Showing entry for Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012674
Protein NameProcollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Uniport IdQ02809
GenePLOD1
Gene Id5351
Domain2OG-FeII_Oxy
Pfam PF03171  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00310 Lysine degradation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008544 epidermis development
Biological Process GO:0017185 peptidyl-lysine hydroxylation
Biological Process GO:0001666 response to hypoxia
molecular function GO:0005506 iron ion binding
molecular function GO:0031418 L-ascorbic acid binding
molecular function GO:0008475 procollagen-lysine 5-dioxygenase activity
cellular component GO:1902494 catalytic complex
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0030867 rough endoplasmic reticulum membrane
Reactome
Pathway Id Pathway Name
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474290 Collagen formation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0002949 BXGD000157 Aneurysm, Dissecting Cardiovascular Diseases
C0003706 BXGD000215 Arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006277 BXGD000387 Bronchitis Infections; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009782 BXGD000631 Connective Tissue Diseases Skin and Connective Tissue Diseases
C0010036 BXGD000642 Corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0013720 BXGD000861 Ehlers-Danlos Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015944 BXGD001028 Fetal Membranes, Premature Rupture Female Urogenital Diseases and Pregnancy Complications
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017181 BXGD001103 Gastrointestinal Hemorrhage Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0019322 BXGD001317 Umbilical hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0026267 BXGD001896 Mitral Valve Prolapse Syndrome Cardiovascular Diseases
C0026654 BXGD001914 Moyamoya Disease Nervous System Diseases; Cardiovascular Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0032181 BXGD002332 Platelet Count measurement
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0035305 BXGD002529 Retinal Detachment Eye Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0040433 BXGD002865 Tooth Crowding Stomatognathic Diseases
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0149630 BXGD003334 Bicuspid aortic valve Cardiovascular Diseases
C0151544 BXGD003436 Gastrointestinal carcinoma Digestive System Diseases; Neoplasms
C0155760 BXGD003817 Rupture of artery
C0156273 BXGD003847 Bladder Diverticulum Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0221358 BXGD004450 Long narrow head
C0232466 BXGD004543 Feeding difficulties
C0235063 BXGD004718 Respiratory Depression Respiratory Tract Diseases
C0235659 BXGD004763 Reduced fetal movement Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0241074 BXGD005078 Hyperextensible skin
C0241240 BXGD005089 Tall stature
C0265341 BXGD005524 Rieger syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0266544 BXGD005691 Microcornea Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0268342 BXGD005904 Ehlers-Danlos syndrome type 6 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0271183 BXGD006169 Severe myopia Eye Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0340643 BXGD007357 Dissection of aorta Cardiovascular Diseases
C0342387 BXGD007472 LH - luteinizing hormone deficiency Nervous System Diseases; Endocrine System Diseases
C0345392 BXGD007732 Congenital kyphoscoliosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0423757 BXGD008504 Thin skin
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0426790 BXGD008577 Narrow thorax
C0428883 BXGD008639 Diastolic blood pressure
C0431659 BXGD008699 Hypoplasia of scrotum
C0431663 BXGD008700 Bilateral Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0542514 BXGD009277 Blue sclera Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0575158 BXGD009515 Kyphoscoliosis deformity of spine Musculoskeletal Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600033 BXGD009682 Acquired Kyphoscoliosis Musculoskeletal Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0694550 BXGD009852 Recurrent pneumonia Infections; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0749379 BXGD010214 Thoracolumbar scoliosis Musculoskeletal Diseases
C0795690 BXGD010728 Congenital omphalocele Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0854107 BXGD010999 Subcutaneous hemorrhage Skin and Connective Tissue Diseases
C1291314 BXGD012209 Deficiency of monooxygenase
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1836308 BXGD014107 Generalized joint laxity
C1836542 BXGD014129 Depressed nasal bridge
C1836599 BXGD014136 Macrocephaly at birth Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1836996 BXGD014183 Disproportionate tall stature
C1837397 BXGD014227 Severe global developmental delay
C1844592 BXGD014649 Soft skin
C1844597 BXGD014650 Molluscoid pseudotumors
C1844820 BXGD014681 Range of joint movement increased
C1845123 BXGD014714 Generalized neonatal hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854301 BXGD015391 Motor delay Mental Disorders
C1856714 BXGD015634 Palmoplantar cutis laxa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1857025 BXGD015666 Progressive congenital scoliosis Musculoskeletal Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1962966 BXGD016678 Retinopathy, CTCAE
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2267233 BXGD017017 Neonatal Hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2931384 BXGD018014 Moyamoya disease 1 Nervous System Diseases; Cardiovascular Diseases
C2936777 BXGD018133 Nevo syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3495488 BXGD018987 Axenfeld-Rieger syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3553764 BXGD019187 Joint hyperflexibility
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3697248 BXGD019355 Short lower third of face
C3887638 BXGD019906 Failure to thrive in infant Pathological Conditions, Signs and Symptoms
C4021735 BXGD020743 Abnormality of the hip bone
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4021786 BXGD020779 Atypical scarring of skin Pathological Conditions, Signs and Symptoms
C4023719 BXGD021251 Spontaneous rupture of the globe
C4082172 BXGD022086 Porencephalic cyst
C4551497 BXGD023321 Ehlers-Danlos syndrome kyphoscoliotic type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4707243 BXGD023712 Familial thoracic aortic aneurysm and aortic dissection
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000764 L-Ascorbic acid 176.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein