Showing entry for P2X purinoceptor 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021656
Protein NameP2X purinoceptor 2
Uniport IdQ9UBL9
GeneP2RX2
Gene Id22953
DomainP2X_receptor
Pfam -  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.7 Sensory system hsa04742 Taste transduction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0048266 behavioral response to pain
Biological Process GO:0007596 blood coagulation
Biological Process GO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
Biological Process GO:0007528 neuromuscular junction development
Biological Process GO:0007274 neuromuscular synaptic transmission
Biological Process GO:0030432 peristalsis
Biological Process GO:0010524 positive regulation of calcium ion transport into cytosol
Biological Process GO:0050850 positive regulation of calcium-mediated signaling
Biological Process GO:0033198 response to ATP
Biological Process GO:0009743 response to carbohydrate
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0002931 response to ischemia
Biological Process GO:0007605 sensory perception of sound
Biological Process GO:0050909 sensory perception of taste
Biological Process GO:0048741 skeletal muscle fiber development
Biological Process GO:0014832 urinary bladder smooth muscle contraction
molecular function GO:0005524 ATP binding
molecular function GO:0004931 extracellularly ATP-gated cation channel activity
molecular function GO:0042802 identical protein binding
molecular function GO:0015276 ligand-gated ion channel activity
molecular function GO:0001614 purinergic nucleotide receptor activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005639 integral component of nuclear inner membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0005886 plasma membrane
cellular component GO:0098794 postsynapse
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-418346 Platelet homeostasis
R-HSA-418360 Platelet calcium homeostasis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006012 BXGD000360 Borderline Personality Disorder Mental Disorders
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0008149 BXGD000520 Chlamydia Infections Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011311 BXGD000714 Dengue Fever Infections
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0018780 BXGD001218 Hearing Loss, High-Frequency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040264 BXGD002857 Tinnitus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0085315 BXGD003158 Toxoplasmosis, Cerebral Infections; Nervous System Diseases
C0085548 BXGD003183 Autosomal Recessive Polycystic Kidney Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0086237 BXGD003273 Epilepsy, Cryptogenic Nervous System Diseases
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0162671 BXGD003971 MELAS Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0236018 BXGD004804 Aura Nervous System Diseases
C0241919 BXGD005125 heroin withdrawal
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0458247 BXGD008904 Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0574785 BXGD009506 Lower Urinary Tract Symptoms Pathological Conditions, Signs and Symptoms
C0595921 BXGD009626 Intraocular pressure disorder Eye Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740394 BXGD009989 Hyperuricemia Pathological Conditions, Signs and Symptoms
C0751111 BXGD010319 Awakening Epilepsy Nervous System Diseases
C0751211 BXGD010350 Hyperalgesia, Primary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751212 BXGD010351 Hyperalgesia, Secondary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751213 BXGD010352 Tactile Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0856825 BXGD011118 Acute GVH disease Immune System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1281914 BXGD012135 Corneal allograft rejection
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332225 BXGD012515 Aggressive Non-Hodgkin Lymphoma
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1842371 BXGD014513 DEAFNESS, AUTOSOMAL DOMINANT 41 (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1843156 BXGD014561 Progressive sensorineural hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3711374 BXGD019382 Nonsyndromic Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4529962 BXGD023178 Fatty Liver Disease
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0043088 Pyridoxal Phosphate 247.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein