protein

Showing entry for Antigen peptide transporter 1

General Target Information
BXGT Id	BXGT012723
Protein Name	Antigen peptide transporter 1
Uniport Id	Q03518
Gene	TAP1
Gene Id	6890
Domain	ABC_membrane; ABC_tran
Pfam	PF00664 PF00005
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
3. Environmental Information Processing	3.1 Membrane transport	hsa02010	ABC transporters
4. Cellular Processes	4.1 Transport and catabolism	hsa04145	Phagosome
5. Organismal Systems	5.1 Immune system	hsa04612	Antigen processing and presentation
6. Human Diseases	6.9 Infectious diseases: Viral	hsa05163	Human cytomegalovirus infection
6. Human Diseases	6.9 Infectious diseases: Viral	hsa05168	Herpes simplex virus 1 infection
6. Human Diseases	6.9 Infectious diseases: Viral	hsa05169	Epstein-Barr virus infection
6. Human Diseases	6.9 Infectious diseases: Viral	hsa05170	Human immunodeficiency virus 1 infection
6. Human Diseases	6.3 Immune diseases	hsa05340	Primary immunodeficiency

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0002250	adaptive immune response
Biological Process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I
Biological Process	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
Biological Process	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
Biological Process	GO:0046967	cytosol to endoplasmic reticulum transport
Biological Process	GO:0006952	defense response
Biological Process	GO:0015833	peptide transport
Biological Process	GO:0015031	protein transport
Biological Process	GO:0055085	transmembrane transport
Biological Process	GO:1990668	vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
Biological Process	GO:0016032	viral process
molecular function	GO:0043531	ADP binding
molecular function	GO:0016887	ATPase activity
molecular function	GO:0015433	ATPase-coupled peptide antigen transmembrane transporter activity
molecular function	GO:0015440	ATPase-coupled peptide transmembrane transporter activity
molecular function	GO:0042626	ATPase-coupled transmembrane transporter activity
molecular function	GO:0005524	ATP binding
molecular function	GO:0023029	MHC class Ib protein binding
molecular function	GO:0042288	MHC class I protein binding
molecular function	GO:0042605	peptide antigen binding
molecular function	GO:1904680	peptide transmembrane transporter activity
molecular function	GO:0042803	protein homodimerization activity
molecular function	GO:0046978	TAP1 binding
molecular function	GO:0046979	TAP2 binding
cellular component	GO:0034451	centriolar satellite
cellular component	GO:0005783	endoplasmic reticulum
cellular component	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
cellular component	GO:0005789	endoplasmic reticulum membrane
cellular component	GO:0030176	integral component of endoplasmic reticulum membrane
cellular component	GO:0016021	integral component of membrane
cellular component	GO:0016020	membrane
cellular component	GO:0042824	MHC class I peptide loading complex
cellular component	GO:0030670	phagocytic vesicle membrane
cellular component	GO:0042825	TAP complex

Reactome

Pathway Id	Pathway Name
R-HSA-1236974	ER-Phagosome pathway
R-HSA-1236974	ER-Phagosome pathway
R-HSA-1236975	Antigen processing-Cross presentation
R-HSA-1236975	Antigen processing-Cross presentation
R-HSA-1280218	Adaptive Immune System
R-HSA-1280218	Adaptive Immune System
R-HSA-168256	Immune System
R-HSA-168256	Immune System
R-HSA-983169	Class I MHC mediated antigen processing & presentation
R-HSA-983169	Class I MHC mediated antigen processing & presentation
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0002170	BXGD000105	Alopecia	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002171	BXGD000106	Alopecia Areata	Skin and Connective Tissue Diseases
C0002390	BXGD000110	Extrinsic allergic alveolitis	Respiratory Tract Diseases; Immune System Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096	BXGD000252	Asthma	Respiratory Tract Diseases; Immune System Diseases
C0004364	BXGD000270	Autoimmune Diseases	Immune System Diseases
C0004943	BXGD000297	Behcet Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006267	BXGD000383	Bronchiectasis	Respiratory Tract Diseases
C0006271	BXGD000384	Bronchiolitis	Infections; Respiratory Tract Diseases
C0006413	BXGD000397	Burkitt Lymphoma	Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007097	BXGD000424	Carcinoma	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0007134	BXGD000443	Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007570	BXGD000467	Celiac Disease	Digestive System Diseases; Nutritional and Metabolic Diseases
C0007847	BXGD000492	Malignant tumor of cervix	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009324	BXGD000597	Ulcerative Colitis	Digestive System Diseases
C0009375	BXGD000602	Colonic Neoplasms	Digestive System Diseases; Neoplasms
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0010232	BXGD000655	Cowpox	Infections
C0010278	BXGD000660	Craniosynostosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010346	BXGD000664	Crohn Disease	Digestive System Diseases
C0010414	BXGD000669	Infection by Cryptococcus neoformans	Infections
C0010674	BXGD000683	Cystic Fibrosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011195	BXGD000702	Dejerine-Sottas Disease (disorder)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0011311	BXGD000714	Dengue Fever	Infections
C0011603	BXGD000734	Dermatitis	Skin and Connective Tissue Diseases
C0011615	BXGD000738	Dermatitis, Atopic	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013537	BXGD000853	Eclampsia	Female Urogenital Diseases and Pregnancy Complications
C0013581	BXGD000855	Ectopia Lentis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0013595	BXGD000858	Eczema	Skin and Connective Tissue Diseases
C0013990	BXGD000874	Pathological accumulation of air in tissues	Pathological Conditions, Signs and Symptoms
C0014544	BXGD000926	Epilepsy	Nervous System Diseases
C0014548	BXGD000928	Epilepsy, Generalized	Nervous System Diseases
C0014859	BXGD000961	Esophageal Neoplasms	Digestive System Diseases; Neoplasms
C0017601	BXGD001125	Glaucoma	Eye Diseases
C0017612	BXGD001129	Glaucoma, Open-Angle	Eye Diseases
C0017636	BXGD001131	Glioblastoma	Neoplasms
C0017638	BXGD001132	Glioma	Neoplasms
C0017665	BXGD001141	Membranous glomerulonephritis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018213	BXGD001187	Graves Disease	Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0019100	BXGD001283	Severe Dengue	Infections
C0019163	BXGD001295	Hepatitis B	Digestive System Diseases; Infections
C0019196	BXGD001301	Hepatitis C	Digestive System Diseases; Infections
C0019348	BXGD001325	Herpes Simplex Infections	Infections; Skin and Connective Tissue Diseases
C0019829	BXGD001350	Hodgkin Disease	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0020615	BXGD001445	Hypoglycemia	Nutritional and Metabolic Diseases
C0021053	BXGD001476	Immune System Diseases	Immune System Diseases
C0021400	BXGD001504	Influenza	Infections; Respiratory Tract Diseases
C0023343	BXGD001635	Leprosy	Infections
C0023351	BXGD001637	Tuberculoid leprosy	Infections
C0023418	BXGD001642	leukemia	Neoplasms
C0023890	BXGD001713	Liver Cirrhosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895	BXGD001717	Liver diseases	Digestive System Diseases
C0024141	BXGD001740	Lupus Erythematosus, Systemic	Skin and Connective Tissue Diseases; Immune System Diseases
C0024530	BXGD001783	Malaria	Infections
C0025202	BXGD001832	melanoma	Neoplasms
C0026769	BXGD001930	Multiple Sclerosis	Immune System Diseases; Nervous System Diseases
C0026896	BXGD001946	Myasthenia Gravis	Neoplasms; Immune System Diseases; Nervous System Diseases
C0027404	BXGD001984	Narcolepsy	Nervous System Diseases; Mental Disorders
C0027430	BXGD001988	Nasal Polyps	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027819	BXGD002043	Neuroblastoma	Neoplasms
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0030809	BXGD002258	Pemphigus Vulgaris	Skin and Connective Tissue Diseases; Immune System Diseases
C0032914	BXGD002379	Pre-Eclampsia	Female Urogenital Diseases and Pregnancy Complications
C0033578	BXGD002408	Prostatic Neoplasms	Neoplasms; Male Urogenital Diseases
C0033860	BXGD002438	Psoriasis	Skin and Connective Tissue Diseases
C0035012	BXGD002500	Reiter Syndrome	Infections; Musculoskeletal Diseases
C0035235	BXGD002519	Respiratory Syncytial Virus Infections	Infections
C0036202	BXGD002581	Sarcoidosis	Hemic and Lymphatic Diseases
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0036421	BXGD002613	Systemic Scleroderma	Skin and Connective Tissue Diseases
C0036749	BXGD002633	Serositis	Pathological Conditions, Signs and Symptoms
C0036974	BXGD002648	Shock	Pathological Conditions, Signs and Symptoms
C0037284	BXGD002679	Skin lesion	Skin and Connective Tissue Diseases
C0037299	BXGD002685	Skin Ulcer	Skin and Connective Tissue Diseases
C0038013	BXGD002725	Ankylosing spondylitis	Musculoskeletal Diseases
C0039101	BXGD002790	synovial sarcoma	Neoplasms
C0041296	BXGD002903	Tuberculosis	Infections
C0041327	BXGD002916	Tuberculosis, Pulmonary	Infections; Respiratory Tract Diseases
C0042769	BXGD002999	Virus Diseases	Infections
C0042900	BXGD003012	Vitiligo	Skin and Connective Tissue Diseases
C0043124	BXGD003031	West Nile Fever	Infections; Nervous System Diseases
C0085435	BXGD003176	Arthritis, Reactive	Infections; Musculoskeletal Diseases
C0149516	BXGD003324	Chronic sinusitis	Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0149678	BXGD003346	Epstein-Barr Virus Infections	Infections
C0149745	BXGD003356	Oral Ulcer	Stomatognathic Diseases
C0149925	BXGD003387	Small cell carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0151517	BXGD003431	Complete atrioventricular block	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151744	BXGD003469	Myocardial Ischemia	Cardiovascular Diseases
C0152018	BXGD003518	Esophageal carcinoma	Digestive System Diseases; Neoplasms
C0152069	BXGD003527	Echinococcus multilocularis infection	Infections
C0155877	BXGD003830	Allergic asthma	Respiratory Tract Diseases; Immune System Diseases
C0162429	BXGD003942	Malnutrition	Nutritional and Metabolic Diseases
C0206138	BXGD004158	CREST Syndrome	Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0206708	BXGD004256	Cervical Intraepithelial Neoplasia	Neoplasms
C0221376	BXGD004455	Hydrosalpinx (disease)	Female Urogenital Diseases and Pregnancy Complications; Infections
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0242583	BXGD005178	Bare Lymphocyte Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0263361	BXGD005292	Psoriasis vulgaris	Skin and Connective Tissue Diseases
C0270853	BXGD006119	Juvenile Myoclonic Epilepsy	Nervous System Diseases
C0271441	BXGD006203	Chronic otitis media	Otorhinolaryngologic Diseases
C0272199	BXGD006322	Familial Hemophagocytic Lymphocytosis	Hemic and Lymphatic Diseases
C0275518	BXGD006375	Acute infectious disease	Pathological Conditions, Signs and Symptoms; Infections
C0275524	BXGD006376	Coinfection	Infections
C0278660	BXGD006555	Adult Synovial Sarcoma	Neoplasms
C0278701	BXGD006566	Gastric Adenocarcinoma	Digestive System Diseases; Neoplasms
C0278764	BXGD006581	Adult Burkitt Lymphoma	Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278879	BXGD006610	Childhood Burkitt Lymphoma	Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278883	BXGD006614	Metastatic melanoma	Neoplasms
C0279626	BXGD006657	Squamous cell carcinoma of esophagus	Digestive System Diseases; Neoplasms
C0279671	BXGD006677	Cervical Squamous Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0279702	BXGD006685	Conventional (Clear Cell) Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279982	BXGD006702	Childhood Synovial Sarcoma	Neoplasms
C0302592	BXGD006851	Cervix carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0339573	BXGD007271	Glaucoma, Primary Open Angle	Eye Diseases
C0339985	BXGD007296	Idiopathic bronchiectasis	Respiratory Tract Diseases
C0343641	BXGD007636	Human papilloma virus infection	Infections
C0375023	BXGD007970	Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0376545	BXGD008002	Hematologic Neoplasms	Neoplasms; Hemic and Lymphatic Diseases
C0476089	BXGD008977	Endometrial Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0524851	BXGD009246	Neurodegenerative Disorders	Nervous System Diseases
C0524909	BXGD009247	Hepatitis B, Chronic	Digestive System Diseases; Infections
C0524910	BXGD009248	Hepatitis C, Chronic	Digestive System Diseases; Infections
C0546837	BXGD009343	Malignant neoplasm of esophagus	Digestive System Diseases; Neoplasms
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0700095	BXGD009875	Central neuroblastoma	Neoplasms; Nervous System Diseases
C0741796	BXGD010041	Recurrent bronchitis	Infections; Respiratory Tract Diseases
C0851140	BXGD010916	Carcinoma in situ of uterine cervix	Neoplasms
C0919267	BXGD011426	ovarian neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948201	BXGD011515	Alloimmunisation
C1140680	BXGD011718	Malignant neoplasm of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168198	BXGD011782	Recurrent respiratory papillomatosis	Infections; Respiratory Tract Diseases
C1168401	BXGD011792	Squamous cell carcinoma of the head and neck	Neoplasms
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1328840	BXGD012474	Autoimmune Lymphoproliferative Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C1332922	BXGD012556	Cervical Squamous Intraepithelial Neoplasia	Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1335302	BXGD012775	Pancreatic Ductal Adenocarcinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1458155	BXGD013136	Mammary Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C1527336	BXGD013271	Sjogren's Syndrome	Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1621958	BXGD013468	Glioblastoma Multiforme	Neoplasms
C1847835	BXGD014892	VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	Skin and Connective Tissue Diseases
C1848296	BXGD014918	DOSAGE-SENSITIVE SEX REVERSAL	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1858266	BXGD015780	Bare Lymphocyte Syndrome, Type I	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C1960398	BXGD016658	HER2-positive carcinoma of breast	Neoplasms; Skin and Connective Tissue Diseases
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2363741	BXGD017100	HIV-1 infection
C2607914	BXGD017148	Allergic rhinitis (disorder)	Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2747816	BXGD017577	Complicated malaria	Infections
C2931418	BXGD018019	Bare lymphocyte syndrome 2	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C2931822	BXGD018068	Nasopharyngeal carcinoma	Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939419	BXGD018178	Secondary Neoplasm	Pathological Conditions, Signs and Symptoms; Neoplasms
C2986665	BXGD018237	Early-Stage Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C3266262	BXGD018600	Multiple Chronic Conditions	Pathological Conditions, Signs and Symptoms
C3495559	BXGD018994	Juvenile arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3714514	BXGD019409	Infection	Infections
C3714757	BXGD019430	Juvenile rheumatoid arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3826758	BXGD019733	AIDS (Disease)
C3853540	BXGD019820	Aspirin exacerbated respiratory disease	Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases; Immune System Diseases; Chemically-Induced Disorders; Otorhinolaryngologic Diseases
C3854222	BXGD019826	Human immunodeficiency virus (HIV) II infection category B1
C4048328	BXGD021903	cervical cancer	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4048329	BXGD021904	Immunosuppression
C4086165	BXGD022126	Childhood Neuroblastoma	Neoplasms
C4303092	BXGD022550	Cystic echinococcosis	Pathological Conditions, Signs and Symptoms; Neoplasms; Infections
C4721610	BXGD023760	Carcinoma, Ovarian Epithelial	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum
C4722419	BXGD023802	Extrapulmonary Small Cell Carcinoma	Neoplasms

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0002588	Magnesium		24.31

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}