protein

Showing entry for Interferon gamma receptor 1

General Target Information
BXGT Id	BXGT023924
Protein Name	Interferon gamma receptor 1
Uniport Id	P15260
Gene	IFNGR1
Gene Id	3459
Domain	IFNGR1; Tissue_fac
Pfam	PF07140 PF01108
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
3. Environmental Information Processing	3.3 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction
3. Environmental Information Processing	3.2 Signal transduction	hsa04066	HIF-1 signaling pathway
4. Cellular Processes	4.2 Cell growth and death	hsa04217	Necroptosis
5. Organismal Systems	5.8 Development	hsa04380	Osteoclast differentiation
3. Environmental Information Processing	3.2 Signal transduction	hsa04630	Jak-STAT signaling pathway
5. Organismal Systems	5.1 Immune system	hsa04650	Natural killer cell mediated cytotoxicity
5. Organismal Systems	5.1 Immune system	hsa04658	Th1 and Th2 cell differentiation
5. Organismal Systems	5.1 Immune system	hsa04659	Th17 cell differentiation
6. Human Diseases	6.8 Infectious diseases: Bacterial	hsa05132	Salmonella infection
6. Human Diseases	6.10 Infectious diseases: Parasitic	hsa05140	Leishmaniasis
6. Human Diseases	6.10 Infectious diseases: Parasitic	hsa05142	Chagas disease (American trypanosomiasis)
6. Human Diseases	6.10 Infectious diseases: Parasitic	hsa05145	Toxoplasmosis
6. Human Diseases	6.8 Infectious diseases: Bacterial	hsa05152	Tuberculosis
6. Human Diseases	6.9 Infectious diseases: Viral	hsa05164	Influenza A
6. Human Diseases	6.9 Infectious diseases: Viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection
6. Human Diseases	6.9 Infectious diseases: Viral	hsa05168	Herpes simplex virus 1 infection
6. Human Diseases	6.1 Cancers: Overview	hsa05200	Pathways in cancer
6. Human Diseases	6.1 Cancers: Overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer
6. Human Diseases	6.3 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0048143	astrocyte activation
Biological Process	GO:0019221	cytokine-mediated signaling pathway
Biological Process	GO:0060333	interferon-gamma-mediated signaling pathway
Biological Process	GO:0001774	microglial cell activation
Biological Process	GO:1900222	negative regulation of amyloid-beta clearance
Biological Process	GO:1902004	positive regulation of amyloid-beta formation
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:1904469	positive regulation of tumor necrosis factor secretion
Biological Process	GO:0060334	regulation of interferon-gamma-mediated signaling pathway
Biological Process	GO:0009615	response to virus
Biological Process	GO:0007165	signal transduction
molecular function	GO:0019955	cytokine binding
molecular function	GO:0004896	cytokine receptor activity
molecular function	GO:0004906	interferon-gamma receptor activity
cellular component	GO:0016021	integral component of membrane
cellular component	GO:0005887	integral component of plasma membrane
cellular component	GO:0005886	plasma membrane

Reactome

Pathway Id	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system
R-HSA-1280215	Cytokine Signaling in Immune system
R-HSA-1643685	Disease
R-HSA-168256	Immune System
R-HSA-168256	Immune System
R-HSA-5663205	Infectious disease
R-HSA-877300	Interferon gamma signaling
R-HSA-877300	Interferon gamma signaling
R-HSA-877312	Regulation of IFNG signaling
R-HSA-877312	Regulation of IFNG signaling
R-HSA-913531	Interferon Signaling
R-HSA-913531	Interferon Signaling
R-HSA-9679191	Potential therapeutics for SARS
R-HSA-9679506	SARS-CoV Infections

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001418	BXGD000050	Adenocarcinoma	Neoplasms
C0001768	BXGD000075	Agammaglobulinemia	Immune System Diseases; Hemic and Lymphatic Diseases
C0002736	BXGD000127	Amyotrophic Lateral Sclerosis	Nutritional and Metabolic Diseases; Nervous System Diseases
C0002871	BXGD000132	Anemia	Hemic and Lymphatic Diseases
C0003123	BXGD000178	Anorexia	Pathological Conditions, Signs and Symptoms
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004623	BXGD000282	Bacterial Infections	Infections
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007113	BXGD000430	Rectal Carcinoma	Digestive System Diseases; Neoplasms
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0009319	BXGD000596	Colitis	Digestive System Diseases
C0009324	BXGD000597	Ulcerative Colitis	Digestive System Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0009763	BXGD000628	Conjunctivitis	Eye Diseases
C0010346	BXGD000664	Crohn Disease	Digestive System Diseases
C0010674	BXGD000683	Cystic Fibrosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011615	BXGD000738	Dermatitis, Atopic	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011991	BXGD000766	Diarrhea	Pathological Conditions, Signs and Symptoms
C0013537	BXGD000853	Eclampsia	Female Urogenital Diseases and Pregnancy Complications
C0013595	BXGD000858	Eczema	Skin and Connective Tissue Diseases
C0014175	BXGD000904	Endometriosis	Female Urogenital Diseases and Pregnancy Complications
C0014457	BXGD000915	Eosinophilia	Hemic and Lymphatic Diseases
C0014859	BXGD000961	Esophageal Neoplasms	Digestive System Diseases; Neoplasms
C0015967	BXGD001030	Fever	Pathological Conditions, Signs and Symptoms
C0016059	BXGD001043	Fibrosis	Pathological Conditions, Signs and Symptoms
C0017154	BXGD001097	Gastritis, Atrophic	Digestive System Diseases
C0019163	BXGD001295	Hepatitis B	Digestive System Diseases; Infections
C0019196	BXGD001301	Hepatitis C	Digestive System Diseases; Infections
C0019214	BXGD001307	Hepatosplenomegaly	Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Hemic and Lymphatic Diseases
C0019348	BXGD001325	Herpes Simplex Infections	Infections; Skin and Connective Tissue Diseases
C0019618	BXGD001339	Histiocytosis	Hemic and Lymphatic Diseases
C0019621	BXGD001340	Histiocytosis, Langerhans-Cell	Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0020455	BXGD001391	Hypergammaglobulinemia	Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020459	BXGD001394	Hyperinsulinism	Nutritional and Metabolic Diseases
C0021051	BXGD001475	Immunologic Deficiency Syndromes	Immune System Diseases
C0021390	BXGD001503	Inflammatory Bowel Diseases	Digestive System Diseases
C0021400	BXGD001504	Influenza	Infections; Respiratory Tract Diseases
C0023290	BXGD001631	Leishmaniasis, Visceral	Infections
C0023348	BXGD001636	Leprosy, Lepromatous	Infections
C0023434	BXGD001643	Chronic Lymphocytic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023518	BXGD001677	Leukocytosis	Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0023893	BXGD001716	Liver Cirrhosis, Experimental	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024115	BXGD001732	Lung diseases	Respiratory Tract Diseases
C0024141	BXGD001740	Lupus Erythematosus, Systemic	Skin and Connective Tissue Diseases; Immune System Diseases
C0024205	BXGD001744	Lymphadenitis	Hemic and Lymphatic Diseases
C0024266	BXGD001754	Lymphocytic Choriomeningitis	Infections; Nervous System Diseases
C0024291	BXGD001757	Lymphohistiocytosis, Hemophagocytic	Hemic and Lymphatic Diseases
C0024530	BXGD001783	Malaria	Infections
C0024534	BXGD001784	Malaria, Cerebral	Infections; Nervous System Diseases
C0024535	BXGD001785	Malaria, Falciparum	Infections
C0026769	BXGD001930	Multiple Sclerosis	Immune System Diseases; Nervous System Diseases
C0026896	BXGD001946	Myasthenia Gravis	Neoplasms; Immune System Diseases; Nervous System Diseases
C0026918	BXGD001948	Mycobacterium Infections	Infections
C0026919	BXGD001949	Mycobacterium Infections, Nontuberculous	Infections
C0027059	BXGD001965	Myocarditis	Cardiovascular Diseases
C0027651	BXGD002009	Neoplasms	Neoplasms
C0028081	BXGD002070	Night sweats
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029443	BXGD002152	Osteomyelitis	Infections; Musculoskeletal Diseases
C0029456	BXGD002157	Osteoporosis	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030499	BXGD002232	Parasitic Diseases	Infections
C0031099	BXGD002282	Periodontitis	Stomatognathic Diseases
C0032285	BXGD002344	Pneumonia	Infections; Respiratory Tract Diseases
C0032749	BXGD002369	Post-kala-azar dermal leishmaniasis	Infections; Skin and Connective Tissue Diseases
C0035455	BXGD002554	Rhinitis	Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0038002	BXGD002723	Splenomegaly	Pathological Conditions, Signs and Symptoms
C0039483	BXGD002813	Giant Cell Arteritis	Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0041296	BXGD002903	Tuberculosis	Infections
C0041327	BXGD002916	Tuberculosis, Pulmonary	Infections; Respiratory Tract Diseases
C0042769	BXGD002999	Virus Diseases	Infections
C0078911	BXGD003053	AIDS-Associated Nephropathy	Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases; Immune System Diseases
C0079487	BXGD003079	Helicobacter Infections	Infections
C0079731	BXGD003087	B-Cell Lymphomas	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085695	BXGD003243	Chronic gastritis	Digestive System Diseases
C0086543	BXGD003294	Cataract	Eye Diseases
C0149745	BXGD003356	Oral Ulcer	Stomatognathic Diseases
C0151379	BXGD003416	Rheumatoid factor positive (finding)
C0151517	BXGD003431	Complete atrioventricular block	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151632	BXGD003450	ESR raised
C0151744	BXGD003469	Myocardial Ischemia	Cardiovascular Diseases
C0152018	BXGD003518	Esophageal carcinoma	Digestive System Diseases; Neoplasms
C0152491	BXGD003601	Salmonella osteomyelitis	Infections; Musculoskeletal Diseases
C0152545	BXGD003605	Primary tuberculosis	Infections
C0152915	BXGD003607	Acute miliary tuberculosis	Infections
C0155877	BXGD003830	Allergic asthma	Respiratory Tract Diseases; Immune System Diseases
C0162359	BXGD003939	Christ-Siemens-Touraine syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0162628	BXGD003963	Skin Diseases, Viral	Infections; Skin and Connective Tissue Diseases
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0206064	BXGD004150	Microvascular Angina	Cardiovascular Diseases
C0235896	BXGD004785	Pulmonary Infiltrate	Respiratory Tract Diseases
C0239981	BXGD005011	Hypoalbuminemia	Hemic and Lymphatic Diseases
C0269102	BXGD006053	Endometrioma	Female Urogenital Diseases and Pregnancy Complications
C0271174	BXGD006167	Atopic cataract	Eye Diseases
C0276289	BXGD006418	Zika Virus Infection	Infections
C0333160	BXGD006927	Air cyst	Pathological Conditions, Signs and Symptoms; Neoplasms
C0333307	BXGD006946	Superficial ulcer	Pathological Conditions, Signs and Symptoms
C0374997	BXGD007967	Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0398686	BXGD008215	Primary immune deficiency disorder	Immune System Diseases
C0476486	BXGD008996	Generalized enlarged lymph nodes	Hemic and Lymphatic Diseases
C0497156	BXGD009053	Lymphadenopathy	Hemic and Lymphatic Diseases
C0521707	BXGD009166	Bilateral cataracts (disorder)	Eye Diseases
C0524909	BXGD009247	Hepatitis B, Chronic	Digestive System Diseases; Infections
C0524910	BXGD009248	Hepatitis C, Chronic	Digestive System Diseases; Infections
C0546837	BXGD009343	Malignant neoplasm of esophagus	Digestive System Diseases; Neoplasms
C0677932	BXGD009736	Progressive Neoplastic Disease
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0679362	BXGD009767	Tuberculosis, extrapulmonary	Infections
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0747256	BXGD010168	Parasitic infection	Pathological Conditions, Signs and Symptoms; Infections
C0747845	BXGD010184	early pregnancy
C0836924	BXGD010864	Thrombocytosis	Hemic and Lymphatic Diseases
C0850666	BXGD010901	Infection caused by Helicobacter pylori	Infections
C0860040	BXGD011213	BCG infection
C0876973	BXGD011322	Infectious Lung Disorder	Infections; Respiratory Tract Diseases
C0919747	BXGD011439	Cytokine storm
C0936250	BXGD011481	Eczema Herpeticum	Infections; Skin and Connective Tissue Diseases
C0940937	BXGD011490	precancerous lesions
C1112429	BXGD011666	Interferon gamma receptor deficiency
C1262477	BXGD011882	Weight decreased	Pathological Conditions, Signs and Symptoms
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306759	BXGD012374	Eosinophilic disorder	Hemic and Lymphatic Diseases
C1608955	BXGD013437	Mycobacterium abscessus Infection	Infections
C1706004	BXGD013569	Anhydrotic Ectodermal Dysplasias	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1827849	BXGD013780	IgE-mediated allergic asthma	Immune System Diseases
C1834752	BXGD013995	MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding)
C1856920	BXGD015657	Hypoplasia of the femoral head
C1861303	BXGD016026	SYNOVITIS, GRANULOMATOUS, WITH UVEITIS AND CRANIAL NEUROPATHIES (disorder)	Eye Diseases; Musculoskeletal Diseases
C2363741	BXGD017100	HIV-1 infection
C2721713	BXGD017545	Disseminated BCG
C2747816	BXGD017577	Complicated malaria	Infections
C2930924	BXGD017917	Interferon gamma, receptor 1, deficiency	Infections
C3266863	BXGD018605	Atypical Mycobacteriosis, Familial	Infections
C3539781	BXGD019086	Progressive cGVHD
C3714514	BXGD019409	Infection	Infections
C3826068	BXGD019711	Leprosy in children
C3826128	BXGD019713	Infection in children
C3830467	BXGD019752	Disseminated Bacillus Calmette-Guerin infection	Infections
C3887641	BXGD019909	Recurrent hepatitis	Digestive System Diseases
C3899655	BXGD020091	Childhood Langerhans Cell Histiocytosis	Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C3900100	BXGD020108	Adult Langerhans Cell Histiocytosis	Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C4011949	BXGD020117	IMMUNODEFICIENCY 27A
C4013949	BXGD020135	IMMUNODEFICIENCY 30
C4014863	BXGD020169	IMMUNODEFICIENCY 27B
C4020869	BXGD020489	Abnormality of abdomen morphology	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4023438	BXGD021185	Recurrent mycobacterial infections
C4288927	BXGD022489	IFN-gamma Receptor 1 Deficiency	Immune System Diseases
C4476563	BXGD022830	Enlarged mesenteric lymph node
C4476771	BXGD022865	Abnormal bronchus physiology
C4755296	BXGD024091	Susceptibility to viral and mycobacterial infection

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0018397	beta-1,4-mannan		180.06

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}