DNA helicase activity
molecular function GO:0008190 eukaryotic initiation factor 4E binding
molecular function GO:0043015 gamma-tubulin binding
molecular function GO:0003924 GTPase activity
molecular function GO:0048027 mRNA 5'-UTR binding
molecular function GO:0003729 mRNA binding
molecular function GO:0017111 nucleoside-triphosphatase activity
molecular function GO:0008143 poly(A) binding
molecular function GO:0043539 protein serine/threonine kinase activator activity
molecular function GO:0043024 ribosomal small subunit binding
molecular function GO:0003723 RNA binding
molecular function GO:0003724 RNA helicase activity
molecular function GO:0035613 RNA stem-loop binding
molecular function GO:0033592 RNA strand annealing activity
molecular function GO:0008134 transcription factor binding
molecular function GO:0031369 translation initiation factor binding
cellular component GO:0031252 cell leading edge
cellular component GO:0005813 centrosome
cellular component GO:0005737 cytoplasm
cellular component GO:0010494 cytoplasmic stress granule
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0030027 lamellipodium
cellular component GO:0072559 NLRP3 inflammasome complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0043186 P granule
cellular component GO:0005886 plasma membrane
cellular component GO:0034774 secretory granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003537 BXGD000208 Aphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014057 BXGD000880 Japanese Encephalitis Infections; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014877 BXGD000967 Esotropia Eye Diseases; Nervous System Diseases
C0019104 BXGD001285 Hemorrhagic Fevers, Viral Infections
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0019572 BXGD001338 Hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0025322 BXGD001863 Premature Menopause Female Urogenital Diseases and Pregnancy Complications
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0034935 BXGD002497 Babinski Reflex
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0040997 BXGD002894 Trigeminal Neuralgia Nervous System Diseases; Stomatognathic Diseases
C0042580 BXGD002992 Vesico-Ureteral Reflux Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0043124 BXGD003031 West Nile Fever Infections; Nervous System Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085215 BXGD003141 Ovarian Failure, Premature Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0086237 BXGD003273 Epilepsy, Cryptogenic Nervous System Diseases
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0086743 BXGD003308 Osteoarthrosis Deformans Musculoskeletal Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152421 BXGD003586 Macrotia
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205671 BXGD004104 Infections, Arenavirus Infections
C0206608 BXGD004184 Flavivirus Infections Infections
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220641 BXGD004305 Lip and Oral Cavity Carcinoma Neoplasms; Stomatognathic Diseases
C0221505 BXGD004466 Lesion of brain
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0235659 BXGD004763 Reduced fetal movement Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0235991 BXGD004802 Small for gestational age (disorder) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0236018 BXGD004804 Aura Nervous System Diseases
C0239234 BXGD004974 Low set ears
C0240543 BXGD005042 Bulbous nose
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0266464 BXGD005676 Polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270790 BXGD006105 Quadriparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0276289 BXGD006418 Zika Virus Infection Infections
C0278488 BXGD006515 Carcinoma breast stage IV
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0281784 BXGD006785 Benign Meningioma Neoplasms; Nervous System Diseases
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346957 BXGD007836 Disseminated Malignant Neoplasm Neoplasms
C0348426 BXGD007871 Benign neoplasm of meninges Neoplasms; Nervous System Diseases
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0398738 BXGD008222 Leukocyte adhesion deficiency type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C0401149 BXGD008273 Chronic constipation Pathological Conditions, Signs and Symptoms
C0423110 BXGD008471 Downward slant of palpebral fissure
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0431380 BXGD008680 Cortical Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0542519 BXGD009279 Congenital absence of kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0557874 BXGD009444 Global developmental delay
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0694549 BXGD009851 Community acquired pneumonia Infections; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0730328 BXGD009959 Central Serous Chorioretinopathy Eye Diseases
C0751111 BXGD010319 Awakening Epilepsy Nervous System Diseases
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0796184 BXGD010810 Corpus Callosum, Agenesis of, with Facial Anomalies and Robin Sequence Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Nervous System Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0856863 BXGD011122 Broad-based gait
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C0871976 BXGD011318 facial features
C1096184 BXGD011607 West Nile viral infection Infections; Nervous System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1260926 BXGD011844 Abnormal pigmentation
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1266086 BXGD011952 Polymorphous low grade adenocarcinoma
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1835884 BXGD014061 Triangular face
C1836806 BXGD014162 Mild microcephaly
C1837404 BXGD014229 High, narrow palate
C1837463 BXGD014235 Narrow face
C1840077 BXGD014434 Anteverted nostril
C1840379 BXGD014459 Cerebellar vermis hypoplasia
C1843367 BXGD014576 Poor school performance
C1845977 BXGD014769 X- linked recessive
C1847879 BXGD014895 X-linked dominant inheritance
C1849265 BXGD015028 Overgrowth
C1855179 BXGD015468 CATARACT, ANTERIOR POLAR Eye Diseases
C1857482 BXGD015706 Slender finger
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1865014 BXGD016282 Long philtrum
C1868571 BXGD016508 Highly arched eyebrow
C1955906 BXGD016613 Lymphoma, Extranodal NK-T-Cell Neoplasms
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3278923 BXGD018748 Dilated ventricles (finding)
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021076 BXGD020542 Iron accumulation in brain
C4021813 BXGD020799 Oral cleft
C4024896 BXGD021461 Motor neuron atrophy
C4085582 BXGD022118 MENTAL RETARDATION, X-LINKED 102
C4289792 BXGD022497 Chronic Active EBV Infection of T-and NK-Cell Type, Systemic Form Infections
C4293686 BXGD022512 Periventricular white matter hyperdensities
C4551488 BXGD023314 Bifid uvula
C4551563 BXGD023351 Microcephaly (physical finding)
C4553743 BXGD023548 Spasticity, CTCAE
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0004275 Acetaldehyde 44.05
BXGC0014051 Allolaurinterol 294.06
BXGC0024261 Adenosine Phosphate 347.06
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein