Showing entry for HLA class II histocompatibility antigen, DP alpha 1 chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022764
Protein NameHLA class II histocompatibility antigen, DP alpha 1 chain
Uniport IdP20036
GeneHLA-DPA1
Gene Id3113
DomainC1-set; MHC_II_alpha
Pfam PF07654   PF00993  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04514 Cell adhesion molecules (CAMs)
5. Organismal Systems 5.1 Immune system hsa04612 Antigen processing and presentation
5. Organismal Systems 5.1 Immune system hsa04640 Hematopoietic cell lineage
5. Organismal Systems 5.1 Immune system hsa04658 Th1 and Th2 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04659 Th17 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04672 Intestinal immune network for IgA production
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04940 Type I diabetes mellitus
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05140 Leishmaniasis
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05145 Toxoplasmosis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05152 Tuberculosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05164 Influenza A
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
6. Human Diseases 6.3 Immune diseases hsa05310 Asthma
6. Human Diseases 6.3 Immune diseases hsa05320 Autoimmune thyroid disease
6. Human Diseases 6.3 Immune diseases hsa05321 Inflammatory bowel disease (IBD)
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
6. Human Diseases 6.3 Immune diseases hsa05323 Rheumatoid arthritis
6. Human Diseases 6.3 Immune diseases hsa05330 Allograft rejection
6. Human Diseases 6.3 Immune diseases hsa05332 Graft-versus-host disease
6. Human Diseases 6.6 Cardiovascular diseases hsa05416 Viral myocarditis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0071346 cellular response to interferon-gamma
Biological Process GO:0006955 immune response
Biological Process GO:0060333 interferon-gamma-mediated signaling pathway
Biological Process GO:0032729 positive regulation of interferon-gamma production
Biological Process GO:0050870 positive regulation of T cell activation
Biological Process GO:0042102 positive regulation of T cell proliferation
Biological Process GO:0050852 T cell receptor signaling pathway
molecular function GO:0032395 MHC class II receptor activity
molecular function GO:0042605 peptide antigen binding
cellular component GO:0009986 cell surface
cellular component GO:0030669 clathrin-coated endocytic vesicle membrane
cellular component GO:0030666 endocytic vesicle membrane
cellular component GO:0010008 endosome membrane
cellular component GO:0012507 ER to Golgi transport vesicle membrane
cellular component GO:0000139 Golgi membrane
cellular component GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005765 lysosomal membrane
cellular component GO:0042613 MHC class II protein complex
cellular component GO:0005886 plasma membrane
cellular component GO:0032588 trans-Golgi network membrane
cellular component GO:0030658 transport vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling
R-HSA-913531 Interferon Signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0002893 BXGD000150 Refractory anemias Hemic and Lymphatic Diseases
C0002962 BXGD000160 Angina Pectoris Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004368 BXGD000271 Autoimmune state
C0007286 BXGD000459 Carpal Tunnel Syndrome Nervous System Diseases; Wounds and Injuries
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008031 BXGD000511 Chest Pain Pathological Conditions, Signs and Symptoms
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011303 BXGD000712 Demyelinating Diseases Nervous System Diseases
C0011633 BXGD000742 Dermatomyositis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0011848 BXGD000750 Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013295 BXGD000812 Duodenal Ulcer Digestive System Diseases
C0014059 BXGD000881 Encephalomyelitis, Acute Disseminated Immune System Diseases; Nervous System Diseases
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0015300 BXGD000973 Exophthalmos Eye Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017086 BXGD001091 Gangrene Pathological Conditions, Signs and Symptoms
C0017152 BXGD001096 Gastritis Digestive System Diseases
C0017181 BXGD001103 Gastrointestinal Hemorrhage Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0017605 BXGD001126 Angle Closure Glaucoma Eye Diseases
C0017606 BXGD001127 Primary angle-closure glaucoma Eye Diseases
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018991 BXGD001264 Hemiplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0019079 BXGD001278 Hemoptysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021843 BXGD001520 Intestinal Obstruction Digestive System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026896 BXGD001946 Myasthenia Gravis Neoplasms; Immune System Diseases; Nervous System Diseases
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027873 BXGD002054 Neuromyelitis Optica Eye Diseases; Immune System Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0031046 BXGD002275 Pericarditis Cardiovascular Diseases
C0032231 BXGD002339 Pleurisy Infections; Respiratory Tract Diseases
C0033581 BXGD002410 prostatitis Male Urogenital Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0034150 BXGD002466 Purpura Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0036323 BXGD002595 Schistosomiasis Infections
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037199 BXGD002671 Sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0037299 BXGD002685 Skin Ulcer Skin and Connective Tissue Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0038358 BXGD002748 Gastric ulcer Digestive System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039263 BXGD002805 Takayasu Arteritis Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0042384 BXGD002979 Vasculitis Cardiovascular Diseases
C0042487 BXGD002986 Venous Thrombosis Cardiovascular Diseases
C0149745 BXGD003356 Oral Ulcer Stomatognathic Diseases
C0151205 BXGD003406 Periorbital edema Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C0151311 BXGD003412 Cranial nerve palsies Nervous System Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151632 BXGD003450 ESR raised
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0155880 BXGD003831 Intrinsic asthma Respiratory Tract Diseases; Immune System Diseases
C0157917 BXGD003872 Pauciarticular juvenile rheumatoid arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0162823 BXGD003986 Dermatitis, Irritant Skin and Connective Tissue Diseases
C0221052 BXGD004380 Chronic berylliosis Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases; Occupational Diseases; Wounds and Injuries
C0231528 BXGD004496 Myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0235896 BXGD004785 Pulmonary Infiltrate Respiratory Tract Diseases
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0268731 BXGD006029 Renal glomerular disease Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0271441 BXGD006203 Chronic otitis media Otorhinolaryngologic Diseases
C0276926 BXGD006456 Schistosoma hematobium infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0332563 BXGD006894 Papule Pathological Conditions, Signs and Symptoms
C0376544 BXGD008001 Hematopoietic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0398367 BXGD008187 Histiocytic Necrotizing Lymphadenitis Hemic and Lymphatic Diseases
C0521173 BXGD009132 Granulomatosis
C0521618 BXGD009148 Stenosis of ureter Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0524909 BXGD009247 Hepatitis B, Chronic Digestive System Diseases; Infections
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0543699 BXGD009293 ASA intolerant asthma Respiratory Tract Diseases; Immune System Diseases
C0543982 BXGD009304 Glaucoma, primary Eye Diseases
C0836924 BXGD010864 Thrombocytosis Hemic and Lymphatic Diseases
C0856825 BXGD011118 Acute GVH disease Immune System Diseases
C0917798 BXGD011409 Cerebral Ischemia Nervous System Diseases; Cardiovascular Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1519353 BXGD013236 Skin Papule Skin and Connective Tissue Diseases
C1527304 BXGD013266 Allergic Reaction Immune System Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1701938 BXGD013524 Associated Pulmonary Arterial Hypertension Respiratory Tract Diseases
C1962966 BXGD016678 Retinopathy, CTCAE
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3277226 BXGD018711 Restrictive ventilatory defect
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3495801 BXGD019004 Granulomatosis with polyangiitis Respiratory Tract Diseases; Immune System Diseases; Cardiovascular Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3805919 BXGD019494 Recurrent intrapulmonary hemorrhage
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C3887590 BXGD019900 Stricture of ureter Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4020969 BXGD020517 Inflammatory abnormality of the eye
C4023452 BXGD021191 Elevated C-reactive protein level
C4025819 BXGD021808 Abnormality of the hypothalamus-pituitary axis
C4025887 BXGD021847 Abnormal oral cavity morphology
C4075603 BXGD022070 Occult chronic type B viral hepatitis Digestive System Diseases; Infections
C4521256 BXGD023058 Glomerulopathy Assessment
C4553313 BXGD023540 Periorbital Edema, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein