Showing entry for Protein cereblon


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019743
Protein NameProtein cereblon
Uniport IdQ96SW2
GeneCRBN
Gene Id51185
DomainLON_substr_bdg; Yippee-Mis18
Pfam PF02190   PF03226  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034766 negative regulation of ion transmembrane transport
Biological Process GO:0031333 negative regulation of protein-containing complex assembly
Biological Process GO:0031334 positive regulation of protein-containing complex assembly
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0016567 protein ubiquitination
molecular function GO:0044325 ion channel binding
molecular function GO:0046872 metal ion binding
cellular component GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
cellular component GO:0005737 cytoplasm
cellular component GO:0016020 membrane
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-5663205 Infectious disease
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000771 BXGD000008 Abnormalities, Drug-Induced Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020433 BXGD001379 Hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038271 BXGD002742 Stereotyped Behavior Behavior and Behavior Mechanisms
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0152025 BXGD003521 Polyneuropathy Nervous System Diseases
C0200641 BXGD004044 Blood basophil count (lab test)
C0220810 BXGD004346 Congenital defects
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242647 BXGD005184 Mucosa-Associated Lymphoid Tissue Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0262630 BXGD005262 Reduced concentration span Behavior and Behavior Mechanisms
C0265541 BXGD005545 Cranioschisis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266464 BXGD005676 Polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0334634 BXGD007144 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0349532 BXGD007917 Gastric lymphoma Digestive System Diseases; Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0431371 BXGD008676 Absence of septum pellucidum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0431380 BXGD008680 Cortical Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0432365 BXGD008784 Thalidomide embryopathy syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0497552 BXGD009067 Congenital neurologic anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0740404 BXGD009991 Limb defects
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1292753 BXGD012226 Primary Effusion Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1527366 BXGD013280 Salaam Seizures Nervous System Diseases
C1838023 BXGD014289 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 3 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1843942 BXGD014621 Mental Retardation, Autosomal Recessive 2 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1848207 BXGD014916 Poor speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1850900 BXGD015186 Familial primary gastric lymphoma Digestive System Diseases; Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1854301 BXGD015391 Motor delay Mental Disorders
C1855304 BXGD015484 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859470 BXGD015896 Large basal ganglia
C1955690 BXGD016605 Extranodal marginal zone B-cell lymphoma
C1970179 BXGD016812 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 4 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1970193 BXGD016814 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 11 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1970194 BXGD016815 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 10 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1970195 BXGD016816 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 9 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1970197 BXGD016817 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 7 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1970198 BXGD016818 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 6 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1970199 BXGD016819 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 5 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1970200 BXGD016820 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 12 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347761 BXGD017049 Childhood Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C3151462 BXGD018431 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 14
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3280154 BXGD018809 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 16
C3280265 BXGD018815 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 18
C3280523 BXGD018833 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 31
C3280525 BXGD018834 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 29
C3280538 BXGD018836 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 27
C3280539 BXGD018837 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 33
C3280540 BXGD018838 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 30
C3280541 BXGD018839 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 19
C3280542 BXGD018840 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 23
C3280543 BXGD018841 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 24
C3280544 BXGD018842 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 25
C3280545 BXGD018843 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 28
C3281044 BXGD018878 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 34, WITH VARIANT LISSENCEPHALY
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3809672 BXGD019604 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 37
C3809753 BXGD019609 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 38
C3809853 BXGD019615 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 39
C3810080 BXGD019636 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 40
C3810225 BXGD019644 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 41
C3810365 BXGD019652 Central visual impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3900098 BXGD020106 Adult Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C4014343 BXGD020141 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 42
C4014386 BXGD020143 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 43
C4014745 BXGD020165 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 44
C4015172 BXGD020190 SIDEROBLASTIC ANEMIA WITH B-CELL IMMUNODEFICIENCY, PERIODIC FEVERS, AND DEVELOPMENTAL DELAY
C4021219 BXGD020582 Multifocal epileptiform discharges
C4048268 BXGD021896 Cortical visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4310776 BXGD022660 RETINITIS PIGMENTOSA AND ERYTHROCYTIC MICROCYTOSIS
C4551538 BXGD023340 refractory multiple myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C4553743 BXGD023548 Spasticity, CTCAE
C4706503 BXGD023697 Distal monosomy 3p syndrome
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003761 Dimethyl sulfone 94.13
BXGC0042701 Succinimide 99.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein