Showing entry for ADP/ATP translocase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007774
Protein NameADP/ATP translocase 1
Uniport IdP12235
GeneSLC25A4
Gene Id291
DomainMito_carr
Pfam PF00153  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04217 Necroptosis
4. Cellular Processes 4.2 Cell growth and death hsa04218 Cellular senescence
6. Human Diseases 6.4 Neurodegenerative diseases hsa05012 Parkinson disease
6. Human Diseases 6.4 Neurodegenerative diseases hsa05016 Huntington disease
6. Human Diseases 6.9 Infectious diseases: Viral hsa05164 Influenza A
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015866 ADP transport
Biological Process GO:0008637 apoptotic mitochondrial changes
Biological Process GO:0006091 generation of precursor metabolites and energy
Biological Process GO:0000002 mitochondrial genome maintenance
Biological Process GO:0060546 negative regulation of necroptotic process
Biological Process GO:0050796 regulation of insulin secretion
Biological Process GO:0016032 viral process
molecular function GO:0015207 adenine transmembrane transporter activity
molecular function GO:0005347 ATP transmembrane transporter activity
cellular component GO:0032592 integral component of mitochondrial membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1268020 Mitochondrial protein import
R-HSA-1268020 Mitochondrial protein import
R-HSA-162906 HIV Infection
R-HSA-162909 Host Interactions of HIV factors
R-HSA-1643685 Disease
R-HSA-176033 Interactions of Vpr with host cellular proteins
R-HSA-180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
R-HSA-382551 Transport of small molecules
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-5663205 Infectious disease
R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
R-HSA-9609507 Protein localization
R-HSA-9609507 Protein localization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001125 BXGD000024 Acidosis, Lactic Nutritional and Metabolic Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003537 BXGD000208 Aphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0005956 BXGD000356 Bone Marrow Diseases Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007192 BXGD000450 Cardiomyopathy, Alcoholic Chemically-Induced Disorders; Cardiovascular Diseases
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010036 BXGD000642 Corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0014378 BXGD000912 Enterovirus Infections Infections
C0015469 BXGD000996 Facial paralysis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018021 BXGD001162 Goiter Endocrine System Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0022541 BXGD001550 Kearns-Sayre syndrome Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C0022638 BXGD001567 Ketosis Nutritional and Metabolic Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023380 BXGD001640 Lethargy Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028734 BXGD002080 Nocturia Pathological Conditions, Signs and Symptoms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037928 BXGD002713 Spinal Cord Diseases Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0041834 BXGD002935 Erythema Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0086439 BXGD003284 Hypokinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151564 BXGD003440 Cogwheel Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152020 BXGD003519 Gastroparesis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0162292 BXGD003930 External Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0162670 BXGD003970 Mitochondrial Myopathies Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0162671 BXGD003971 MELAS Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C0162672 BXGD003972 MERRF Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0162674 BXGD003973 Chronic progressive external ophthalmoplegia Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0231528 BXGD004496 Myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0231807 BXGD004524 Dyspnea on exertion Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234379 BXGD004662 Resting Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0238288 BXGD004905 Muscular Dystrophy, Facioscapulohumeral Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0239067 BXGD004961 Difficulty walking up stairs Pathological Conditions, Signs and Symptoms
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0342418 BXGD007478 Hypothalamic hamartomas Neoplasms; Nervous System Diseases
C0344424 BXGD007669 Ventricular Arrhythmia by ECG Finding
C0369183 BXGD007960 Erythrocyte Mean Corpuscular Hemoglobin Test
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0424551 BXGD008533 Impaired exercise tolerance
C0427063 BXGD008602 Shoulder girdle weakness
C0432072 BXGD008718 Dysmorphic features
C0476397 BXGD008991 Electroretinogram abnormal
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0558845 BXGD009459 Reflex, Ankle, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0577655 BXGD009536 Quadriceps weakness Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0746674 BXGD010147 Generalized muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0795692 BXGD010730 Hyperlactatemia Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0813217 BXGD010854 Expressionless face Nervous System Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0853897 BXGD010985 Diabetic Cardiomyopathies Endocrine System Diseases; Cardiovascular Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0949658 BXGD011582 Cardiomyopathy, Hypertrophic, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1263857 BXGD011900 Peripheral axonal neuropathy Nervous System Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1611743 BXGD013456 Familial (FPAH)
C1834846 BXGD013997 Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 1 Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C1836003 BXGD014069 Facial diplegia Infections; Nervous System Diseases; Stomatognathic Diseases
C1836440 BXGD014115 Increased serum lactate Nutritional and Metabolic Diseases
C1836460 BXGD014119 Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 2 Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases
C1837098 BXGD014198 Easy fatigability
C1839839 BXGD014416 MAJOR AFFECTIVE DISORDER 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C1843156 BXGD014561 Progressive sensorineural hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1848701 BXGD014967 Elevated hepatic transaminase
C1852197 BXGD015264 MAJOR AFFECTIVE DISORDER 1 Mental Disorders
C1854494 BXGD015409 Slow progression
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859317 BXGD015874 Cataract and cardiomyopathy Eye Diseases; Cardiovascular Diseases
C1883529 BXGD016597 Ventricular Arrhythmia, CTCAE 3.0
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1970943 BXGD016852 MAJOR AFFECTIVE DISORDER 4 Mental Disorders
C1970945 BXGD016853 MAJOR AFFECTIVE DISORDER 6 Mental Disorders
C1998028 BXGD016865 Photoreceptor degeneration Eye Diseases
C2676780 BXGD017346 Progeroid Syndrome, Congenital, Petty Type Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2700438 BXGD017469 MAJOR AFFECTIVE DISORDER 7 Mental Disorders
C2700439 BXGD017470 MAJOR AFFECTIVE DISORDER 8 Mental Disorders
C2700440 BXGD017471 MAJOR AFFECTIVE DISORDER 9 Mental Disorders
C2718001 BXGD017521 Protein Misfolding Disorders Nutritional and Metabolic Diseases
C2751582 BXGD017726 Mitochondrial respiratory chain defects
C3160712 BXGD018467 Palpitations, CTCAE
C3275417 BXGD018663 Ragged-red muscle fibers
C3277376 BXGD018713 Multiple mitochondrial DNA deletions
C3806467 BXGD019513 Respiratory insufficiency due to muscle weakness Respiratory Tract Diseases
C3809443 BXGD019589 MITOCHONDRIAL DNA DEPLETION SYNDROME 12B (CARDIOMYOPATHIC TYPE), AUTOSOMAL RECESSIVE
C3810365 BXGD019652 Central visual impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021724 BXGD020734 Cytochrome C oxidase-negative muscle fibers
C4021726 BXGD020735 EMG: myopathic abnormalities Musculoskeletal Diseases; Nervous System Diseases
C4021734 BXGD020742 Abnormality of mitochondrial metabolism
C4022792 BXGD020999 Reduced ejection fraction
C4023042 BXGD021081 Abnormality of the mitochondrion
C4024946 BXGD021493 Focal white matter lesions Pathological Conditions, Signs and Symptoms
C4025597 BXGD021685 Subsarcolemmal accumulations of abnormally shaped mitochondria
C4048268 BXGD021896 Cortical visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4310676 BXGD022621 MITOCHONDRIAL DNA DEPLETION SYNDROME 12A (CARDIOMYOPATHIC TYPE), AUTOSOMAL DOMINANT
C4321247 BXGD022745 Mitochondrial DNA Depletion Syndrome 12
C4552811 BXGD023526 Generalized Muscle Weakness, CTCAE
C4553764 BXGD023550 Ventricular Arrhythmia, CTCAE 5.0
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003330 Cardiolipin 1466.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein