Showing entry for Polycomb protein EED


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005135
Protein NamePolycomb protein EED
Uniport IdO75530
GeneEED
Gene Id8726
DomainWD40
Pfam PF00400  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1990830 cellular response to leukemia inhibitory factor
Biological Process GO:0006342 chromatin silencing
Biological Process GO:0070734 histone H3-K27 methylation
Biological Process GO:0070317 negative regulation of G0 to G1 transition
Biological Process GO:0045814 negative regulation of gene expression, epigenetic
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0061087 positive regulation of histone H3-K27 methylation
Biological Process GO:2000011 regulation of adaxial/abaxial pattern formation
Biological Process GO:0006349 regulation of gene expression by genetic imprinting
Biological Process GO:0021510 spinal cord development
Biological Process GO:0016032 viral process
molecular function GO:0003682 chromatin binding
molecular function GO:0042054 histone methyltransferase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0001226 RNA polymerase II transcription corepressor binding
cellular component GO:0005829 cytosol
cellular component GO:0035098 ESC/E(Z) complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0045120 pronucleus
cellular component GO:0001739 sex chromatin
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266738 Developmental Biology
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-212436 Generic Transcription Pathway
R-HSA-2262752 Cellular responses to stress
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559583 Cellular Senescence
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-5663205 Infectious disease
R-HSA-6807070 PTEN Regulation
R-HSA-6807070 PTEN Regulation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8953750 Transcriptional Regulation by E2F6
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9609646 HCMV Infection
R-HSA-9609690 HCMV Early Events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0019825 BXGD001349 Hoarseness Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020490 BXGD001403 Hyperopia Eye Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027809 BXGD002040 Neurilemmoma Neoplasms
C0027830 BXGD002046 neurofibroma Neoplasms; Nervous System Diseases
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0027962 BXGD002064 Melanocytic nevus Neoplasms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0032914 BXGD002379 Pre-Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152421 BXGD003586 Macrotia
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0162678 BXGD003974 Neurofibromatoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205824 BXGD004128 Liposarcoma, Dedifferentiated Neoplasms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0206727 BXGD004272 Nerve Sheath Tumors Neoplasms; Nervous System Diseases
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220765 BXGD004340 Weaver-Like Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0221352 BXGD004444 Syndactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0221369 BXGD004453 Acquired Camptodactyly
C0239137 BXGD004965 Coxa valga Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0239234 BXGD004974 Low set ears
C0239479 BXGD004982 Round face
C0241240 BXGD005089 Tall stature
C0263523 BXGD005320 Micronychia (disorder) Skin and Connective Tissue Diseases
C0265210 BXGD005463 Weaver syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0278985 BXGD006619 Adult Extraskeletal Osteosarcoma
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0409348 BXGD008384 Flexion contracture of proximal interphalangeal joint
C0423110 BXGD008471 Downward slant of palpebral fissure
C0423823 BXGD008515 Thin nails Pathological Conditions, Signs and Symptoms
C0423867 BXGD008517 Fine hair
C0426870 BXGD008592 Large hand
C0426891 BXGD008595 Broad thumbs
C0431369 BXGD008674 Dysgenesis of corpus callosum
C0431447 BXGD008690 Synophrys Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0545053 BXGD009323 Advanced bone age
C0549629 BXGD009393 Abnormal delivery
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0557874 BXGD009444 Global developmental delay
C0563243 BXGD009479 Poor coordination Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0576225 BXGD009526 Long foot Musculoskeletal Diseases
C0581342 BXGD009560 Redundant skin Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0685409 BXGD009810 Congenital Camptodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0751374 BXGD010418 Schwannomatosis, Plexiform Neoplasms
C0751689 BXGD010552 Peripheral Nerve Sheath Neoplasm Neoplasms; Nervous System Diseases
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0751691 BXGD010554 Perineurioma Neoplasms; Nervous System Diseases
C0855052 BXGD011062 Extraskeletal Osteosarcoma Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306503 BXGD012363 Congenital exomphalos Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1836542 BXGD014129 Depressed nasal bridge
C1837279 BXGD014217 Hypoplastic toenails
C1838705 BXGD014341 Anteriorly placed anus
C1839797 BXGD014409 Deep philtrum
C1840069 BXGD014433 Sandal gap
C1844813 BXGD014679 Widely spaced teeth
C1848657 BXGD014959 Long ear
C1849089 BXGD015004 Broad forehead
C1849265 BXGD015028 Overgrowth
C1849367 BXGD015046 Nasal bridge wide
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1858091 BXGD015771 Long fingers
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859236 BXGD015867 Prolonged neonatal jaundice Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1865014 BXGD016282 Long philtrum
C1865027 BXGD016287 Hypoplastic iliac wing
C1866241 BXGD016389 Broad foot Musculoskeletal Diseases
C2674608 BXGD017250 Feeding difficulties in infancy
C2986658 BXGD018234 Diffuse Intrinsic Pontine Glioma
C2986703 BXGD018240 Overgrowth Syndrome Pathological Conditions, Signs and Symptoms
C3277753 BXGD018722 Deep-set nails
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3494422 BXGD018966 Retrognathia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C3553764 BXGD019187 Joint hyperflexibility
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4012968 BXGD020124 Mild global developmental delay
C4023915 BXGD021274 Abnormally low-pitched voice
C4025814 BXGD021806 Abnormality of the metaphysis
C4049796 BXGD021951 Abnormality of cardiovascular system morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4072903 BXGD022020 Primary Caesarian section
C4479654 BXGD022946 COHEN-GIBSON SYNDROME
C4551838 BXGD023417 Talipes transversoplanus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4553743 BXGD023548 Spasticity, CTCAE
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0006368 Formic acid 46.03
BXGC0012404 Tanshindiol C 312.1
BXGC0018374 Methyl Tanshinonate 338.12
BXGC0018607 Tanshinone Iib 310.12
BXGC0037599 Tanshinone Iia 294.13
BXGC0040070 Tanshindiol B 312.1
BXGC0052948 Tanshinone I 276.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein