Showing entry for ATP-sensitive inward rectifier potassium channel 10


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011845
Protein NameATP-sensitive inward rectifier potassium channel 10
Uniport IdP78508
GeneKCNJ10
Gene Id3766
DomainIRK; IRK_C
Pfam PF01007   PF17655  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007628 adult walking behavior
Biological Process GO:0022010 central nervous system myelination
Biological Process GO:0051935 glutamate reuptake
Biological Process GO:0055075 potassium ion homeostasis
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:0006813 potassium ion transport
Biological Process GO:0034765 regulation of ion transmembrane transport
Biological Process GO:0048169 regulation of long-term neuronal synaptic plasticity
Biological Process GO:0060075 regulation of resting membrane potential
Biological Process GO:0007601 visual perception
molecular function GO:0015272 ATP-activated inward rectifier potassium channel activity
molecular function GO:0005524 ATP binding
molecular function GO:0005242 inward rectifier potassium channel activity
cellular component GO:0097449 astrocyte projection
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0044297 cell body
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0098793 presynapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-1296059 G protein gated Potassium channels
R-HSA-1296065 Inwardly rectifying K+ channels
R-HSA-1296067 Potassium transport channels
R-HSA-1296071 Potassium Channels
R-HSA-977443 GABA receptor activation
R-HSA-977444 GABA B receptor activation
R-HSA-991365 Activation of GABAB receptors
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004775 BXGD000290 Bartter Disease Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0014394 BXGD000914 Enuresis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0014549 BXGD000929 Tonic-Clonic Epilepsy Nervous System Diseases
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0018021 BXGD001162 Goiter Endocrine System Diseases
C0018776 BXGD001216 Hearing Loss, Central Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018780 BXGD001218 Hearing Loss, High-Frequency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020428 BXGD001377 Hyperaldosteronism Endocrine System Diseases
C0020502 BXGD001410 Hyperparathyroidism Endocrine System Diseases
C0020599 BXGD001441 Hypocalciuria Nutritional and Metabolic Diseases
C0020621 BXGD001449 Hypokalemia Nutritional and Metabolic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0023882 BXGD001710 Little's Disease Nervous System Diseases
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0032617 BXGD002367 Polyuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0035328 BXGD002537 Retinal Vein Occlusion Eye Diseases; Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0038644 BXGD002776 Sudden infant death syndrome Pathological Conditions, Signs and Symptoms
C0040583 BXGD002878 Tracheal Stenosis Respiratory Tract Diseases
C0042164 BXGD002965 Uveitis Eye Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0085570 BXGD003186 Hypokalemic alkalosis Nutritional and Metabolic Diseases
C0085602 BXGD003199 Polydipsia Pathological Conditions, Signs and Symptoms
C0151723 BXGD003466 Hypomagnesemia Nutritional and Metabolic Diseases
C0151747 BXGD003471 Renal tubular disorder Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0220983 BXGD004350 Metabolic alkalosis Nutritional and Metabolic Diseases
C0234376 BXGD004659 Action Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234979 BXGD004707 Dysdiadochokinesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0240783 BXGD005054 Increased circulating renin level
C0240928 BXGD005064 Salt craving Mental Disorders
C0266589 BXGD005698 Congenital ear anomaly NOS (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Otorhinolaryngologic Diseases
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0270857 BXGD006122 Epilepsy, Reflex Nervous System Diseases
C0271829 BXGD006267 Pendred's syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Endocrine System Diseases; Otorhinolaryngologic Diseases
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0342162 BXGD007438 Compensated hypothyroidism Endocrine System Diseases
C0393519 BXGD008078 Cerebellar Ataxia, Early Onset Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0452138 BXGD008831 Sensorineural hearing loss, bilateral Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0557874 BXGD009444 Global developmental delay
C0740279 BXGD009973 Cerebellar atrophy
C0740898 BXGD010014 Hypokalemic metabolic alkalosis
C0751324 BXGD010388 Multiple Sclerosis, Acute Fulminating Immune System Diseases; Nervous System Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1843865 BXGD014615 Vestibular dysfunction
C1846347 BXGD014802 Renal salt wasting
C1846348 BXGD014803 Renal potassium wasting
C1853205 BXGD015316 Glycosylphosphatidylinositol deficiency Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1853666 BXGD015350 Anemia, Diamond-Blackfan, 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1862050 BXGD016098 Cochlear malformation
C1863752 BXGD016196 Enlarged Vestibular Aqueduct Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1865866 BXGD016345 Congenital sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C2607947 BXGD017150 Unilateral deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C2676974 BXGD017351 Hypoplasia of the cochlea
C2748572 BXGD017600 SeSAME syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Otorhinolaryngologic Diseases; Behavior and Behavior Mechanisms
C2748576 BXGD017601 Renal sodium wasting
C3538946 BXGD019082 DEAFNESS, AUTOSOMAL RECESSIVE 4, WITH ENLARGED VESTIBULAR AQUEDUCT Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C3711374 BXGD019382 Nonsyndromic Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4023042 BXGD021081 Abnormality of the mitochondrion
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4551563 BXGD023351 Microcephaly (physical finding)
C4552839 BXGD023527 Hypomagnesemia, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0046755 Yohimbine 354.19
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein